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Light exposure was categorized into daytime and nighttime periods, with exposure durations recorded separately at different threshold levels. The primary outcome was MASLD, with secondary outcomes including fibrosis and cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the UK Biobank prospective analysis, each 0.1-unit and 1-unit increase in RA and M10 were associated with a 30% and 2% reduction of MASLD risk, respectively. In contrast, each 1-unit increase in L5 and delayed L5 onset were linked to an 8% and 21% increase of MASLD risk. Moreover, each additional hour of daylight exposure above 6000 lux was associated with a 9% lower risk of MASLD, while each additional 30\u2005minutes of nocturnal light exposure above 30 lux corresponded to a 22% higher risk of MASLD. Additionally, a favorable 24\u2005h-RAR profile and adequate light exposure were associated with a lower risk of fibrosis and cirrhosis, as well as improved life expectancy among participants with MASLD. Similar associations were observed in the NHANES analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater daytime light exposure, reduced nocturnal light exposure, and regulated RARs may protect against MASLD and prevent its progression to liver fibrosis and advanced liver disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf593","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:49:29Z","timestamp":1761655769000},"page":"1459-1469","source":"Crossref","is-referenced-by-count":9,"title":["Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies"],"prefix":"10.1210","volume":"111","author":[{"given":"Hanzhang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of 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