{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:05:22Z","timestamp":1789517122293,"version":"build-2803163510"},"reference-count":55,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Biblioth\u00e8que Scientifique de l\u2019Internat de Lyon and the Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acromegaly results from different histological subtypes of pituitary adenomas, mainly pure GH-secreting adenomas (densely or sparsely granulated) and GH-PRL adenomas. Data on the impact of histological subtype on surgical outcomes in acromegaly remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the impact of pituitary adenoma histological subtype on acromegaly remission at 3 months and last follow-up, as well as on disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, single-center study of 128 patients who underwent surgery for GH or GH-PRL adenomas, without prior medical therapy, between 2012 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the adenomas, 61% were pure GH (39% DG, 22% SG) and 39% were GH-PRL. Compared with DG adenomas, SG adenomas were diagnosed at a younger age (P = .006), were larger (P = .022), expressed more SST5 (P = .032) and less SST2 (P &amp;lt; .001). GH-PRL adenomas were more frequently p53-positive (P = .024), had a higher mitotic count (P = .017) than DG adenomas and expressed more SST2 than SG adenomas (P &amp;lt; .001). The remission rates for DG, GH-PRL and SG adenomas were not significantly different at 3 months (60%, 58% and 43%, P = .337), or at last follow-up (80%, 74% and 57%, P = .091), nor was disease control at last follow-up (94%, 96% and 82%, P = .115) after 42 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Histological subtype was not significantly associated with remission or control of acromegaly. Although a trend toward lower remission rates was observed in SG adenomas, its clinical impact appears limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag174","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T11:40:43Z","timestamp":1776598843000},"page":"2850-2860","source":"Crossref","is-referenced-by-count":1,"title":["Impact of pituitary adenoma histological subtype on remission and disease control in acromegaly"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0455-2051","authenticated-orcid":false,"given":"Alexandra","family":"Monnot","sequence":"first","affiliation":[{"name":"Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon , Bron 69677 ,","place":["France"]},{"name":"Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-7258","authenticated-orcid":false,"given":"Mirela-Diana","family":"Ilie","sequence":"additional","affiliation":[{"name":"Endocrinology Department, C.I. Parhon National Institute of Endocrinology , Bucharest 011863 ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8182-5955","authenticated-orcid":false,"given":"Camille","family":"Sergeant","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon , Bron 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-0317","authenticated-orcid":false,"given":"Alexandre","family":"Vasiljevic","sequence":"additional","affiliation":[{"name":"Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon , Lyon 69008 ,","place":["France"]},{"name":"Pathology Department, Reference Center for Rare Pituitary Diseases HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon , Bron 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihem","family":"Zaghdoud","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon , Bron 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-3430","authenticated-orcid":false,"given":"Emmanuel","family":"Jouanneau","sequence":"additional","affiliation":[{"name":"Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon , Lyon 69008 ,","place":["France"]},{"name":"Neurosurgery Department, Reference Center for Rare Pituitary Diseases HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon , Bron 69677 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9517-338X","authenticated-orcid":false,"given":"G\u00e9rald","family":"Raverot","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon , Bron 69677 ,","place":["France"]},{"name":"Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon , Lyon 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"11","key":"2026091519581826200_dgag174-B1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2026091519581826200_dgag174-B2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","article-title":"Acromegaly","volume":"5","author":"Colao","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"2026091519581826200_dgag174-B3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.beem.2009.05.010","article-title":"Pituitary tumours: acromegaly","volume":"23","author":"Chanson","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026091519581826200_dgag174-B4","volume-title":"Central Nervous System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2021","edition":"5th ed"},{"key":"2026091519581826200_dgag174-B5","volume-title":"Endocrine and Neuroendocrine Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2025","edition":"5th ed"},{"issue":"8","key":"2026091519581826200_dgag174-B6","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-23-0021","article-title":"The world health organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal","volume":"30","author":"Villa","year":"2023","journal-title":"Endocr