{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:28:47Z","timestamp":1782534527355,"version":"3.54.5"},"reference-count":54,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["837004021"],"award-info":[{"award-number":["837004021"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>In children with idiopathic isolated growth hormone deficiency (IIGHD), GH secretion often normalizes by near adult height (NAH). Whether recombinant human GH (rhGH) treatment can be safely discontinued earlier remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to investigate if withdrawing rhGH treatment from mid-puberty onward had no negative effect on attained NAH in adolescents who, after retesting, were no longer GH deficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective multicenter patient preference study was conducted at pediatric endocrinology departments in multiple centers (2017-2024) with follow-up until NAH (SEENEZ GH Study). Participants included 127 adolescents (95 male, 75%) with childhood IIGHD (GH peak 1.7-10\u2005\u00b5g\/L) who tested GH sufficient (GH peak &amp;gt;6.7\u2005\u00b5g\/L) at mid-puberty. Forty-four continued rhGH (GHcont), 83 discontinued (GHstop). A total of 99% of patients completed the study. Intervention included rhGH treatment continuation vs discontinuation from mid-puberty until NAH. The primary outcome measure was NAH-SDS minus target height (TH)-SDS. The secondary outcome was NAH-SDS, total pubertal growth (TPG), and predicted vs attained height gain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean (SD) NAH-SDS minus TH-SDS was \u22120.17 (0.60) in the GHcont and \u22120.18 (0.62) in the GHstop group (P = .96). Mean NAH-SDS was \u22120.91 (0.76) (GHcont) vs \u22120.78 (0.76) (GHstop) (P = .35). Mean (SD) TPG (from start of puberty) in males was 27.5\u2005cm (7.0; GHcont) vs 25.9\u2005cm (6.2; GHstop) (P = .25) and in females 20.5\u2005cm (5.7; GHcont) vs 20.9\u2005cm (7.6; GHstop) (P = .90). Predicted vs attained height gain based on the prediction model did not differ between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adolescents with transient IIGHD, rhGH treatment can be stopped at mid-puberty. These findings support reducing rhGH treatment duration, lowering patient burden and health-care costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf626","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:08:26Z","timestamp":1763125706000},"page":"1319-1328","source":"Crossref","is-referenced-by-count":2,"title":["Growth Hormone Withdrawal in Mid-Puberty: No Impact on Near Adult Height in Adolescents With Transient Idiopathic GHD"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-8595","authenticated-orcid":false,"given":"Joeri","family":"Vliegenthart","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Erasmus University Medical Centre, Sophia Children's Hospital , 3015 GD Rotterdam ,","place":["the 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Pediatric Endocrinology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Centre Groningen , 9713 GZ Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-2261","authenticated-orcid":false,"given":"Christiaan","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre , 2333 ZG Leiden ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6589-9788","authenticated-orcid":false,"given":"Martijn J J","family":"Finken","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Center , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6074-6005","authenticated-orcid":false,"given":"Josine C","family":"van der Heyden","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Franciscus Gasthuis & Vlietland , 3045 PM Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-7628","authenticated-orcid":false,"given":"Anita C S","family":"Hokken-Koelega","sequence":"additional","affiliation":[{"name":"Dutch Growth Research Foundation , 3016 AH Rotterdam ,","place":["the Netherlands"]},{"name":"Department of Pediatrics, Erasmus University Medical Centre, Sophia Children's Hospital , 3015 GD Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hetty J","family":"van der Kamp","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht , 3584 CX Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-0730","authenticated-orcid":false,"given":"Edgar G","family":"van Mil","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Jeroen Bosch Hospital , 5223 GZ \u2018s-Hertogenbosch ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-1385","authenticated-orcid":false,"given":"Theo C J","family":"Sas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Erasmus University Medical Centre, Sophia Children's Hospital , 3015 GD Rotterdam ,","place":["the 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Pediatric Endocrinology, Department of Pediatrics, Maastricht University Medical Centre , 6229 HX Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"van Tellingen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Catharina Hospital , 5623 EJ Eindhoven ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-932X","authenticated-orcid":false,"given":"Robbert N H","family":"Touwslager","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, St. Antonius Hospital , 3543 AZ Nieuwegein ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-7441","authenticated-orcid":false,"given":"A S Paul","family":"van 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