{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:57:27Z","timestamp":1776855447535,"version":"3.51.2"},"reference-count":42,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF0064985"],"award-info":[{"award-number":["NNF0064985"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laboratory Endowment Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Brown adipose tissue (BAT) is a thermogenic tissue that converts energy into heat in response to cold exposure, and is therefore a promising target for improving cardiometabolic health. Habitually cold-exposed Arctic people represent a unique model of metabolic adaptation to cold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated cold-induced BAT activation in Greenlanders in comparison to Danes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comparative crossover study was conducted of 13 Greenlanders and 11 Danes, with 2 experimental sessions conducted 2 weeks apart: A, a thermoneutral session; and B, a cooling session. BAT volume and activity were assessed using 2-deoxy-2-[18F]-fluoro-D-glucose ([18F]FDG) positron emission tomography\/computed tomography (PET\/CT) imaging. Serial measurement of metabolic markers associated with BAT activity was performed by blood sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both for Greenlanders and Danes, core temperature decreased 0.5 \u00b0C during cooling, and the volume of active BAT increased, yet with a higher increase in active BAT volume of 16 917% in Greenlanders compared to 4541% in Danes (P = .046). Marked differences in glucose levels were seen in Greenlanders and Danes in response to cooling (Danes: 0.30 mmol\/L, P = .013; Greenlanders: 0.16 mmol\/L, P = .12), insulin (Danes: 2.43 pmol\/L, P = .32; Greenlanders: 6.65 pmol\/L, P = .001), triglycerides (Danes: \u22120.59 mmol\/L, P &amp;lt; .001; Greenlanders: \u22120.16 pmol\/L, P = .21), and total cholesterol (Danes: 0.39 mmol\/L, P &amp;lt; .001; Greenlanders: 0.02 mmol\/L, P = .89).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The larger increase in BAT activity in response to cooling and the dampened response in metabolic parameters in Greenlanders compared to Danes leads to a hypothesis of preparedness for rapid thermogenic response to cold exposure in populations with active BAT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf615","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T12:53:53Z","timestamp":1763211233000},"page":"e1331-e1342","source":"Crossref","is-referenced-by-count":1,"title":["Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4129-2218","authenticated-orcid":false,"given":"Mette","family":"Motzfeldt Jensen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9000 ,","place":["Denmark"]},{"name":"Greenland Center for Health Research, Ilisimatusarfik, University of Greenland , Nuuk 3900, Greenland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-9160","authenticated-orcid":false,"given":"Charlotte Elberling","family":"Almasi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9000 ,","place":["Denmark"]},{"name":"Department of Nuclear Medicine, Aalborg University Hospital , Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-7638","authenticated-orcid":false,"given":"Benedict","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9000 ,","place":["Denmark"]},{"name":"Biomedical Research Laboratory, Aalborg University Hospital , Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-145X","authenticated-orcid":false,"given":"Bodil Steen","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9000 ,","place":["Denmark"]},{"name":"Department of Anesthesia and Intensive Care, Aalborg University Hospital , Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-1469","authenticated-orcid":false,"given":"Mette Korre","family":"Andersen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2401-9921","authenticated-orcid":false,"given":"Mikkel","family":"Schubert","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-3831","authenticated-orcid":false,"given":"Torben","family":"Hansen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-4375","authenticated-orcid":false,"given":"Christina","family":"Ellervik","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Zealand University Hospital , Aalborg 9000 ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]},{"name":"Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School , Boston, MA 02115 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-9709","authenticated-orcid":false,"given":"Camilla","family":"Sch\u00e9ele","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen 2200 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-5565","authenticated-orcid":false,"given":"Marit Eika","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Greenland Center for Health Research, Ilisimatusarfik, University of Greenland , Nuuk 3900, Greenland"},{"name":"Steno Diabetes Center Greenland, Queen Ingrids Hospital , Nuuk 3900, Greenland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-5213","authenticated-orcid":false,"given":"Stig","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9000 ,","place":["Denmark"]},{"name":"Greenland Center for Health Research, Ilisimatusarfik, University of Greenland , Nuuk 3900, Greenland"},{"name":"Department of Geriatric Medicine, Aalborg University Hospital , Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"issue":"1","key":"2026042119570007200_dgaf615-B1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"issue":"15","key":"2026042119570007200_dgaf615-B2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"2026042119570007200_dgaf615-B3","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","volume":"360","author":"Virtanen","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"2026042119570007200_dgaf615-B4","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N