{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:51:49Z","timestamp":1781657509742,"version":"3.54.5"},"reference-count":52,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012589","name":"Fondation IUCPQ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007867","name":"Universit\u00e9 Laval","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Genome-wide association studies (GWAS) have identified dozens of genetic loci linked with metabolic dysfunction\u2013associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify liver-expressed genes that may represent therapeutic candidates for MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a new GWAS meta-analysis including 16 532 cases and 1 240 188 controls. We also generated RNA sequencing data of liver samples and genome-wide genotyping of 504 individuals of the Quebec Obesity Biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using mendelian randomization (MR) and genetic colocalization, we confirm the implication of genes previously linked with MASLD and identified novel ones including AKNA (AT-hook transcription factor), EPHA2 (EPH receptor A2), CHEK2 (encoding checkpoint kinase 2), and PCCB (propionyl-CoA carboxylase subunit \u03b2). More specifically, we found a strong and positive effect of long noncoding (lnc)RNA TRIB1AL on MASLD. The lead genetic variant was not linked with expression levels of the nearby protein-coding gene TRIB1 (Tribbles pseudokinase 1). In UK Biobank participants with whole-exome sequencing data available, rare loss-of-function variants in TRIB1 were not associated with liver fat accumulation or plasma triglyceride levels, suggesting that the lncRNA TRIB1AL may carry cardiometabolic effects independently of TRIB1. Targeted- and phenome-wide MR also identified lower liver-expressed TRIB1AL as being associated with reduced liver fat accumulation, lower plasma lipoprotein-lipid levels, and decreased atherosclerotic cardiovascular disease risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results open the door to liver-targeted therapeutics silencing of the noncoding genome for the prevention and treatment of MASLD and cardiometabolic diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag043","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:33:07Z","timestamp":1770121987000},"page":"1980-1993","source":"Crossref","is-referenced-by-count":1,"title":["Integrative genetic and liver transcriptomic analyses identify\n                    <i>TRIB1AL<\/i>\n                    as a target for steatotic liver disease"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-0731","authenticated-orcid":false,"given":"\u00c9milie","family":"Gobeil","sequence":"first","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-353X","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Bourgault","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-1371","authenticated-orcid":false,"given":"Eloi","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-7762","authenticated-orcid":false,"given":"Nolwenn","family":"Samson","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-7315","authenticated-orcid":false,"given":"Louis-Jacques","family":"Ruel","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8951-7826","authenticated-orcid":false,"given":"Val\u00e9rie","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-1047","authenticated-orcid":false,"given":"Patricia L","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-7030","authenticated-orcid":false,"given":"Clarisse","family":"Gotti","sequence":"additional","affiliation":[{"name":"Proteomics Platform, CHU de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center , Qu\u00e9bec, QC G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-8964","authenticated-orcid":false,"given":"Florence","family":"Roux-Dalvai","sequence":"additional","affiliation":[{"name":"Proteomics Platform, CHU de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center , Qu\u00e9bec, QC G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-790X","authenticated-orcid":false,"given":"Arnaud","family":"Droit","sequence":"additional","affiliation":[{"name":"Proteomics Platform, CHU de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center , Qu\u00e9bec, QC G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-3711","authenticated-orcid":false,"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Department of Molecular Medicine, Faculty of Medicine, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-2004","authenticated-orcid":false,"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Department of Surgery, Faculty of Medicine, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4036-7854","authenticated-orcid":false,"given":"Fannie","family":"Lajeunesse-Trempe","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-5848","authenticated-orcid":false,"given":"Marie-Claude","family":"Vohl","sequence":"additional","affiliation":[{"name":"School of Nutrition, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]},{"name":"Centre Nutrition, sant\u00e9 et soci\u00e9t\u00e9, Institut sur la nutrition et les aliments fonctionnels, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-6136","authenticated-orcid":false,"given":"Alexandre","family":"Caron","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2587-1000","authenticated-orcid":false,"given":"Andr\u00e9","family":"Tchernof","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"School of Nutrition, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1893-8307","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Th\u00e9riault","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-6741","authenticated-orcid":false,"given":"Mathieu","family":"Laplante","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-8456","authenticated-orcid":false,"given":"Benoit J","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 4G5 ,","place":["Canada"]},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval , Qu\u00e9bec, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"2","key":"2026061619574745700_dgag043-B1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2213-8587(24)00318-8","article-title":"Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment","volume":"13","author":"Stefan","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2026061619574745700_dgag043-B2","doi-asserted-by":"crossref","first-page":"100485","DOI":"10.1016\/j.jlr.2023.100485","article-title":"From NAFLD to MASLD: updated naming