{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:49:31Z","timestamp":1791924571303,"version":"4.3.4"},"reference-count":41,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01AG080516"],"award-info":[{"award-number":["1R01AG080516"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01DK106618"],"award-info":[{"award-number":["R01DK106618"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institutes on Aging","doi-asserted-by":"publisher","award":["R01HL174676"],"award-info":[{"award-number":["R01HL174676"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute Diabetes and Digestive and Kidney Disease","doi-asserted-by":"publisher","award":["2023\/00196-4"],"award-info":[{"award-number":["2023\/00196-4"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Adrenal vein sampling is the standard of care for guiding surgery in primary aldosteronism (PA). Because of its technical complexity and limited availability, however, many centers still use cross-sectional imaging for surgical guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Single referral-center retrospective cohort study of patients with PA who underwent unilateral adrenalectomy between 2012 and 2024. Blinded cross-sectional imaging interpretation was corroborated with aldosterone synthase (CYP11B2) immunohistochemistry (IHC) of formalin-fixed paraffin-embedded adrenal tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 173 patients, age 52.6 \u00b1 11.8 years, 119 (68.8%) were men, 134 (77.5%) White, 30 (17.3%) Black, and 9 (5.2%) other races. CYP11B2 IHC identified a single aldosterone-producing adenoma (APA) or nodule (APN) in 87 (50.3%) and 38 (22.0%) patients, respectively; multiple CYP11B2-positive foci in 45 (26.0%) patients, and no CYP11B2-positive lesions in 3 patients. A single corresponding APA or APN on both IHC and imaging was found in only 53\/173 (31%) patients, and an additional 38\/173 (22%) patients also had adrenal thickening. Discrepant IHC-imaging findings were observed in 82 (47.4%) patients, including (1) additional nodule(s) on imaging (ipsilateral nonfunctional adenoma [n = 21], bilateral nodules [n = 29], or contralateral nodule(s) [n = 6]); (2) normal adrenals (n = 2) or unilateral adrenal hyperplasia (n = 4), but discrete CYP11B2-positive foci on IHC; and (3) corresponding APA\/APN on imaging-IHC with additional CYP11B2-positive area(s) (n = 20). Patients with IHC-imaging concordance had the highest proportion of women and KCNJ5 mutations, while CACNA1D mutations were most frequent in the discordant group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even in patients with lateralized PA, IHC mapping of aldosterone sources corresponded with imaging findings in approximately half of the cases. These data caution against targeted therapy guided by cross-sectional imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag194","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:43:27Z","timestamp":1778060607000},"page":"2766-2773","source":"Crossref","is-referenced-by-count":2,"title":["Aldosterone synthase expression vs cross-sectional imaging in lateralized primary aldosteronism"],"prefix":"10.1210","volume":"111","author":[{"given":"Livia M","family":"Mermejo","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Diabetes, University of Michigan , Ann Arbor, MI 48109 , USA"},{"name":"Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo , Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueting","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and 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