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Biomarkers differing by PCOS status were further examined for interaction effects on maternal and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Monocyte chemoattractant protein-1 concentrations were 15% higher in women with PCOS compared with those without (geometric mean ratio [GMR]: 1.15; 95% CI: 1.01, 1.31; P &amp; .04), but this association was attenuated after adjustment for maternal age and body mass index (BMI). Early pregnancy FABP4 concentrations were 32% higher in women with PCOS compared with those without (GMR: 1.32; 95% CI: 1.04, 1.68; P &amp; .02), and this association remained significant after adjustment for maternal age (GMR: 1.34; 95% CI: 1.05-1.71; P &amp; .02), but was attenuated after adjustment for BMI. No other biomarkers differed by PCOS status, and MCP1 or FABP4 showed no interactions with maternal or neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Monocyte chemoattractant protein-1 and FABP4 concentrations were elevated in early pregnancy among women with PCOS, largely reflecting maternal adiposity. These markers did not modify associations between PCOS and pregnancy outcomes. Larger longitudinal studies are needed to clarify underlying inflammatory and metabolic pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag098","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:40:01Z","timestamp":1772800801000},"page":"e1961-e1972","source":"Crossref","is-referenced-by-count":2,"title":["Early pregnancy biomarkers of inflammation and metabolic regulation in polycystic ovary syndrome"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-622X","authenticated-orcid":false,"given":"Simon","family":"Alesi","sequence":"first","affiliation":[{"name":"Monash Centre for Health Research and Implementation (MCHRI), Monash University , Clayton, VIC 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taitum","family":"Mason","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation (MCHRI), 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