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<jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Repeated measures modified Poisson regression estimated the associations of early perimenopausal levels of (1) AMH or CTX (in separate models), or (2) AMH and CTX (in a single model) with fast, imminent BMD loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Study of Women's Health Across the Nation (community-based cohort).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 436 early perimenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Fast, imminent BMD loss (at lumbar spine [LS], femoral neck [FN], or total hip [TH]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In separate models, adjusted for age, body mass index, cigarette use, race\/ethnicity and study site, lesser AMH or greater CTX individually related to greater fast, imminent BMD loss risk. As predictors in a single model, lesser AMH and greater CTX remained independently associated with fast, imminent BMD loss. Per SD decrement in log-transformed AMH, fast BMD decline risk was 45% (LS), 17% (FN), and 26% (TH) greater (each P &amp;lt; .0001). Per SD increment in log-transformed CTX, fast BMD loss risk was 35% (LS), 23% (FN), and 34% (TH) greater (each P &amp;lt; .0001). Model areas under the curve was greater for models with AMH and CTX vs those for models with AMH or CTX individually (P &amp;lt; .001 for each BMD site-specific comparison).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining AMH and CTX affords stronger prediction of fast, imminent BMD loss than using AMH or CTX individually.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf658","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:05:10Z","timestamp":1765458310000},"page":"e1653-e1661","source":"Crossref","is-referenced-by-count":2,"title":["Anti-Mullerian Hormone and Collagen Type I C-telopeptide Predict Fast, Imminent Bone Loss in Early Perimenopause: 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