{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:24:38Z","timestamp":1789565078829,"version":"build-2803163510"},"reference-count":104,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00584"],"award-info":[{"award-number":["PI19\/00584"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01404"],"award-info":[{"award-number":["PI22\/01404"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PMP22\/00021"],"award-info":[{"award-number":["PMP22\/00021"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Primary central nervous system lymphoma (PCNSL) is a rare malignancy that may involve the hypothalamic-pituitary axis (HPA), leading to underrecognized but clinically significant endocrine dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aims to characterize the spectrum and patterns of HPA-related endocrine disturbances in patients with PCNSL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, EMBASE, Scopus, and Web of Science, supplemented by gray literature. The search concluded in February 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>We included studies reporting adult PCNSL cases with documented dysfunction of at least one hormonal axis. Exclusion criteria were preexisting hypopituitarism or lack of endocrine data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Data on demographics, tumor localization, hormonal axes affected, radiological findings, treatment, and outcomes were extracted. Risk of bias was assessed using JBI tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-nine cases met the inclusion criteria. Diffuse large B-cell lymphoma accounted for 84% of cases. Endocrine dysfunction included isolated adenohypophyseal involvement (46%), neurohypophyseal (8%), and combined (45%). The most affected pituitary axes were the gonadal and thyroid axes, with 89.7% and 89.2% involvement, respectively. Hypothalamic tumors were strongly associated with combined dysfunction (odds ratio = 9.47; 95% CI, 3.76-23.86; P &amp;lt; .001). Persistent endocrinopathy was more frequent in progressive disease. No direct association was found between endocrine dysfunction and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HPA dysfunction in PCNSL is frequent and often underdiagnosed. Hypothalamic involvement is associated broader hormonal impairment. Routine hormonal screening and multidisciplinary management should be standard in PCNSL care to minimize complications and improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf620","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:05:50Z","timestamp":1762952750000},"page":"2720-2736","source":"Crossref","is-referenced-by-count":0,"title":["Hypothalamic-Pituitary Axis Involvement in Primary Central Nervous System Lymphoma"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9737-2845","authenticated-orcid":false,"given":"Carolina","family":"Sager-La Ganga","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, Universidad Aut\u00f3noma de Madrid , Madrid 28006 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8138-4178","authenticated-orcid":false,"given":"V\u00edctor","family":"Navas-Moreno","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, Universidad Aut\u00f3noma de Madrid , Madrid 28006 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-0483","authenticated-orcid":false,"given":"Fernando","family":"Sebasti\u00e1n-Valles","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, Universidad Aut\u00f3noma de Madrid , Madrid 28006 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-2279","authenticated-orcid":false,"given":"Jimena","family":"Cannata-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, Universidad Aut\u00f3noma de Madrid , Madrid 28006 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-9618","authenticated-orcid":false,"given":"M\u00f3nica","family":"Marazuela","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, Universidad Aut\u00f3noma de Madrid , Madrid 28006 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"7","key":"2026091519584644100_dgaf620-B1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"issue":"2","key":"2026091519584644100_dgaf620-B2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.seminhematol.2021.02.003","article-title":"Primary and secondary central nervous system mature T- and NK-cell lymphomas","volume":"58","author":"Pang","year":"2021","journal-title":"Semin Hematol"},{"issue":"1","key":"2026091519584644100_dgaf620-B3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41572-023-00439-0","article-title":"Primary central nervous system lymphoma","volume":"9","author":"Ferreri","year":"2023","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"2026091519584644100_dgaf620-B4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11060-020-03422-x","article-title":"Primary central nervous system lymphoma involving the hypothalamic\u2013pituitary axis: a case series and pooled analysis","volume":"147","author":"Shin","year":"2020","journal-title":"J Neurooncol"},{"key":"2026091519584644100_dgaf620-B5","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2026091519584644100_dgaf620-B6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J Clin Epidemiol"},{"key":"2026091519584644100_dgaf620-B7","article-title":"Supplementary material for: hypothalamic\u2013pituitary axis involvement in primary central nervous system lymphoma: a systematic review. 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