{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:28:45Z","timestamp":1786580925326,"version":"build-2736575974"},"reference-count":37,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"1033 department's own funds"},{"DOI":"10.13039\/100012141","name":"University Hospital of Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In osteogenesis imperfecta (OI), phenotypic variability and the limited predictive value of genotype\u2013phenotype correlations underscore the need for reliable predictive marker of disease severity. Periostin is a matricellular protein involved in bone formation, remodeling, and response to mechanical stress. It interacts with type I collagen and modulates osteoblast activity via Wnt\/\u03b2-catenin and TGF-\u03b2 signaling. Given its established role in other bone disorders, we hypothesized that circulating periostin may be a relevant biomarker in OI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a matched case\u2013control analysis of serum periostin levels in 61 adult patients with OI and 61 age-, sex-, and BMI-matched controls. Periostin was measured by ELISA. Associations between periostin levels and clinical variables were assessed using t-tests, Pearson correlations, and multivariable linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean periostin levels were significantly higher in OI patients than in controls (796.5 \u00b1 209 vs 713.6 \u00b1 167 pmol\/L, P = .017). Among OI patients, higher periostin level was associated with female sex (P = .01), presence of scoliosis (P = .01), and Sillence type III (P = .05). Positive correlations were observed between periostin and markers of axial skeletal severity as height\u2013wingspan discrepancy (r = 0.30, P = .023). In multivariable analysis, the number of severe fractures (defined as femur\/pelvis\/humerus\/vertebral fractures) was independently associated with higher periostin level (\u03b2 = 25.6, P = .041), while smoking was negatively associated (\u03b2 = \u2212269.8, P = .012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is the first to report the elevated circulating level of periostin in adults with OI and its association with disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag119","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T12:36:40Z","timestamp":1773491800000},"page":"2641-2648","source":"Crossref","is-referenced-by-count":1,"title":["Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-9353","authenticated-orcid":false,"given":"Alexandre","family":"Mercier-Guery","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E.Herriot, Service de Rhumatologie et Pathologie Osseuse , Lyon 69003 ,","place":["France"]},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-0948","authenticated-orcid":false,"given":"Maxime","family":"Auroux","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E.Herriot, Service de Rhumatologie et Pathologie Osseuse , Lyon 69003 ,","place":["France"]},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-5810","authenticated-orcid":false,"given":"Evelyne","family":"Gineyts","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Borel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-6697","authenticated-orcid":false,"given":"Pawel","family":"Szulc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-5316","authenticated-orcid":false,"given":"Elisabeth","family":"Sornay-Rendu","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-8214","authenticated-orcid":false,"given":"Elisabeth","family":"Fontanges","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E.Herriot, Service de Rhumatologie et Pathologie Osseuse , Lyon 69003 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-7033","authenticated-orcid":false,"given":"Martine","family":"Croset","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-2891","authenticated-orcid":false,"given":"Jean-Charles","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-6385","authenticated-orcid":false,"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E.Herriot, Service de Rhumatologie et Pathologie Osseuse , Lyon 69003 ,","place":["France"]},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033, LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders , Lyon 69008 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Supplementary data \u201cElevated periostin level in serum of adults with Osteogenesis Imperfecta is associated with disease severity\u201d. JCEM 2026 A Mercier Guery. 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