{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:28:43Z","timestamp":1786580923160,"version":"build-2736575974"},"reference-count":39,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32473B162608"],"award-info":[{"award-number":["32473B162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,13]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n The risk for disturbances in water homeostasis\u2014resulting in hypo- or hypernatremia\u2014increases with age. Age-related changes in arginine vasopressin (AVP) kinetics have been suggested, but findings are inconclusive due to challenges in quantifying AVP. Copeptin is a stable surrogate marker for AVP secretion, yet no data on age-related changes of copeptin kinetics are available.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n We investigated copeptin kinetics in healthy ageing, hypothesizing a reduced within-subject range of copeptin in older individuals.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n For this randomized controlled cross-over trial, 16 healthy older adults aged \u226560 years and 16 healthy younger adults aged 18-30 years were recruited. Participants underwent 1 copeptin stimulation test (infusion of 10 mL\/kg of 3% saline in 60 minutes) and 1 copeptin suppression test (ingestion of 20 mL\/kg tap water in 60 minutes) in randomized order. During both tests, copeptin was measured at baseline and at 15, 30, 45, 60, and 120 minutes. The primary outcome was the within-subject copeptin range in older adults compared with younger controls.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Median (interquartile range) age of older adults was 67 (64, 72) years and 26 (23, 28) years in younger controls. In both groups, 50% were female. The within-subject copeptin range in older adults was 12.6 (8.5, 18.7) pmol\/L and comparable with that of younger controls with 14.2 (8.5, 16.6) pmol\/L (P = .867). While the copeptin response to stimulation was comparable between groups (\u03b2 = +3.9 [95% CI: \u22122.9, +10.7; P = .020] pmol\u00b7h\/L for older adults), older adults exhibited a smaller decrease than younger controls during suppression (\u03b2 = + .8 [95% CI: +0.3, +1.3; P = .005] pmol\u00b7h\/L).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Copeptin kinetics are mostly preserved in healthy older adults, yet the ability to suppress copeptin after hydration is diminished. This may contribute to the higher prevalence of hyponatremia in older individuals and should be considered in future fluid intake guidelines.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/clinem\/dgag143","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:34:17Z","timestamp":1774956857000},"page":"2436-2444","source":"Crossref","is-referenced-by-count":1,"title":["Copeptin kinetics in healthy aging"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2091-8460","authenticated-orcid":false,"given":"Sven","family":"Lustenberger","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Riehle","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Blattmann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0668-5675","authenticated-orcid":false,"given":"Deborah R","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nania","family":"Sch\u00e4rer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-4685","authenticated-orcid":false,"given":"Julie","family":"Refardt","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"},{"name":"Department of Internal Medicine, Erasmus Medical Center , 3015 Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-0965","authenticated-orcid":false,"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel , 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"issue":"8","key":"2026081219563616100_dgag143-B1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/clinem\/dgad225","article-title":"Hormones and aging: an endocrine society scientific statement","volume":"108","author":"Cappola","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026081219563616100_dgag143-B2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.arr.2012.04.006","article-title":"Prevalence of hyponatremia on geriatric wards compared to other settings over four decades: a systematic review","volume":"12","author":"Mannesse","year":"2013","journal-title":"Ageing Res Rev"},{"issue":"3","key":"2026081219563616100_dgag143-B3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12030978","article-title":"Morbidity associated with chronic hyponatremia","volume":"12","author":"Decaux","year":"2023","journal-title":"J Clin Med"},{"issue":"9","key":"2026081219563616100_dgag143-B4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41574-025-01138-4","article-title":"Hyponatraemia in ageing","volume":"21","author":"Monnerat","year":"2025","journal-title":"Nat Rev Endocrinol"},{"issue":"20","key":"2026081219563616100_dgag143-B5","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14207146","article-title":"Association between hyponatremia and mortality and readmission in multimorbid older adults-a cohort study","volume":"14","author":"Netzer","year":"2025","journal-title":"J Clin