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Analyses were additionally stratified by baseline TSH levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 286 included participants (48% women; median age 75 [70, 82] years; median baseline TSH 6.44 [5.36, 7.81] mIU\/L), 142 were randomized to levothyroxine. Overall, levothyroxine showed no effects on ApoB (\u22120.03 [95% CI: \u22120.07, 0.00] g\/L), Total-C (\u22120.17 [\u22120.34, 0.00] mmol\/L), non-HDL-C (\u22120.15 [\u22120.31, 0.00] mmol\/L), RC (\u22120.09 [\u22120.16, \u22120.01] mmol\/L), LDL-C (\u22120.07 [\u22120.15, 0.02] mmol\/L), and TG (\u22120.07 [\u22120.15, 0.01] mmol\/L). In participants with baseline TSH \u226510 mIU\/L (n = 27), potentially beneficial changes (P &amp;lt; .05, but not significant after multiple-testing correction) were observed for all clinically relevant lipids except HDL-C, as well as for ApoB-containing lipoproteins, VLDL size, and fatty acids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In older adults with subclinical hypothyroidism, levothyroxine treatment showed no effects on cardiometabolic biomarkers, although potentially favorable changes in lipids and lipoproteins were observed for individuals with baseline TSH \u226510 mIU\/L.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag155","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:36:08Z","timestamp":1775561768000},"page":"2445-2455","source":"Crossref","is-referenced-by-count":3,"title":["Levothyroxine treatment response of cardiometabolic biomarkers in older adults with subclinical hypothyroidism"],"prefix":"10.1210","volume":"111","author":[{"given":"Linjun","family":"Ao","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Leiden University Medical Center , 2300 RC Leiden ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-809X","authenticated-orcid":false,"given":"Raymond","family":"Noordam","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center , 2300 RC Leiden ,","place":["the Netherlands"]},{"name":"Department of Public Health and Primary Care\/LUMC Campus The Hague, Leiden University Medical Center , 2333 RC Leiden ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-0528","authenticated-orcid":false,"given":"Stella","family":"Trompet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center , 2300 RC Leiden ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolien A","family":"van Vliet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center , 2300 RC Leiden ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-2593","authenticated-orcid":false,"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow , Glasgow G12 8TA ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rodondi","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , 3012 Bern ,","place":["Switzerland"]},{"name":"Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern , 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Moutzouri","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , 3012 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Atighetchi","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , 3012 Bern ,","place":["Switzerland"]},{"name":"Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern , 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M","family":"Kearney","sequence":"additional","affiliation":[{"name":"School of Public Health, University College Cork , Pw31584 Cork ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Quinn","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow , Glasgow G12 8TA ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , 2300 RC Leiden ,","place":["the Netherlands"]},{"name":"Netherlands Heart Institute , 3501 DG Utrecht ,","place":["the 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