{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:18:00Z","timestamp":1792426680141,"version":"4.5.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Previous studies have shown the efficacy and safety of percutaneous laser ablation for the treatment of nontoxic and toxic benign thyroid nodules; however, data on long-term follow-up are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to evaluate the long-term efficacy and safety of percutaneous, ultrasound-guided laser ablation of benign thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between May 2009 and July 2024, 1492 patients underwent a single treatment with laser ablation (nontoxic nodules, N = 1291; toxic nodules, N = 201 [211 nodules]). Nodule volume was assessed before treatment, then every 6 months in the first 3 years and annually thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median durations of follow-up were 10.4 years (range, 1-18 years) for nontoxic nodules and 11.4 years (range, 3-15 years) for toxic nodules. For nontoxic nodules, median volume reduction (VRR) was 70.7% at 1 year, reducing to 64.1% at 10 years. For toxic nodules, the corresponding VRR values were 63.8% and 56.9%, respectively (P &amp;lt; .001 vs pretreatment at all time points). No cases of benign nodule regrowth of 25% or greater occurred during the first 3 years of follow-up. The percentage of patients discontinuing methimazole treatment decreased with increasing nodule volume, from 100% for nodules smaller than 5\u2005mL to 33.3% for nodules larger than 25\u2005mL. No major complications were reported; overall, minor complications consisted of fever (15% of patients), pain (7%), and hematoma (1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the largest cohorts reported to date, ultrasound-guided laser ablation of thyroid lesions showed long-term efficacy and safety for treatment of nontoxic and toxic nodules, based on median follow-ups of 10 years or more.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf581","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:48:27Z","timestamp":1761133707000},"page":"e1023-e1028","source":"Crossref","is-referenced-by-count":2,"title":["Percutaneous Laser Ablation for Thyroid Nodules: Efficacy and Safety in 1492 Patients With Median Follow-up of 10 Years or More"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-4867","authenticated-orcid":false,"given":"Giovanni","family":"Gambelunghe","sequence":"first","affiliation":[{"name":"Endocrine Unit, Clinica Liotti , Perugia 06123 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Del Sindaco","sequence":"additional","affiliation":[{"name":"Diabetes Unit, USL Umbria 1 , Perugia 06127 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Morettini","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Perugia, Perugia 06132 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenella","family":"Ristagno","sequence":"additional","affiliation":[{"name":"Department of Oncology, Section of Endocrine Surgery, Taormina Hospital , Taormina 98039 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"De Feo","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Clinica Liotti , Perugia 06123 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"8","key":"2026031619575971700_dgaf581-B1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2362.2009.02162.x","article-title":"Very high prevalence of thyroid nodules detected by high frequency (13\u2005MHz) ultrasound examination","volume":"39","author":"Guth","year":"2009","journal-title":"Eur J Clin Invest"},{"issue":"Suppl 1","key":"2026031619575971700_dgaf581-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161208.GL","article-title":"American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid modules\u20142016 update. 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