Relat Cancer"},{"issue":"4","key":"2026091519581826200_dgag174-B7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11154-020-09588-z","article-title":"Multidisciplinary management of acromegaly: a consensus","volume":"21","author":"Giustina","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"issue":"11","key":"2026091519581826200_dgag174-B8","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/jc.2014-2700","article-title":"Acromegaly: an endocrine society clinical practice guideline","volume":"99","author":"Katznelson","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026091519581826200_dgag174-B9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11102-023-01360-1","article-title":"Consensus on criteria for acromegaly diagnosis and remission","volume":"27","author":"Giustina","year":"2024","journal-title":"Pituitary"},{"issue":"6","key":"2026091519581826200_dgag174-B10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00428-019-02655-0","article-title":"A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European pituitary pathology group (EPPG) proposal","volume":"475","author":"Villa","year":"2019","journal-title":"Virchows Arch"},{"issue":"24","key":"2026091519581826200_dgag174-B11","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N Engl J Med"},{"issue":"2","key":"2026091519581826200_dgag174-B12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12022-008-9029-z","article-title":"Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form","volume":"19","author":"Obari","year":"2008","journal-title":"Endocr Pathol"},{"issue":"1","key":"2026091519581826200_dgag174-B13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-2265.2011.04163.x","article-title":"Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly","volume":"76","author":"Fougner","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2026091519581826200_dgag174-B14","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s11102-020-01063-x","article-title":"Prognostic factors of biochemical remission after transsphenoidal surgery for acromegaly: a structured review","volume":"23","author":"Agrawal","year":"2020","journal-title":"Pituitary"},{"key":"2026091519581826200_dgag174-B15","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.957301","article-title":"Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly","volume":"13","author":"Tomasik","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2026091519581826200_dgag174-B16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12020-014-0383-y","article-title":"Growth hormone tumor histological subtypes predict response to surgical and medical therapy","volume":"49","author":"Kiseljak-Vassiliades","year":"2015","journal-title":"Endocrine"},{"issue":"1","key":"2026091519581826200_dgag174-B17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-0033-1354578","article-title":"Factors associated with biochemical remission after microscopic transsphenoidal surgery for acromegaly","volume":"75","author":"Sun","year":"2014","journal-title":"J Neurol Surg B Skull Base"},{"issue":"3","key":"2026091519581826200_dgag174-B18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s12020-018-1590-8","article-title":"Predictors of surgical outcome and early criteria of remission in acromegaly","volume":"60","author":"Antunes","year":"2018","journal-title":"Endocrine"},{"issue":"2","key":"2026091519581826200_dgag174-B19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/neuros\/nyx020","article-title":"Long-term endocrine outcomes following endoscopic endonasal transsphenoidal surgery for acromegaly and associated prognostic factors","volume":"81","author":"Babu","year":"2017","journal-title":"Neurosurgery"},{"issue":"12","key":"2026091519581826200_dgag174-B20","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1007\/s00701-014-2230-6","article-title":"An analysis of granulation patterns, MIB-1 proliferation indices and p53 expression in 101 patients with acromegaly","volume":"156","author":"Sarkar","year":"2014","journal-title":"Acta Neurochir (Wien)"},{"issue":"3","key":"2026091519581826200_dgag174-B21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3171\/2021.11.JNS212137","article-title":"Determinants of immediate and long-term remission after initial transsphenoidal surgery for acromegaly and outcome patterns during follow-up: a longitudinal study on 659 patients","volume":"137","author":"Guo","year":"2022","journal-title":"J Neurosurg"},{"issue":"12","key":"2026091519581826200_dgag174-B22","doi-asserted-by":"crossref","first-page":"e2178","DOI":"10.1210\/clinem\/dgae126","article-title":"Differences between GH- and PRL-cosecreting and GH-secreting pituitary adenomas: a series of 604 cases","volume":"109","author":"Araujo-Castro","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"2026091519581826200_dgag174-B23","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1571598","article-title":"Comparison of the clinical and prognostic characteristics of patients with different pathological types in acromegaly","volume":"16","author":"Chong","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"2026091519581826200_dgag174-B24","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1210\/jcem.86.9.7819","article-title":"Surgical management of GH-secreting pituitary adenomas: an outcome study