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It is unclear if this excess risk upon outcomes is attributable to PCOS, more severe hyperglycemia, higher maternal BMI or reduced efficacy of dietary interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess associations of PCOS, dietary intervention and gestational weight loss with maternal and neonatal outcomes in women with GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Design<\/jats:title>\n                    <jats:p>A secondary analysis from the DiGest double-blind randomized controlled trial. Data on self-reported PCOS status were collected at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Pregnant women with GDM and BMI \u226525 kg\/m2 from 8 UK centers (N = 425; 50 with PCOS and 375 without PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Reduced-energy intervention diet (1200 kcal\/day) or standard-energy control diet (2000 kcal\/day) from enrollment (29 weeks) until delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Pregnancy outcomes, including maternal weight and continuous glucose metrics, physical and dietary data, and infant birthweight and jaundice, were compared between women with and without PCOS using univariate tests and multivariable regression models were applied for adjusted analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women with GDM and PCOS had similar baseline characteristics, glycemia, BMI, and pregnancy outcomes compared with women with GDM alone, but their infants had higher rates of neonatal jaundice (24.4% vs 8.9%, P = .002). Outcomes across the dietary interventions were similar in women with and without PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In women with GDM, PCOS was not associated with increased risks for most suboptimal pregnancy outcomes or reduced efficacy of a dietary intervention in this cohort where BMI and glycemia were comparable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag026","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T12:38:19Z","timestamp":1769258299000},"page":"2027-2038","source":"Crossref","is-referenced-by-count":1,"title":["Association between polycystic ovary syndrome and pregnancy outcomes in GDM: A secondary analysis of the DiGest trial"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3164-1106","authenticated-orcid":false,"given":"Laura C","family":"Kusinski","sequence":"first","affiliation":[{"name":"Leicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital , Leicester LE5 4PW ,","place":["UK"]},{"name":"Institute of Metabolic Science\u2014Medical Research Laboratories, University of Cambridge , Cambridge CB2 0QQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"Leicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital , Leicester LE5 4PW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dib","sequence":"additional","affiliation":[{"name":"Leicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital , Leicester LE5 4PW 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