{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:59:30Z","timestamp":1791237570425,"version":"4.1.0"},"reference-count":51,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD096032"],"award-info":[{"award-number":["R01HD096032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD034568"],"award-info":[{"award-number":["R01HD034568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24ES030894"],"award-info":[{"award-number":["R24ES030894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018332","name":"Harvard Pilgrim Health Care Institute","doi-asserted-by":"publisher","award":["1K23DK131322-01A1"],"award-info":[{"award-number":["1K23DK131322-01A1"]}],"id":[{"id":"10.13039\/100018332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although polycystic ovary syndrome (PCOS) is associated with high body mass index (BMI), less is known about the cardiometabolic manifestations of PCOS without excess adiposity. Among female adolescents enrolled in the Project Viva longitudinal prebirth cohort, we characterized growth, adiposity, and cardiometabolic biomarkers among those with vs without PCOS, stratified by BMI category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We defined PCOS at the mid-teen visit (mean age 17.7 years) as self-reported diagnosis or oligo-anovulation with clinical\/biochemical hyperandrogenism. We obtained anthropometric and dual x-ray absorptiometry measurements. Within each BMI category (\u226585th percentile vs &amp;lt; 85th percentile), we used unadjusted linear regression to compare growth trajectories, adiposity, and cardiometabolic biomarkers among those with vs without PCOS. We used mixed effects models to visually represent estimated BMI and linear growth trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 358 females with data at the mid-teen visit, n = 51 (14%) participants met our criteria for PCOS. Among females with BMI &amp;lt;85th percentile, those with PCOS (n = 27) had earlier age at peak height velocity [\u03b2 = -.57 years; 95% confidence interval (CI) \u22120.96, \u22120.18], higher Homeostatic Model Assessment of Insulin Resistance (\u03b2 = .77, 95% CI 0.23, 1.30), and lower adiponectin-leptin ratio (\u03b2 = \u2212.35, 95% CI \u22120.65, \u22120.06) vs without PCOS. Females with BMI \u226585th percentile had similar biomarkers by PCOS status. Adiposity measures did not differ by PCOS status within either BMI category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within this population-based cohort, adolescents with PCOS and BMI &amp;lt;85th percentile had greater insulin resistance and adipose tissue dysfunction vs without PCOS. PCOS-associated metabolic dysfunction exist even among adolescents with BMI &amp;lt;85th percentile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf606","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:15:12Z","timestamp":1764767712000},"page":"e1364-e1372","source":"Crossref","is-referenced-by-count":7,"title":["Adolescent \u201cLean PCOS\u201d Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6845-4821","authenticated-orcid":false,"given":"Rachel C","family":"Whooten","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Massachusetts General Hospital for Children , Boston, MA 02114 ,","place":["USA"]},{"name":"Division of General Academic, Department of Pediatrics, Massachusetts General Hospital for Children , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-920X","authenticated-orcid":false,"given":"Sheryl L","family":"Rifas-Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzuddin M","family":"Aris","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes Center, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus , Aurora, CO 80045 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E","family":"Chavarro","sequence":"additional","affiliation":[{"name":"Department of Nutrition, T. H. Chan Harvard School of Public Health , Boston, MA 02115 ,","place":["USA"]},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]},{"name":"Department of Nutrition, T. H. Chan Harvard School of Public Health , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston, MA 02215 ,","place":["USA"]},{"name":"Diabetes Unit, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"6","key":"2026042119571853100_dgaf606-B1","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.fertnstert.2016.07.1121","article-title":"Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and 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