using modern remission criteria","volume":"86","author":"Kreutzer","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026091519581826200_dgag174-B25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-2002-23197","article-title":"A retrospective hormonal and immunohistochemical evaluation of 47 acromegalic patients: prognostic value of preoperative plasma prolactin","volume":"34","author":"De Marinis","year":"2002","journal-title":"Horm Metab Res"},{"issue":"1","key":"2026091519581826200_dgag174-B26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3171\/2018.4.JNS18230","article-title":"Growth hormone and prolactin-staining tumors causing acromegaly: a retrospective review of clinical presentations and surgical outcomes","volume":"131","author":"Rick","year":"2019","journal-title":"J Neurosurg"},{"issue":"1","key":"2026091519581826200_dgag174-B27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12902-021-00850-2","article-title":"Association of different pathologic subtypes of growth hormone producing pituitary adenoma and remission in acromegaly patients: a retrospective cohort study","volume":"21","author":"Dehghani","year":"2021","journal-title":"BMC Endocr Disord"},{"issue":"6","key":"2026091519581826200_dgag174-B28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s11102-020-01075-7","article-title":"Cystic appearance on magnetic resonance imaging in bihormonal growth hormone and prolactin tumors in acromegaly","volume":"23","author":"Varlamov","year":"2020","journal-title":"Pituitary"},{"issue":"4","key":"2026091519581826200_dgag174-B29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3171\/2014.12.JNS141083","article-title":"Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification","volume":"122","author":"Micko","year":"2015","journal-title":"J Neurosurg"},{"issue":"4","key":"2026091519581826200_dgag174-B30","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/EJE-10-0586","article-title":"Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae","volume":"163","author":"Bakhtiar","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2026091519581826200_dgag174-B31","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11102-012-0445-1","article-title":"Growth hormone granulation pattern and somatostatin receptor subtype 2A correlate with postoperative somatostatin receptor ligand response in acromegaly: a large single center experience","volume":"16","author":"Brzana","year":"2013","journal-title":"Pituitary"},{"issue":"11","key":"2026091519581826200_dgag174-B32","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1210\/clinem\/dgac512","article-title":"Predictive factors of somatostatin receptor ligand response in acromegaly-A prospective study","volume":"107","author":"Ilie","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026091519581826200_dgag174-B33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00401-013-1084-y","article-title":"A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up","volume":"126","author":"Trouillas","year":"2013","journal-title":"Acta Neuropathol"},{"key":"2026091519581826200_dgag174-B34","doi-asserted-by":"crossref","unstructured":"Monnot A, Ilie MD, Sergeant C, et al \u00a0Data from: Impact of pituitary adenoma histological subtype on remission and disease control in acromegaly. Zenodo. 2026. Deposited April 25, 2026. 10.5281\/zenodo.19766486","DOI":"10.1210\/clinem\/dgag174"},{"issue":"2","key":"2026091519581826200_dgag174-B35","doi-asserted-by":"crossref","first-page":"101264","DOI":"10.1016\/j.beem.2019.02.001","article-title":"National acromegaly registries","volume":"33","author":"Maione","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"5","key":"2026091519581826200_dgag174-B36","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/EJE-19-1023","article-title":"Management of endocrine disease: does gender matter in the management of acromegaly?","volume":"182","author":"Lenders","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026091519581826200_dgag174-B37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11102-016-0754-x","article-title":"Epidemiology of acromegaly: review of population studies","volume":"20","author":"Lavrentaki","year":"2017","journal-title":"Pituitary"},{"issue":"3","key":"2026091519581826200_dgag174-B38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1530\/EJE-21-0729","article-title":"Long-term outcomes of patients with acromegaly: a report from the Swedish pituitary register","volume":"186","author":"Arnard\u00f3ttir","year":"2022","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2026091519581826200_dgag174-B39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1530\/ERC-17-0253","article-title":"Acromegaly at diagnosis in 3173 patients from the li\u00e8ge acromegaly survey (LAS) database","volume":"24","author":"Petrossians","year":"2017","journal-title":"Endocr Relat Cancer"},{"issue":"11","key":"2026091519581826200_dgag174-B40","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s00701-016-2903-4","article-title":"Surgical treatment of acromegaly according to the 2010 remission criteria: systematic review and meta-analysis","volume":"158","author":"Starnoni","year":"2016","journal-title":"Acta Neurochir (Wien)"},{"issue":"2","key":"2026091519581826200_dgag174-B41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2265.2012.04492.x","article-title":"Outcome