{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:06:21Z","timestamp":1784073981017,"version":"3.55.0"},"reference-count":15,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with potent vasoactive and metabolic effects in adipose tissue, but its effects on splanchnic blood flow (SBF) in humans remain unclear. Investigating potential regional differences is important for understanding the vascular actions of GIP in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to examine the effects of GIP on SBF, both independently and in combination with hyperglycemia and hyperinsulinemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomized, controlled crossover study, 8 healthy, lean male participants underwent 4 separate experimental conditions. The interventions included intravenous infusions of either GIP at a rate of 1.5 pmol\u22121 kg\u22121 minute\u22121 or saline, administered alone or in combination with a hyperglycemic and hyperinsulinemic clamp, respectively. Splanchnic blood flow was measured by Fick's Principle after catheterization of a hepatic vein, using indocyanine green as indicator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Splanchnic blood flow remained comparable across all experimental conditions, including GIP and saline infusions, both with and without the hyperglycemic and hyperinsulinemic clamp (P = .42).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Under the applied conditions, GIP does not appear to play a substantial role in the acute regulation of net SBF, either alone or in combination with induced hyperglycemia and hyperinsulinemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag084","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:32:04Z","timestamp":1772541124000},"page":"2315-2319","source":"Crossref","is-referenced-by-count":0,"title":["The effects of glucose-dependent insulinotropic polypeptide on net splanchnic blood flow in lean humans"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3782-8374","authenticated-orcid":false,"given":"Meena","family":"Asmar","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital , 2400 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Research, Faculty of Health Science, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"B\u00fclow","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital , 2400 Copenhagen ,","place":["Denmark"]},{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]},{"name":"NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Asmar","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital , 2400 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen University Hospital , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"2026071419573192700_dgag084-B1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0083-6729(08)00615-8","article-title":"Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; 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