Engl J Med"},{"issue":"8","key":"2026042119570007200_dgaf615-B5","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1172\/JCI67803","article-title":"Recruited brown adipose tissue as an antiobesity agent in humans","volume":"123","author":"Yoneshiro","year":"2013","journal-title":"J Clin Invest"},{"issue":"1","key":"2026042119570007200_dgaf615-B6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41591-020-1126-7","article-title":"Brown adipose tissue is associated with cardiometabolic health","volume":"27","author":"Becher","year":"2021","journal-title":"Nat Med"},{"issue":"8","key":"2026042119570007200_dgaf615-B7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nm.3891","article-title":"Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus","volume":"21","author":"Hanssen","year":"2015","journal-title":"Nat Med"},{"issue":"2","key":"2026042119570007200_dgaf615-B8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"issue":"10","key":"2026042119570007200_dgaf615-B9","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nm.3361","article-title":"Brown and beige fat: development, function and therapeutic potential","volume":"19","author":"Harms","year":"2013","journal-title":"Nat Med"},{"issue":"6254","key":"2026042119570007200_dgaf615-B10","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.aab2319","article-title":"Greenlandic inuit show genetic signatures of diet and climate adaptation","volume":"349","author":"Fumagalli","year":"2015","journal-title":"Science"},{"issue":"7513","key":"2026042119570007200_dgaf615-B11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature13425","article-title":"A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes","volume":"512","author":"Moltke","year":"2014","journal-title":"Nature"},{"issue":"6","key":"2026042119570007200_dgaf615-B12","doi-asserted-by":"crossref","first-page":"e1006119","DOI":"10.1371\/journal.pgen.1006119","article-title":"Identification of novel genetic determinants of erythrocyte membrane fatty acid composition among Greenlanders","volume":"12","author":"Andersen","year":"2016","journal-title":"PLoS Genet"},{"issue":"12","key":"2026042119570007200_dgaf615-B13","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/sj.ijo.0802434","article-title":"Obesity and central fat pattern among Greenland Inuit and a general population of Denmark (Inter99): relationship to metabolic risk factors","volume":"27","author":"J\u00f8rgensen","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"10","key":"2026042119570007200_dgaf615-B14","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.2337\/dc12-2703","article-title":"Fat distribution and glucose intolerance among Greenland Inuit","volume":"36","author":"Jorgensen","year":"2013","journal-title":"Diabetes Care"},{"issue":"Suppl. 1","key":"2026042119570007200_dgaf615-B15","doi-asserted-by":"crossref","first-page":"21086","DOI":"10.3402\/ijch.v72i0.21086","article-title":"Raised BMI cut-off for overweight in Greenland Inuit\u2014a review","volume":"72","author":"Andersen","year":"2013","journal-title":"Int J Circumpolar Health"},{"issue":"1","key":"2026042119570007200_dgaf615-B16","doi-asserted-by":"crossref","first-page":"2545059","DOI":"10.1080\/22423982.2025.2545059","article-title":"Effect of habitual cold exposure on brown adipose tissue activity in Arctic adults: a systematic review","volume":"84","author":"Motzfeldt Jensen","year":"2025","journal-title":"Int J Circumpolar Health"},{"issue":"1","key":"2026042119570007200_dgaf615-B17","doi-asserted-by":"crossref","first-page":"2545662","DOI":"10.1080\/22423982.2025.2545662","article-title":"Cross-over comparative study of cold-induced brown adipose tissue activity in Greenlandic Inuit and Danes: rationale, design, and methodology","volume":"84","author":"Motzfeldt Jensen","year":"2025","journal-title":"Int J Circumpolar Health"},{"issue":"2","key":"2026042119570007200_dgaf615-B18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cmet.2016.07.014","article-title":"Brown adipose reporting criteria in imaging STudies (BARCIST 1.0): recommendations for standardized FDG-PET\/CT experiments in humans","volume":"24","author":"Chen","year":"2016","journal-title":"Cell Metab Cell Press"},{"issue":"146","key":"2026042119570007200_dgaf615-B19","doi-asserted-by":"publisher","DOI":"10.3791\/58469","article-title":"Whole body and regional quantification of active human brown adipose tissue using 18F-FDG PET\/CT","author":"Kim","year":"2019","journal-title":"J Vis Exp"},{"key":"2026042119570007200_dgaf615-B20","doi-asserted-by":"crossref","first-page":"1128850","DOI":"10.3389\/fgene.2023.1128850","article-title":"Identifying the genetic causes of phenotypically diagnosed Pakistani mucopolysaccharidoses patients by whole genome sequencing","volume":"14","author":"Gul","year":"2023","journal-title":"Front Genet"},{"issue":"9","key":"2026042119570007200_dgaf615-B21","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"Alexander","year":"2009","journal-title":"Genome Res"},{"issue":"8054","key":"2026042119570007200_dgaf615-B22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41586-024-08516-4","article-title":"Genetic architecture in Greenland is shaped by demography, structure and selection","volume":"639","author":"St\u00e6ger","year":"2025","journal-title":"Nature"},{"key":"2026042119570007200_dgaf615-B23","doi-asserted-by":"crossref","unstructured":"Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4(1):7.","DOI":"10.1186\/s13742-015-0047-8"},{"issue":"32","key":"2026042119570007200_dgaf615-B24","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1073\/pnas.1705287114","article-title":"Mapping of human brown adipose tissue in lean and obese young men","volume":"114","author":"Leitner","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026042119570007200_dgaf615-B25","doi-asserted-by":"crossref","unstructured":"Motzfeldt Jensen M, Almasi CE, Kj\u00e6rgaard B, et al \u00a0Supplementary data for \u201cBrown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation\u201d. Figshare. Dataset. 