{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:46:17Z","timestamp":1789677977550,"version":"4.0.1"},"reference-count":45,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Brigham and Women\u2019s Hospital Department of Medicine Innovation Evergreen Fund Award"},{"name":"American Heart Association Career Development Award","award":["CDA852429"],"award-info":[{"award-number":["CDA852429"]}]},{"name":"National Institutes of Health\/National Heart, Lung, and Blood Institute","award":["K23HL159279"],"award-info":[{"award-number":["K23HL159279"]}]},{"name":"National Institutes of Health\/National Heart, Lung, and Blood Institute","award":["T32HL007609"],"award-info":[{"award-number":["T32HL007609"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK115392"],"award-info":[{"award-number":["R01DK115392"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL153004"],"award-info":[{"award-number":["R01HL153004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL155834"],"award-info":[{"award-number":["R01HL155834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) is a common, targetable cause of hypertension and cardiovascular risk, but &amp;lt;2% of eligible patients are tested, and Hispanic\/Latino patients are underrepresented in PA research and care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We expanded a nationwide, direct-to-patient PA testing program to reach Spanish-speaking adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Spanish-speaking adults with PA testing indications were recruited from Boston, New York, Miami, Houston, and Los Angeles\/San Diego. Participants underwent virtual medical history review in Spanish and local phlebotomy for PA testing, with laboratory interpretations communicated to patients and clinicians. Participants were followed up at 6 months. The primary outcome was the frequency of a positive PA test. Secondary outcomes included clinical PA testing, initiation of aldosterone-targeted therapies, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population (N = 155) spoke fluent Spanish, with 77.4% reporting limited English proficiency. Of the participants, 30.3% tested positive for PA. Leading PA testing indications were family history of premature hypertension or stroke and sleep apnea. Among participants who tested positive and provided follow-up (n = 29), 10.3% underwent additional testing for PA, and 10.3% started a mineralocorticoid receptor antagonist. Participants cited access to care and clinician dismissal of results as barriers to clinical action; however, study participation was positively rated to enhance health awareness and interest in research participation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This Spanish-language, direct-to-patient PA testing program effectively reached patients for testing, identified possible PA in over 30%, and influenced downstream care. Language-concordant PA testing initiatives can help to address the high prevalence of hypertension and PA in the US Hispanic\/Latino population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf663","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:15:23Z","timestamp":1765372523000},"page":"e1263-e1272","source":"Crossref","is-referenced-by-count":2,"title":["Implementation of a Spanish-language, direct-to-patient primary aldosteronism testing program"],"prefix":"10.1210","volume":"111","author":[{"given":"Arnaldo","family":"Ferrebus","sequence":"first","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School , Boston, MA 02115 ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA 02115 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,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School , Boston, MA 02115 ,","place":["USA"]},{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 ,","place":["Taiwan"]},{"name":"Department of Internal Medicine, Primary Aldosteronism Center at National Taiwan University Hospital , Taipei 100 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-9252","authenticated-orcid":false,"given":"Anand","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's 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