{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:15Z","timestamp":1791404895019,"version":"4.3.3"},"reference-count":45,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL145386"],"award-info":[{"award-number":["U01 HL145386"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Disordered eating behaviors are linked to reproductive health and are more common in women with polycystic ovary syndrome (PCOS). However, it remains unclear whether they are risk factors for PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the associations of disordered eating behaviors during adolescence and PCOS in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, longitudinal cohort (1996-2021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients or Other Participants<\/jats:title>\n                    <jats:p>Female participants (n = 6208) from the Growing Up Today Study. Disordered eating behaviors were self-reported on repeated questionnaires during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Physician-diagnosed PCOS was reported on each questionnaire starting in 2010. Multivariable logistic regression with generalized estimating equations to calculate the adjusted odds ratios (aOR) and 95% confidence intervals (CIs) for the association between past-year frequency of binge eating, laxative use, and self-induced vomiting and PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 410 cases (7%) of PCOS. Binge eating was the most common behavior, with 2331 (38%) girls binge eating at least once during follow-up. Additionally, 1103 (18%) girls reported self-induced vomiting and 701 (11%) reported using laxatives for weight control at least once. Compared to girls who never binge ate, cumulative binge eating more than monthly was associated with higher odds of PCOS (aOR: 1.59, 95% CI: 1.09, 2.33). Cumulative laxative use less than monthly was associated with lower odds of PCOS (aOR: 0.45, 95% CI: 0.29, 0.72) while at least monthly laxative use was associated with higher odds of PCOS (aOR: 1.67, 95% CI: 0.89, 3.14). Self-induced vomiting was not associated with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Girls who binge eat during adolescence may have increased odds of developing PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf609","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:55:39Z","timestamp":1764680139000},"page":"e1373-e1380","source":"Crossref","is-referenced-by-count":3,"title":["Disordered Eating Behaviors During Adolescence and Risk of Polycystic Ovary Syndrome: A Prospective Cohort Study"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-6557","authenticated-orcid":false,"given":"Sarah","family":"Thornburgh","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Emory University Rollins School of Public Health , Atlanta, GA 30322 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-8175","authenticated-orcid":false,"given":"Ashley I","family":"Naimi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Emory University Rollins School of Public Health , Atlanta, GA 30322 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendrin R","family":"Sonneville","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Michigan School of Public Health , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E","family":"Chavarro","sequence":"additional","affiliation":[{"name":"Departments of Nutrition and Epidemiology, Harvard T.H. 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