and diagnosis criteria for fatty liver disease","volume":"65","author":"Rinella","year":"2024","journal-title":"J Lipid Res"},{"issue":"7","key":"2026061619574745700_dgag043-B3","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"issue":"1","key":"2026061619574745700_dgag043-B4","doi-asserted-by":"crossref","first-page":"22232","DOI":"10.1038\/s41598-024-72795-0","article-title":"Global burden of metabolic dysfunction-associated steatotic liver disease attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2021","volume":"14","author":"Yang","year":"2024","journal-title":"Sci Rep"},{"issue":"11","key":"2026061619574745700_dgag043-B5","doi-asserted-by":"crossref","first-page":"100437","DOI":"10.1016\/j.xcrm.2021.100437","article-title":"Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease","volume":"2","author":"Ghodsian","year":"2021","journal-title":"Cell Rep Med"},{"issue":"3","key":"2026061619574745700_dgag043-B6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort","volume":"73","author":"Anstee","year":"2020","journal-title":"J Hepatol"},{"issue":"6","key":"2026061619574745700_dgag043-B7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41588-022-01078-z","article-title":"A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation","volume":"54","author":"Vujkovic","year":"2022","journal-title":"Nat Genet"},{"issue":"10","key":"2026061619574745700_dgag043-B8","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/s41588-023-01497-6","article-title":"Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease","volume":"55","author":"Chen","year":"2023","journal-title":"Nat Genet"},{"issue":"11","key":"2026061619574745700_dgag043-B9","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41588-022-01199-5","article-title":"Multiomics study of nonalcoholic fatty liver disease","volume":"54","author":"Sveinbjornsson","year":"2022","journal-title":"Nat Genet"},{"issue":"5","key":"2026061619574745700_dgag043-B10","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrg2344","article-title":"Genome-wide association studies for complex traits: consensus, uncertainty and challenges","volume":"9","author":"McCarthy","year":"2008","journal-title":"Nat Rev Genet"},{"issue":"6","key":"2026061619574745700_dgag043-B11","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/eurjpc\/zwab212","article-title":"Risk of cardiovascular events in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"29","author":"Alon","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"2026061619574745700_dgag043-B12","unstructured":"Gobeil \u00c9, Bourgault J, Gagnon E, et al \u00a02026. Supplementary materials for \u201cIntegrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease\u201d. Figshare. 2026. Deposited online February 10, 2026. 10.6084\/m9.figshare.31306675"},{"issue":"9","key":"2026061619574745700_dgag043-B13","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"18","key":"2026061619574745700_dgag043-B14","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1093\/bioinformatics\/btab135","article-title":"RNA-SeQC 2: efficient RNA-seq quality control and quantification for large cohorts","volume":"37","author":"Graubert","year":"2021","journal-title":"Bioinformatics"},{"issue":"3","key":"2026061619574745700_dgag043-B15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nprot.2011.457","article-title":"Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses","volume":"7","author":"Stegle","year":"2012","journal-title":"Nat Protoc"},{"issue":"1","key":"2026061619574745700_dgag043-B16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13059-019-1836-7","article-title":"Scaling computational genomics to millions of individuals with GPUs","volume":"20","author":"Taylor-Weiner","year":"2019","journal-title":"Genome Biol"},{"issue":"17","key":"2026061619574745700_dgag043-B17","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"2026061619574745700_dgag043-B18","doi-asserted-by":"crossref","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"issue":"10","key":"2026061619574745700_dgag043-B19","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41588-020-0682-6","article-title":"Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases","volume":"52","author":"Zheng","year":"2020","journal-title":"Nat Genet"},{"issue":"4","key":"2026061619574745700_dgag043-B20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng.2213","article-title":"Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits","volume":"44","author":"Yang","year":"2012","journal-title":"Nat Genet"},{"issue":"5","key":"2026061619574745700_dgag043-B21","doi-asserted-by":"crossref","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"issue":"5","key":"2026061619574745700_dgag043-B22","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","article-title":"Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification","volume":"21","author":"Yanai","year":"2005","journal-title":"Bioinformatics"},{"issue":"6235","key":"2026061619574745700_dgag043-B23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium. Human genomics","year":"2015","journal-title":"Science"},{"issue":"3","key":"2026061619574745700_dgag043-B24","doi-asserted-by":"crossref","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"7886","key":"2026061619574745700_dgag043-B25","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-021-04103-z","article-title":"Exome sequencing and analysis of 454,787 UK Biobank participants","volume":"599","author":"Backman","year":"2021","journal-title":"Nature"},{"issue":"3","key":"2026061619574745700_dgag043-B26","doi-asserted-by":"crossref","first-page":"100066","DOI":"10.1016\/j.xgen.2021.100066","article-title":"Machine learning enables new insights into genetic contributions to liver fat accumulation","volume":"1","author":"Haas","year":"2021","journal-title":"Cell Genom"},{"issue":"5","key":"2026061619574745700_dgag043-B27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41588-022-01034-x","article-title":"Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia","volume":"54","author":"Palmer","year":"2022","journal-title":"Nat Genet"},{"issue":"D1","key":"2026061619574745700_dgag043-B28","doi-asserted-by":"crossref","first-page":"D988","DOI":"10.1093\/nar\/gkab1049","article-title":"Ensembl 