{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:02:17Z","timestamp":1785265337113,"version":"3.55.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>There is scarce information on the natural history of gonadal function of testicular disorders\/differences of sex development (T-DSD) and ovotesticular DSD (OT-DSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate gonadal outcome in a large cohort of cases of T-DSD and OT-DSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 29 cases of T-DSD and 32 cases of OT-DSD were identified from 20 centers across 13 countries in the I-DSD Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Male registration at birth occurred in 24 (83%) and 18 (56%) cases of T-DSD and OT-DSD, respectively. Of 42 cases registered as male, there were no cases of sex reassignment, while of 17 cases registered as female, 2 cases of T-DSD were reassigned within the first year of life. In male infants, stretched penile length (SPL) was &amp;lt;5th centile in 11\/15 (73%) and similar in T-DSD and OT-DSD. However, in adolescence, median SPL in boys with OT-DSD (n, 5) and T-DSD (n, 4) was 5\u2005cm (4.8, 7.5) and 9.5\u2005cm (7.5, 12.5), respectively (P &amp;lt; .05). Of the 14 male and 4 female individuals who were aged &amp;gt;14 years, 7 (50%) and 2 (50%), respectively, had spontaneous puberty. In 8\/9 (89%) male and 1\/2 (50%) female adolescents and adults, serum gonadotropins were above reference range. However, in 8\/9 (89%) males, serum testosterone was within the reference range. In 34 cases with available data, gonadal tumors had not been reported at a median age of 11.3 years (1 month, 35.5 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In young adulthood, biochemical evidence of primary gonadal insufficiency is present in the majority of males and females with T-DSD and OT-DSD. In males with OT-DSD, micropenis may persist in young adulthood despite normal testosterone concentration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf603","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:07:12Z","timestamp":1762002432000},"page":"e1356-e1363","source":"Crossref","is-referenced-by-count":1,"title":["Gonadal Function and Its Evolution in 46,XX Testicular\/Ovotesticular DSD"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8642-6448","authenticated-orcid":false,"given":"Margherita","family":"Sepich","sequence":"first","affiliation":[{"name":"Pediatrics Unit, Endocrinology Section, University of Pisa, Pisa University Hospital , Pisa 56126 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Bertelloni","sequence":"additional","affiliation":[{"name":"Pediatrics Unit, Endocrinology Section, University of Pisa, Pisa 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