{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:52:03Z","timestamp":1780534323393,"version":"3.54.1"},"reference-count":61,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NIH\/NHLBI","doi-asserted-by":"publisher","award":["1K23HL147799-01"],"award-info":[{"award-number":["1K23HL147799-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the metabolic effects of GAHT ie, estradiol with anti-androgen therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study with a 12-month follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic medical center in greater Boston, Massachusetts, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Twenty-six transgender women and nonbinary individuals with no history of cardiovascular disease or diabetes who were either planning to initiate or who had recently initiated GAHT consisting of 17 beta(\u03b2)-estradiol and anti-androgen therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention(s)<\/jats:title>\n                    <jats:p>GAHT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>The prespecified primary outcome was the change in visceral adipose tissue (VAT). Prespecified secondary outcomes included change in bone density, insulin sensitivity, and intrahepatic triglyceride content (hTG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age of participants was 26 (20, 30) years. After 12 months, VAT mass and volume did not change. While lumbar, total hip, and femoral bone density increased, insulin sensitivity did not change. hTG decreased over 12 months (median change: \u22120.2 [\u22121.3, 0.1]%, P = .03). Total lean body mass and the appendicular lean body mass\/height2 decreased (mean change: \u22120.31 \u00b1 0.38\u2005kg\/m2, P = .0003). Systemic triglycerides levels increased, whereas high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, did not change over 12 months. Free testosterone levels at follow-up independently predicted the change in hTG, controlling for estradiol levels, body mass index, and waist-to-hip ratio at follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Key indices of metabolic health, such as VAT and insulin sensitivity, did not change after 12 months of GAHT. Appendicular lean body mass\/height2, a predictor of sarcopenia, unfavorably decreased, while hTG favorably decreased. Awareness of the metabolic effects of GAHT may lead to the implementation of strategies aimed at mitigating sarcopenia risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaf665","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:13:20Z","timestamp":1765458800000},"page":"1713-1726","source":"Crossref","is-referenced-by-count":1,"title":["Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort"],"prefix":"10.1210","volume":"111","author":[{"given":"Ria","family":"Talathi","sequence":"first","affiliation":[{"name":"Metabolism Unit, Division of Endocrinology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vencel","family":"Juhasz","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center (CIRC), Department of Radiology and 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