Med"},{"issue":"7","key":"2026081219563616100_dgag143-B6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.34067\/KID.0000702022","article-title":"Hypernatremia in hospitalized patients: a large population-based study","volume":"3","author":"Arzhan","year":"2022","journal-title":"Kidney360"},{"issue":"2","key":"2026081219563616100_dgag143-B7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ecl.2013.02.005","article-title":"Age-associated abnormalities of water homeostasis","volume":"42","author":"Cowen","year":"2013","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"2026081219563616100_dgag143-B8","first-page":"26","article-title":"The aging kidney. Defending a delicate balance of fluid and electrolytes","volume":"55","author":"Beck","year":"2000","journal-title":"Geriatrics"},{"issue":"5","key":"2026081219563616100_dgag143-B9","first-page":"523","article-title":"Relationship between body composition changes and changes in physical function and metabolic risk factors in aging","volume":"8","author":"St-Onge","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"2026081219563616100_dgag143-B10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1532-5415.1994.tb07488.x","article-title":"Arginine vasopressin and osmolality in the elderly","volume":"42","author":"Johnson","year":"1994","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"2026081219563616100_dgag143-B11","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/clinchem\/39.9.2023a","article-title":"Change in arginine vasopressin concentrations with age","volume":"39","author":"Crawford","year":"1993","journal-title":"Clin Chem"},{"issue":"3","key":"2026081219563616100_dgag143-B12","first-page":"314","article-title":"The response of plasma arginine vasopressin to 14 h water deprivation in the elderly","volume":"105","author":"Li","year":"1984","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"2","key":"2026081219563616100_dgag143-B13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ageing\/24.2.151","article-title":"Age-associated alterations in thirst and arginine vasopressin in response to a water or sodium load","volume":"24","author":"Davies","year":"1995","journal-title":"Age Ageing"},{"issue":"1 Pt 2","key":"2026081219563616100_dgag143-B14","first-page":"R166","article-title":"Reduced osmotic thirst in healthy elderly men","volume":"261","author":"Phillips","year":"1991","journal-title":"Am J Physiol"},{"issue":"5","key":"2026081219563616100_dgag143-B15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/ageing\/22.5.332","article-title":"The association of age with plasma arginine vasopressin and plasma osmolality","volume":"22","author":"Duggan","year":"1993","journal-title":"Age Ageing"},{"key":"2026081219563616100_dgag143-B16","first-page":"S90","article-title":"Effects of aging on vasopressin secretion, water excretion, and thirst in man","volume":"21","author":"Ledingham","year":"1987","journal-title":"Kidney Int Suppl"},{"issue":"4","key":"2026081219563616100_dgag143-B17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0889-8529(18)30448-1","article-title":"Water excretion in the elderly","volume":"16","author":"Davis","year":"1987","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"suppl 1","key":"2026081219563616100_dgag143-B18","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1093\/ageing\/22.suppl_1.S26","article-title":"Disturbed fluid and electrolyte homoeostasis following dehydration in elderly people","volume":"22","author":"Phillips","year":"1993","journal-title":"Age Ageing"},{"issue":"2","key":"2026081219563616100_dgag143-B19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ageing\/22.2.114","article-title":"Water balance in elderly people: is there a deficiency of vasopressin?","volume":"22","author":"Faull","year":"1993","journal-title":"Age Ageing"},{"issue":"5","key":"2026081219563616100_dgag143-B20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/ageing\/16.5.285","article-title":"Altered water excretion in healthy elderly men","volume":"16","author":"Crowe","year":"1987","journal-title":"Age Ageing"},{"issue":"9","key":"2026081219563616100_dgag143-B21","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1172\/JCI107423","article-title":"Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma","volume":"52","author":"Robertson","year":"1973","journal-title":"J Clin Invest"},{"issue":"2_pt_2","key":"2026081219563616100_dgag143-B22","doi-asserted-by":"crossref","first-page":"I129","DOI":"10.1161\/01.HYP.5.2_Pt_2.I129","article-title":"Plasma and platelet vasopressin in essential hypertension and congestive heart failure","volume":"5","author":"Preibisz","year":"1983","journal-title":"Hypertension"},{"issue":"1","key":"2026081219563616100_dgag143-B23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","article-title":"Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin","volume":"52","author":"Morgenthaler","year":"2006","journal-title":"Clin Chem"},{"issue":"60","key":"2026081219563616100_dgag143-B24","doi-asserted-by":"crossref","DOI":"10.21105\/joss.03118","article-title":"\u2018Presize\u2019: an R-package for precision-based sample size calculation