{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:05:22Z","timestamp":1789517122526,"version":"build-2803163510"},"reference-count":59,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","award":["2012_A103"],"award-info":[{"award-number":["2012_A103"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","award":["2015_A228"],"award-info":[{"award-number":["2015_A228"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG, German Research Foundation","doi-asserted-by":"publisher","award":["413635475"],"award-info":[{"award-number":["413635475"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG, German Research Foundation","doi-asserted-by":"publisher","award":["314061271-TRR 205"],"award-info":[{"award-number":["314061271-TRR 205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007952","name":"Eva Luise und Horst K\u00f6hler Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Cushing\u2019s syndrome (CS) is associated with an unfavorable lipid profile. However, data on lipid alterations during early postoperative remission, a particularly cardiovascular vulnerable period, are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluation of lipid profiles during active CS and the early postoperative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>In this single-center cohort study at LMU Hospital, Munich, we analyzed lipid profiles (total cholesterol, LDL, HDL, ApoA1, ApoB, lipoprotein (a), triglycerides, and non-esterified fatty acids) and metabolic markers in 26 patients with endogenous CS before surgery and 1, 3, 6, 12 and 24 months (n = 23) after curative surgery and compared them with 26 age-, BMI-, and sex-matched controls without hypercortisolism at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Paradoxically, most lipid parameters worsened postoperatively. One month following surgery, HDL (1 month postoperative 38 mg\/dL [35-46] vs. active CS 49.5 mg\/dL [45-61.3], P &amp;lt; .0001) and ApoA1 concentrations (1-month postoperative 160 mg\/dL [147-168] vs. active CS 193 mg\/dL [169-211], P &amp;lt; .0001) were significantly lower compared to preoperative levels. Similarly, 1-month following surgery triglycerides concentrations (1-month postoperative 185 mg\/dL [154-218] vs. active CS 129 mg\/dL [89.3-186] preoperatively, P &amp;lt; .0001) were higher. These changes remained evident until 6 months post-surgery. The triglyceride-glucose index increased during early remission and showed a positive correlation with inflammatory markers CRP and IL-6. Non-esterified fatty acids displayed 3 distinct postoperative trajectories depending on BMI at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During the early remission phase following curative surgery for CS, we observed a further deterioration in lipid parameters. This can affect cardiovascular health and provide the basis for targeted therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag178","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:52:39Z","timestamp":1776858759000},"page":"2816-2826","source":"Crossref","is-referenced-by-count":2,"title":["Deterioration of blood lipids during early postoperative remission of Cushing's syndrome: a longitudinal cohort study"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6623-2900","authenticated-orcid":false,"given":"Moritz","family":"Schrenk","sequence":"first","affiliation":[{"name":"Department of Medicine IV, LMU University Hospital, LMU Munich , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haenelt","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, LMU University Hospital, LMU Munich , 80336 Munich 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Stifel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center , 89070 Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-0296","authenticated-orcid":false,"given":"Katharina","family":"Schilbach","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, LMU University Hospital, LMU Munich , 80336 Munich ,","place":["Germany"]},{"name":"Faculty of Applied Healthcare Sciences, Deggendorf Institute of Technology , 94469 Deggendorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-6668","authenticated-orcid":false,"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, LMU University 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