{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:18:33Z","timestamp":1791494313341,"version":"4.3.4"},"reference-count":19,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000066","name":"Clinician Scientist Program of the Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CRC\/Transregio","award":["205\/1"],"award-info":[{"award-number":["205\/1"]}]},{"DOI":"10.13039\/501100022027","name":"The Adrenal: Central Relay in Health and Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2013_A182"],"award-info":[{"award-number":["2013_A182"]}]},{"name":"German Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2015_A171"],"award-info":[{"award-number":["2015_A171"]}]},{"name":"German Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2019_A104"],"award-info":[{"award-number":["2019_A104"]}]},{"DOI":"10.13039\/100019180","name":"European Research Council under the European Union Horizon 2020","doi-asserted-by":"publisher","award":["694913"],"award-info":[{"award-number":["694913"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CRC\/Transregio","award":["205\/1"],"award-info":[{"award-number":["205\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Suppressed renin concentrations in medically treated patients with primary aldosteronism (PA) are associated with a worse cardiometabolic outcome compared to patients with normalized renin levels. No similar study has been conducted in patients with PA after unilateral adrenalectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the prevalence and impact of persistent renin suppression after unilateral adrenalectomy in patients with lateralized PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included 77 patients who underwent adrenalectomy for lateralized PA. All patients had postoperative renin levels available. Patients were divided into tertiles based on their direct renin concentrations (DRC) (&amp;lt;8\u2005mU\/L, 8-16\u2005mU\/L, &amp;gt;16\u2005mU\/L) at the first follow-up, approximately 6 months after surgery. Study endpoints included histopathology using CYP11B2 staining according to HISTALDO consensus, biochemical and clinical outcomes according to the PASO criteria and improvement of comorbidities and end-organ damage at short- and long-term follow-up up to 3 years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with DRC &amp;lt;8\u2005mU\/L showed a higher prevalence of non-classical histopathology compared to the other 2 tertiles (8\/26 [30.8%] vs 1\/25 [4%] vs 3\/26 [11.5%]; P = .024) and more frequently absent or partial biochemical remission at their first follow-up (9\/26 [34.6%] vs 3\/25 [12.0%] vs 2\/26 [7.7%]; P = .036). Nonetheless, 65.4% achieved complete biochemical remission. Clinical outcomes, including end-organ damage and comorbidities, did not differ across the tertiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent renin suppression is common 6 months after adrenalectomy and associated with worse biochemical but not clinical outcomes. More than 60% of patients with DRC &amp;lt;8\u2005mU\/L achieved full biochemical remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf595","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:05:41Z","timestamp":1761915941000},"page":"e1381-e1387","source":"Crossref","is-referenced-by-count":3,"title":["Persistent Renin Suppression After Unilateral Adrenalectomy for Primary Aldosteronism: Implications for Adverse Outcome?"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6846-6893","authenticated-orcid":false,"given":"Isabel","family":"St\u00fcfchen","sequence":"first","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Ann","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fania R O L","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"V\u00f6lter","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Zopp","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Petersenn","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-6668","authenticated-orcid":false,"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Br\u00fcdgam","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kroiss","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Oettle","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Schrenk","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9875","authenticated-orcid":false,"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"issue":"11","key":"2026042119570893300_dgaf595-B1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41574-022-00730-2","article-title":"Primary aldosteronism\u2014a multidimensional syndrome","volume":"18","author":"Turcu","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"12","key":"2026042119570893300_dgaf595-B2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S2213-8587(21)00210-2","article-title":"Diagnosis and treatment of primary aldosteronism","volume":"9","author":"Reincke","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"2026042119570893300_dgaf595-B3","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1161\/HYPERTENSIONAHA.124.22642","article-title":"Clinical management of primary aldosteronism: an update","volume":"81","author":"Rossi","year":"2024","journal-title":"Hypertension"},{"issue":"4","key":"2026042119570893300_dgaf595-B4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1507\/endocrj.EJ21-0508","article-title":"Japan Endocrine Society clinical practice guideline for the diagnosis and management of primary aldosteronism 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aldosteronism: long-term disease recurrence after adrenalectomy","volume":"81","author":"Tetti","year":"2024","journal-title":"Hypertension"},{"issue":"2","key":"2026042119570893300_dgaf595-B8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00268-019-05265-8","article-title":"Outcomes after surgery for unilateral dominant primary aldosteronism in Sweden","volume":"44","author":"Sellgren","year":"2020","journal-title":"World J Surg"},{"issue":"2","key":"2026042119570893300_dgaf595-B9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S2213-8587(24)00308-5","article-title":"Outcomes after medical treatment for primary aldosteronism: an international consensus and analysis of treatment response in an international cohort","volume":"13","author":"Yang","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"2026042119570893300_dgaf595-B10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.eprac.2024.09.002","article-title":"Suppressed renin Status is a risk factor for cardiocerebrovascular events in bilateral primary aldosteronism treated with mineralocorticoid receptor antagonists","volume":"30","author":"Jiang","year":"2024","journal-title":"Endocr Pract"},{"issue":"1","key":"2026042119570893300_dgaf595-B11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S2213-8587(17)30367-4","article-title":"Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study","volume":"6","author":"Hundemer","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026042119570893300_dgaf595-B12","doi-asserted-by":"crossref","unstructured":"St\u00fcfchen I, Williams TA, Schweizer JROL, et al \u00a0Supplementary Material for \u201cPersistent Renin Suppression After Unilateral 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