of multimodal therapy in operated acromegalic patients, a study in 115 patients","volume":"78","author":"Albarel","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"2026091519581826200_dgag174-B42","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s00701-014-2098-5","article-title":"Transsphenoidal surgery for acromegaly: predicting remission with early postoperative growth hormone assays","volume":"156","author":"Sarkar","year":"2014","journal-title":"Acta Neurochir (Wien)"},{"issue":"4","key":"2026091519581826200_dgag174-B43","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2010.7.FOCUS10173","article-title":"Endoscopic endonasal transsphenoidal surgery for growth hormone-secreting pituitary adenomas","volume":"29","author":"Hofstetter","year":"2010","journal-title":"Neurosurg Focus"},{"issue":"3","key":"2026091519581826200_dgag174-B44","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3171\/2014.3.JNS132214","article-title":"Aggressive transsphenoidal resection of tumors invading the cavernous sinus in patients with acromegaly: predictive factors, strategies, and outcomes","volume":"121","author":"Nishioka","year":"2014","journal-title":"J Neurosurg"},{"key":"2026091519581826200_dgag174-B45","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.743052","article-title":"Postoperative GH and degree of reduction in IGF-1 predicts postoperative hormonal remission in acromegaly","volume":"12","author":"Cardinal","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2026091519581826200_dgag174-B46","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1210\/clinem\/dgab069","article-title":"Predictors for remission after transsphenoidal surgery in acromegaly: a Dutch multicenter study","volume":"106","author":"Coopmans","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026091519581826200_dgag174-B47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12020-019-02029-1","article-title":"Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up","volume":"66","author":"Lv","year":"2019","journal-title":"Endocrine"},{"issue":"2","key":"2026091519581826200_dgag174-B48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11060-020-03669-4","article-title":"Predictors of postoperative biochemical remission in acromegaly","volume":"151","author":"Yao","year":"2021","journal-title":"J Neurooncol"},{"issue":"4","key":"2026091519581826200_dgag174-B49","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1530\/EJE-12-0864","article-title":"Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatin-naive patients with somatotroph adenomas","volume":"168","author":"Larkin","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2026091519581826200_dgag174-B50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1507\/endocrj.EJ11-0177","article-title":"Differential expression of genes related to drug responsiveness between sparsely and densely granulated somatotroph adenomas","volume":"59","author":"Kato","year":"2012","journal-title":"Endocr J"},{"issue":"2","key":"2026091519581826200_dgag174-B51","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11102-020-01096-2","article-title":"Clinical, biological, radiological, and pathological comparison of sparsely and densely granulated somatotroph adenomas: a single center experience from a cohort of 131 patients with acromegaly","volume":"24","author":"Swanson","year":"2021","journal-title":"Pituitary"},{"issue":"1","key":"2026091519581826200_dgag174-B52","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.humpath.2013.08.007","article-title":"Expression of somatostatin receptors, SSTR2A and SSTR5, in 108 endocrine pituitary tumors using immunohistochemical detection with new specific monoclonal antibodies","volume":"45","author":"Chinezu","year":"2014","journal-title":"Hum Pathol"},{"issue":"1","key":"2026091519581826200_dgag174-B53","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00401-024-02686-1","article-title":"Pituitary neuroendocrine tumors with PIT1\/SF1 co-expression show distinct clinicopathological and molecular features","volume":"147","author":"Dottermusch","year":"2024","journal-title":"Acta Neuropathol"},{"issue":"1","key":"2026091519581826200_dgag174-B54","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1210\/clinem\/dgae444","article-title":"Personalized medicine in acromegaly: the ACROFAST study","volume":"110","author":"Marques-Pamies","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2026091519581826200_dgag174-B55","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41574-025-01148-2","article-title":"Consensus on acromegaly therapeutic outcomes: an update","volume":"21","author":"Melmed","year":"2025","journal-title":"Nat Rev Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag174\/68173276\/dgag174.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/10\/2850\/68173276\/dgag174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/10\/2850\/68173276\/dgag174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:58:31Z","timestamp":1789516711000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/10\/2850\/8659428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":55,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,4,21]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag174","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,4,21]]}}}