2025. 10.6084\/m9.figshare.30472106","DOI":"10.1210\/clinem\/dgaf615"},{"issue":"4","key":"2026042119570007200_dgaf615-B26","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s42255-025-01249-2","article-title":"Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans","volume":"7","author":"Yoneshiro","year":"2025","journal-title":"Nat Metab"},{"issue":"4","key":"2026042119570007200_dgaf615-B27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/ajpa.24297","article-title":"Evidence for a sensitive period of plasticity in brown adipose tissue during early childhood among indigenous Siberians","volume":"175","author":"Levy","year":"2021","journal-title":"Am J Phys Anthropol"},{"issue":"11","key":"2026042119570007200_dgaf615-B28","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1210\/jc.2016-2670","article-title":"Adipocyte browning and higher mitochondrial function in periadrenal but not SC fat in pheochromocytoma","volume":"101","author":"Vergnes","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"7903","key":"2026042119570007200_dgaf615-B29","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"issue":"12","key":"2026042119570007200_dgaf615-B30","doi-asserted-by":"crossref","first-page":"E2772","DOI":"10.1210\/jc.2014-2440","article-title":"The effects of temperature and seasons on subcutaneous white adipose tissue in humans: evidence for thermogenic gene induction","volume":"99","author":"Kern","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026042119570007200_dgaf615-B31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cell.2015.09.035","article-title":"A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat","volume":"163","author":"Kazak","year":"2015","journal-title":"Cell"},{"issue":"3","key":"2026042119570007200_dgaf615-B32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/BCJ20190463","article-title":"UCP1-independent thermogenesis","volume":"477","author":"Roesler","year":"2020","journal-title":"Biochem J"},{"issue":"1","key":"2026042119570007200_dgaf615-B33","doi-asserted-by":"crossref","first-page":"15485","DOI":"10.1038\/s41598-023-42537-9","article-title":"In-vivo detection of white adipose tissue browning: a multimodality imaging approach","volume":"13","author":"Holmes","year":"2023","journal-title":"Sci Rep"},{"issue":"2","key":"2026042119570007200_dgaf615-B34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nm.2297","article-title":"Brown adipose tissue activity controls triglyceride clearance","volume":"17","author":"Bartelt","year":"2011","journal-title":"Nat Med"},{"issue":"1","key":"2026042119570007200_dgaf615-B35","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1038\/ncomms7356","article-title":"Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development","volume":"6","author":"Berb\u00e9e","year":"2015","journal-title":"Nat Commun"},{"issue":"6","key":"2026042119570007200_dgaf615-B36","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmet.2016.04.029","article-title":"Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans","volume":"23","author":"Chondronikola","year":"2016","journal-title":"Cell Metab"},{"issue":"5","key":"2026042119570007200_dgaf615-B37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41366-023-01270-z","article-title":"Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue","volume":"47","author":"van Beek","year":"2023","journal-title":"Int J Obes Springer Nature"},{"issue":"2","key":"2026042119570007200_dgaf615-B38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cmet.2011.06.012","article-title":"Different metabolic responses of human brown adipose tissue to activation by cold and insulin","volume":"14","author":"Orava","year":"2011","journal-title":"Cell Metab"},{"issue":"2","key":"2026042119570007200_dgaf615-B39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00582100","article-title":"Rapid rise in plasma glucagon induced by acute cold exposure in man and rat","volume":"389","author":"Seitz","year":"1981","journal-title":"Pflugers Arch"},{"issue":"5","key":"2026042119570007200_dgaf615-B40","doi-asserted-by":"crossref","first-page":"e13592","DOI":"10.14814\/phy2.13592","article-title":"Cold acclimation reduces hepatic protein kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in rats","volume":"6","author":"Sepa-Kishi","year":"2018","journal-title":"Physiol Rep"},{"key":"2026042119570007200_dgaf615-B41","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fendo.2018.00447","article-title":"Brown adipose tissue energy metabolism in humans","volume":"9","author":"Carpentier","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026042119570007200_dgaf615-B42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ymeth.2017.05.001","article-title":"Brown adipose tissue and lipid metabolism imaging","volume":"130","author":"Paulus","year":"2017","journal-title":"Methods"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaf615\/65353571\/dgaf615.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/5\/e1331\/65353571\/dgaf615.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/5\/e1331\/65353571\/dgaf615.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:57:13Z","timestamp":1776815833000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/5\/e1331\/8324870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11,17]]},"published-print":{"date-parts":[[2026,4,22]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaf615","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,11,17]]}}}