{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:28:46Z","timestamp":1786580926947,"version":"build-2736575974"},"reference-count":18,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK121888"],"award-info":[{"award-number":["K23DK121888"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03DK132121"],"award-info":[{"award-number":["R03DK132121"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Data on cognition in patients with primary aldosteronism (PA) are scarce. Mild autonomous cortisol secretion (MACS), defined based on post-dexamethasone cortisol &amp;gt;1.8 mcg\/dL, is diagnosed in up to 30% of patients with PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>(1) Assess cognition in patients with PA vs referent subjects with hypertension and (2) determine differences in cognition between patients with PA and those with MACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, cross-sectional study, 2019-2023. Cognition was assessed by National Institute of Health Toolbox Cognition Battery and reported as T-scores corrected for age, sex, race, and education. Only subjects with hypertension were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cognitive assessment was performed in 52 patients with PA (including 11 patients with both PA and MACS, median age of 51.0 years, 30 (57.7%) women), 47 patients with MACS (median age of 57.0 years, 31 (66.0%) women), and 52 referent subjects (median age of 66.1 years, 30 (57.7%) women). When compared to referents, and after adjusting for age, smoking, systolic blood pressure, and alcohol use, patients with PA had lower total cognition (\u03b2 = \u22125.7, P = .023), notably fluid cognition (\u03b2 = \u22126.8, P = .017), including attention and executive function (\u03b2 = \u22125.6, P = .012) and cognitive flexibility and executive function (\u03b2 = \u22128.2, P = .006). When compared to patients with MACS, patients with PA had a higher processing speed (\u03b2 = 9.0, P = .003). No differences in cognition were found between patients with PA with and without MACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with PA demonstrated lower cognition compared with referents and processing speed compared with MACS. Future studies should characterize the impact of MACS on the cognition of patients with PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag117","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T12:36:43Z","timestamp":1773491803000},"page":"e2171-e2178","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive assessment in patients with primary aldosteronism vs patients with mild autonomous cortisol secretion"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-0318","authenticated-orcid":false,"given":"Kai","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, West China Hospital of Sichuan University , Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic , Rochester, MN 55905 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