{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:20:41Z","timestamp":1791991241499,"version":"4.4.0"},"reference-count":18,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100016380","name":"Copenhagen University Hospital Herlev and Gentofte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Insulinomas, although rare, are among the most common functional pancreatic neuroendocrine neoplasms (pNENs), causing debilitating and recurrent hypoglycemic episodes and severely affecting quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) as a novel and minimally invasive treatment for insulinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>We retrospectively identified patients at a single tertiary care center between 2022 and 2025 with a suspicion of insulinomas (based on a positive fasting test and imaging) who underwent EUS-RFA. Lesions considered for RFA were biopsy-proven pNENs with a Ki-67 index &amp;lt;10%, and &amp;lt;25\u2005mm in size. All patients were hospitalized for 24\u2005hours and EUS-RFA was conducted under general anesthesia using a dedicated EUS-RFA needle and under direct ultrasound guidance. Mean follow-up duration was 15.5 months. The primary outcome measure was clinical success (symptom improvement with a documented increase in blood glucose) and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 17 patients were identified and included. The mean age was 60.1 years and 53% were male. Normoglycemia was achieved after a single EUS-RFA session in 11 patients (64.7%), while 6 patients (35.3%) required a second EUS-RFA. The overall clinical success rate was 100% (n = 17\/17; 95% CI: 80.4%-100.0%). A total of 4 adverse events were observed in 23 procedures (17.4%), 2 mild and 2 moderate (8.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EUS-RFA appears to provide complete symptom resolution and demonstrates a favorable safety profile compared to conventional surgery. However, the long-term efficacy of EUS-RFA remains to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf571","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:37:02Z","timestamp":1760873822000},"page":"988-992","source":"Crossref","is-referenced-by-count":4,"title":["EUS-Guided Radiofrequency Ablation as a Minimally Invasive Treatment for Insulinomas\u2014A Single-Center Experience"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-0544","authenticated-orcid":false,"given":"Bojan","family":"Kovacevic","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital Herlev and Gentofte Gastro Unit, Division of Endoscopy, , DK-2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-1104","authenticated-orcid":false,"given":"Peter","family":"Vilmann","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev and Gentofte Gastro Unit, Division of Endoscopy, , DK-2730 Herlev ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , DK-2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-4602","authenticated-orcid":false,"given":"Lene","family":"Brink","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Herlev and Gentofte Gastro Unit, Division of Endoscopy, , DK-2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-0821","authenticated-orcid":false,"given":"Marianne Christina","family":"Klose","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, Copenhagen University Hospital Rigshospitalet , DK-2100 Copenhagen ,","place":["Denmark"]},{"name":"ENETS center of Excellence, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Paulli","family":"Sonne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Copenhagen University Hospital Herlev and Gentofte , DK-2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-0903","authenticated-orcid":false,"given":"Ulrich","family":"Knigge","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, Copenhagen University Hospital Rigshospitalet , DK-2100 Copenhagen ,","place":["Denmark"]},{"name":"ENETS center of Excellence, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-3516","authenticated-orcid":false,"given":"Mikkel","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , DK-2200 Copenhagen ,","place":["Denmark"]},{"name":"Department of Nephrology and Endocrinology, Copenhagen University Hospital Rigshospitalet , DK-2100 Copenhagen ,","place":["Denmark"]},{"name":"ENETS center of Excellence, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"8","key":"2026031619580959700_dgaf571-B1","doi-asserted-by":"crossref","first-page":"e13318","DOI":"10.1111\/jne.13318","article-title":"European neuroendocrine tumor society 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