2022","volume":"50","author":"Cunningham","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"7809","key":"2026061619574745700_dgag043-B29","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"issue":"7","key":"2026061619574745700_dgag043-B30","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/cvr\/cvaf078","article-title":"RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study","volume":"121","author":"Gagnon","year":"2025","journal-title":"Cardiovasc Res"},{"issue":"9","key":"2026061619574745700_dgag043-B31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/eurheartj\/ehad845","article-title":"Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk","volume":"45","author":"Gobeil","year":"2024","journal-title":"Eur Heart J"},{"issue":"7982","key":"2026061619574745700_dgag043-B32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"issue":"7307","key":"2026061619574745700_dgag043-B33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"issue":"10","key":"2026061619574745700_dgag043-B34","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat Genet"},{"issue":"1","key":"2026061619574745700_dgag043-B35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s44161-021-00009-1","article-title":"A mechanistic framework for cardiometabolic and coronary artery diseases","volume":"1","author":"Koplev","year":"2022","journal-title":"Nat Cardiovasc Res"},{"issue":"4","key":"2026061619574745700_dgag043-B36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","author":"Kozlitina","year":"2014","journal-title":"Nat Genet"},{"issue":"3","key":"2026061619574745700_dgag043-B37","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/hep.31238","article-title":"Combined effect of PNPLA3, TM6SF2, and HSD17B13 variants on risk of cirrhosis and hepatocellular carcinoma in the general population","volume":"72","author":"Gellert-Kristensen","year":"2020","journal-title":"Hepatol Baltim Md"},{"issue":"3","key":"2026061619574745700_dgag043-B38","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ajhg.2021.01.012","article-title":"Genetic control of the human brain proteome","volume":"108","author":"Robins","year":"2021","journal-title":"Am J Hum Genet"},{"issue":"703","key":"2026061619574745700_dgag043-B39","doi-asserted-by":"crossref","first-page":"eabq5923","DOI":"10.1126\/scitranslmed.abq5923","article-title":"Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease","volume":"15","author":"Sung","year":"2023","journal-title":"Sci Transl Med"},{"issue":"D1","key":"2026061619574745700_dgag043-B40","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"2026061619574745700_dgag043-B41","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1042\/BST20150101","article-title":"Tribbles-1: a novel regulator of hepatic lipid metabolism in humans","volume":"43","author":"Bauer","year":"2015","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"2026061619574745700_dgag043-B42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.75","article-title":"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans","volume":"40","author":"Kathiresan","year":"2008","journal-title":"Nat Genet"},{"issue":"3","key":"2026061619574745700_dgag043-B43","doi-asserted-by":"crossref","first-page":"e000884","DOI":"10.1161\/JAHA.114.000884","article-title":"Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease","volume":"3","author":"Douvris","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"2026061619574745700_dgag043-B44","doi-asserted-by":"crossref","first-page":"e004674","DOI":"10.1161\/CIRCGEN.124.004674","article-title":"Long noncoding RNA TRIBAL links the 8q24.13 locus to hepatic lipid metabolism and coronary artery disease","volume":"17","author":"Soubeyrand","year":"2024","journal-title":"Circ Genomic Precis Med"},{"issue":"9","key":"2026061619574745700_dgag043-B45","doi-asserted-by":"crossref","first-page":"e0322975","DOI":"10.1371\/journal.pone.0322975","article-title":"Deciphering the role of the lncRNA TRIBAL in hepatocyte models","volume":"20","author":"Soubeyrand","year":"2025","journal-title":"PLoS One"},{"issue":"5","key":"2026061619574745700_dgag043-B46","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41580-023-00694-9","article-title":"Transcription regulation by long non-coding RNAs: mechanisms and disease relevance","volume":"25","author":"Ferrer","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"2026061619574745700_dgag043-B47","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.3390\/biom11111709","article-title":"Functional role of AKNA: a scoping review","volume":"11","author":"Ram\u00edrez-Gonz\u00e1lez","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"2026061619574745700_dgag043-B48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jhep.2022.02.018","article-title":"Ephrin-A3\/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma","volume":"77","author":"Husain","year":"2022","journal-title":"J Hepatol"},{"issue":"11","key":"2026061619574745700_dgag043-B49","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1158\/0008-5472.CAN-20-3134","article-title":"DNA damage response protein CHK2 regulates metabolism in liver cancer","volume":"81","author":"Lulli","year":"2021","journal-title":"Cancer Res"},{"issue":"3","key":"2026061619574745700_dgag043-B50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ymgme.2015.12.008","article-title":"Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes","volume":"117","author":"Chapman","year":"2016","journal-title":"Mol Genet Metab"},{"issue":"10","key":"2026061619574745700_dgag043-B51","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/hep4.1751","article-title":"Association of genetic risk score with NAFLD in an ethnically diverse cohort","volume":"5","author":"Wang","year":"2021","journal-title":"Hepatol Commun"},{"issue":"4","key":"2026061619574745700_dgag043-B52","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0035-1567870","article-title":"Insights from genome-wide association analyses of nonalcoholic fatty liver disease","volume":"35","author":"Kahali","year":"2015","journal-title":"Semin Liver Dis"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag043\/66735561\/dgag043.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/7\/1980\/66735561\/dgag043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/7\/1980\/66735561\/dgag043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:58:01Z","timestamp":1781654281000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/7\/1980\/8457129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,2,4]]},"published-print":{"date-parts":[[2026,6,17]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag043","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,2,4]]}}}