{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:06:20Z","timestamp":1784073980858,"version":"3.55.0"},"reference-count":79,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Low circulating testosterone in physically stressed populations is frequently interpreted as evidence of hypogonadism or intrinsic gonadal dysfunction. However, convergent data from military field studies, endurance athletes, and competitive stress models demonstrate that testosterone suppression during sustained stress is commonly a centrally mediated, reversible adaptation rather than intrinsic testicular failure. Severe energy deficit, sleep disruption, and uncontrollable psychogenic stress suppress hypothalamic gonadotropin-releasing hormone and luteinizing hormone pulsatility, reduce testicular androgen production, and frequently increase sex hormone\u2013binding globulin (SHBG), thereby disproportionately lowering free testosterone. Human chorionic gonadotropin stimulation studies confirm preserved Leydig cell responsiveness under these conditions, supporting hypothalamic\u2013pituitary inhibition as the dominant mechanism. In contrast, high mechanical loading in resistance-trained men does not suppress basal testosterone when energy availability is maintained, underscoring energetic sufficiency, not exercise modality, as the principal determinant of androgen tone. Acute competitive stress produces rapid, appraisal-dependent modulation of testosterone independent of SHBG, further demonstrating central regulation. Across contexts, androgen suppression tracks energetic and psychological constraint and is reversible with restoration of energy balance and recovery. Recognition of this adaptive endocrine phenotype is essential to distinguish functional central suppression from pathological hypogonadism and guide appropriate clinical evaluation.<\/jats:p>","DOI":"10.1210\/clinem\/dgag181","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:44:00Z","timestamp":1777031040000},"page":"e1951-e1960","source":"Crossref","is-referenced-by-count":2,"title":["Stress-associated testosterone suppression: central adaptation or hypogonadism?"],"prefix":"10.1210","volume":"111","author":[{"given":"Karl E","family":"Friedl","sequence":"first","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine , Natick, MA 01760-5007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley C","family":"Nindl","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Laboratory, University of Pittsburgh , Pittsburgh, PA 15203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-8353","authenticated-orcid":false,"given":"Adam W","family":"Potter","sequence":"additional","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine , Natick, MA 01760-5007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"3","key":"2026071419570923400_dgag181-B1","first-page":"231","article-title":"The hypothalamo-pituitary regulation of androgen secretion in young men after prolonged physical stress combined with energy and sleep deprivation","volume":"127","author":"Opstad","year":"1992","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"5","key":"2026071419570923400_dgag181-B2","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1152\/jappl.2000.88.5.1820","article-title":"Endocrine markers of semistarvation in healthy lean men in a multistressor 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