{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:45:49Z","timestamp":1792111549570,"version":"4.4.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007505","name":"The Kirsten and Freddy Johansen\u2019s Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"The Danish Medical Research Council","doi-asserted-by":"publisher","award":["271-05-0337"],"award-info":[{"award-number":["271-05-0337"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Research Fund of Rigshospitalet, Copenhagen, Denmark"},{"DOI":"10.13039\/501100003554","name":"The Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013826","name":"Candy\u2019s Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Epiphyseal growth plate development is stimulated by GH and IGF-I. Serum IGF-I is applied as an efficacy and safety marker, monitoring growth in short GH-treated children. However, IGF-I offers poor guidance to clinicians, especially in children without growth hormone deficiency. Thus, novel biomarkers reflecting endogenous and GH-induced linear growth are needed. We evaluated the association between linear growth during pubertal transition and circulating levels of procollagen type I and II (PRO-C1 and PRO-C2, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 1700 serum samples from 213 healthy children and adolescents (51% female), ages 5-16 years, from the prospective longitudinal Copenhagen Puberty Study, followed between 2006 and 2014. We assessed peak height velocity (PHV), pubertal development, serum IGF-I, sex steroids (LC-MS\/MS), and PRO-C1 and PRO-C2 (immunoassays). Additionally, PRO-C1 and PRO-C2 were determined in short children born small for gestational age before and after 12 months of GH treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age-, sex-, and puberty-related reference intervals for PRO-C1 and PRO-C2 concentrations were established. PRO-C1 and PRO-C2 increased significantly with age and pubertal development (Tanner breast stage 1-3, P &amp;lt; .0001; Tanner genital stage 1-4, P &amp;lt; .001). During growth spurt, PRO-C1 and PRO-C2 were associated with increased height SD score (SDS) and height velocity, both reached peak concentrations at the time of PHV, earlier than IGF-I and sex-steroids, followed by a rapid decline. In GH-treated prepubertal children, PRO-C1 increased from 0.70 to 3.78 SDS (P &amp;lt; .0001) and PRO-C2 from \u22122.07 to 0.69 SDS (P = .0055).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We present longitudinal changes in PRO-C1 and PRO-C2 in normal and disordered growth, suggesting PRO-C1 and PRO-C2 as potential biomarkers of endogenous and GH-induced linear growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag203","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:37:19Z","timestamp":1778585839000},"page":"3250-3261","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal circulating procollagen-markers PRO-C1 and PRO-C2 reflect pubertal growth spurt in healthy adolescents"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-9116","authenticated-orcid":false,"given":"Li","family":"Juel Mortensen","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Nordic Bioscience, Biomarkers and Research , Herlev 2730 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3800-4253","authenticated-orcid":false,"given":"Martin","family":"Blomberg Jensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Division of Translational Endocrinology, Copenhagen University Hospital\u2014Herlev and Gentofte , 2730 Herlev ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-7443","authenticated-orcid":false,"given":"J\u00f8rgen Holm","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]},{"name":"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]},{"name":"Section of Biostatistics, Institute of Public 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