in clinical research","volume":"6","author":"Haynes","year":"2021","journal-title":"J Open Source Softw"},{"key":"2026081219563616100_dgag143-B25","author":"Lustenberger"},{"issue":"6","key":"2026081219563616100_dgag143-B26","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1046\/j.1532-5415.2001.49157.x","article-title":"Chronic idiopathic hyponatremia in older people due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) possibly related to aging","volume":"49","author":"Anpalahan","year":"2001","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"2026081219563616100_dgag143-B27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1681\/ASN.0000000588","article-title":"Syndrome of inappropriate antidiuresis","volume":"36","author":"Rosner","year":"2025","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"2026081219563616100_dgag143-B28","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.clnu.2022.01.024","article-title":"ESPEN practical guideline: clinical nutrition and hydration in geriatrics","volume":"41","author":"Volkert","year":"2022","journal-title":"Clin Nutr"},{"issue":"4","key":"2026081219563616100_dgag143-B29","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1152\/jappl.2001.91.4.1893","article-title":"Sex differences in osmotic regulation of AVP and renal sodium handling","volume":"91","author":"Stachenfeld","year":"2001","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"2026081219563616100_dgag143-B30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/JES.0b013e31817be928","article-title":"Sex hormone effects on body fluid regulation","volume":"36","author":"Stachenfeld","year":"2008","journal-title":"Exerc Sport Sci Rev"},{"issue":"5","key":"2026081219563616100_dgag143-B31","doi-asserted-by":"crossref","first-page":"F1116","DOI":"10.1152\/ajprenal.00741.2010","article-title":"Gender difference in antidiuretic response to desmopressin","volume":"300","author":"Juul","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"2026081219563616100_dgag143-B32","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/gerona\/gls128","article-title":"Urine concentrating and diluting ability during aging","volume":"67","author":"Sands","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"2026081219563616100_dgag143-B33","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s11357-024-01245-6","article-title":"Body composition and aging: cross-sectional results from the INSPIRE study in people 20 to 93 years old","volume":"47","author":"Briand","year":"2025","journal-title":"Geroscience"},{"issue":"4","key":"2026081219563616100_dgag143-B34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1532-5415.1985.tb07117.x","article-title":"Longitudinal studies on the rate of decline in renal function with age","volume":"33","author":"Lindeman","year":"1985","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"2026081219563616100_dgag143-B35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ajcn\/82.1.49","article-title":"Bioelectrical impedance analysis: population reference values for phase angle by age and sex","volume":"82","author":"Barbosa-Silva","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"2026081219563616100_dgag143-B36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.ejcn.1601198","article-title":"Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years","volume":"55","author":"Kyle","year":"2001","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"2026081219563616100_dgag143-B37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1186\/s12889-022-13280-z","article-title":"Associations between hydration status, body composition, sociodemographic and lifestyle factors in the general population: a cross-sectional study","volume":"22","author":"Ekingen","year":"2022","journal-title":"BMC Public Health"},{"key":"2026081219563616100_dgag143-B38","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2147\/CIA.S277171","article-title":"Assessment of age-induced changes in body fat percentage and BMI aided by Bayesian modelling: a cross-sectional cohort study in middle-aged and older adults","volume":"15","author":"Macek","year":"2020","journal-title":"Clin Interv Aging"},{"issue":"6","key":"2026081219563616100_dgag143-B39","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/gerona\/glac233","article-title":"Body composition in late midlife as a predictor of accelerated age-associated deficit-accumulation from late midlife into old age: a longitudinal birth cohort study","volume":"78","author":"Haapanen","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag143\/67989318\/dgag143.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/9\/2436\/67989318\/dgag143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/9\/2436\/67989318\/dgag143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:56:47Z","timestamp":1786579007000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/9\/2436\/8643935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,4,9]]},"published-print":{"date-parts":[[2026,8,13]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag143","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,4,9]]}}}