{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:44:43Z","timestamp":1792111483913,"version":"4.4.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Sanjad\u2013Sakati syndrome (SSS), also known as hypoparathyroidism\u2013intellectual disability\u2013dysmorphism syndrome, is a rare autosomal recessive disorder caused by a TBCE founder mutation. The full disease spectrum remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To comprehensively analyze growth, phenotype, endocrine manifestations, and mortality in a large multicenter SSS cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and genetic data were collected from 135 individuals across centers in the Gulf region using a REDCap survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age at inclusion was 9.1 years (range: birth\u221230 years; 50.3% female). The homozygous TBCE founder mutation (c.155_166del; p.Ser52_Gly55del) was detected in all genetically tested individuals (n = 68). Intrauterine growth restriction (mean birth weight \u22123.0 SD, length \u22123.3 SD) and dysmorphic features were universal. Postnatal growth showed severe failure to thrive during infancy, followed by persistently low height z-scores (\u22127 to \u22128). Endocrine features included hypoparathyroidism in all patients, primary hypothyroidism (16.5%), hypoglycemia (27.8%), nonautoimmune insulin-dependent diabetes (1.6%) and pituitary hormone deficiencies. Other findings included developmental delay (100%), hypocalcemic seizures (64.2%), tetany (53.3%), nephrocalcinosis (62.1%), gastroesophageal reflux (29.1%), and recurrent respiratory (63.7%) and bacterial infections (53.8%). Antibiotic prophylaxis was used in 35% of patients. Kaplan\u2013Meier analysis estimated a median survival of 27.2 years, with respiratory failure causing 84% of deaths (21\/25). The estimated overall survival at an age of 18 years was 62.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This largest reported SSS cohort highlights the high prevalence of associated endocrine, respiratory, and gastrointestinal manifestations, with respiratory failure as the leading cause of death. These data support the need for multidisciplinary care guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag226","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:48:37Z","timestamp":1781092117000},"page":"3075-3084","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive analysis of disease spectrum and mortality in Sanjad\u2013Sakati syndrome: an international rare disease registry study"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-4646","authenticated-orcid":false,"given":"Angham","family":"Almutair","sequence":"first","affiliation":[{"name":"Endocrinology Division, Department of Pediatrics, King Abdullah Specialized Children's Hospital (KASCH), King Abdulaziz Medical City, Ministry of National Guard Health Affairs (MNG-HA), Riyadh, Saudi Arabia KSAU-HS , 7850 Riyadh ,","place":["Saudi Arabia"]},{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs (MNGHA) , 7850 Riyadh ,","place":["Saudi Arabia"]},{"name":"King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs (MNGHA) , 11481 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Karas","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz , 4020 Linz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajeed","family":"Al Subaihin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, King Saud University , 11451 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Al Dibasi","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs (MNGHA) , 11481 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maali","family":"Melha","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Pediatrics, King Abdullah Specialized Children's Hospital (KASCH), King Abdulaziz Medical City, Ministry of National Guard Health Affairs (MNG-HA), Riyadh, Saudi Arabia KSAU-HS , 7850 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeel","family":"Al-Ghamdi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Center , 11211 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijesh","family":"Yadav","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs (MNGHA) , 11481 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suliman","family":"Al Ghanam","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs (MNGHA) , 11481 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Prince Sultan Military Medical City , 12221 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"AlSaedi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Alhada Armed Forces Hospital , 26792 Taif ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enad","family":"Althobaiti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Alhada Armed Forces Hospital , 26792 Taif ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Al Senani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Royal Hospital , 111 Muscat ,","place":["Oman"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Al Azkawi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Royal Hospital , 111 Muscat ,","place":["Oman"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayed","family":"Al Enezi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Al Jahra Hospital , 00008 Al Jahra Governorate ,","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Bakkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Alhada Armed Forces Hospital , 26792 Taif ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Al Jahra Hospital , 00008 Al Jahra Governorate ,","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Al Juraibah","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Pediatrics, King Abdullah Specialized Children's Hospital (KASCH), King Abdulaziz Medical City, Ministry of National Guard Health Affairs (MNG-HA), Riyadh, Saudi Arabia KSAU-HS , 7850 Riyadh ,","place":["Saudi Arabia"]},{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs (MNGHA) , 7850 Riyadh ,","place":["Saudi Arabia"]},{"name":"King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs (MNGHA) , 11481 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Alyaarubi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oman Medical Specialty Board , 233 Muscat ,","place":["Oman"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf","family":"Al Sagheir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Center , 11211 Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-6304","authenticated-orcid":false,"given":"Wolfgang","family":"H\u00f6gler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz , 4020 Linz ,","place":["Austria"]},{"name":"Centre for Growth and Osteology, Department of Paediatrics and Adolescent Medicine, Kepler University Hospital , 4020 Linz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"7","key":"2026101519571487700_dgag226-B1","first-page":"468","article-title":"Hypoparathyroidism-retardation-dysmorphism syndrome","volume":"25","author":"Sanjad","year":"1988","journal-title":"J Med Genet"},{"key":"2026101519571487700_dgag226-B2","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.916679","article-title":"Hypoparathyroidism-retardation-dysmorphism syndrome-clinical insights from a large longitudinal cohort in a single medical center","volume":"10","author":"David","year":"2022","journal-title":"Front Pediatr"},{"issue":"3","key":"2026101519571487700_dgag226-B3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4103\/0971-6866.120814","article-title":"Hypoparathyroidism-retardation-dysmorphism syndrome","volume":"19","author":"Kumar","year":"2013","journal-title":"Indian J Hum Genet"},{"key":"2026101519571487700_dgag226-B4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/B978-0-12-407757-7.00011-6","article-title":"Tubulin-specific chaperones: components of a molecular machine that assembles the \u03b1\/\u03b2 heterodimer","volume":"115","author":"Tian","year":"2013","journal-title":"Methods Cell Biol"},{"key":"2026101519571487700_dgag226-B5","volume-title":"Hypoparathyroidism-retardation-dysmorphism Syndrome [Internet]","author":"National Center for Biotechnology Information","year":"2023"},{"issue":"6","key":"2026101519571487700_dgag226-B6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ajmg.a.31122","article-title":"Hypoparathyroidism-retardation-dysmorphism syndrome in a girl: a new variant not caused by a TBCE mutation\u2013clinical report and review","volume":"140","author":"Courtens","year":"2006","journal-title":"Am J Med Genet A"},{"issue":"8","key":"2026101519571487700_dgag226-B7","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/ajmg.a.38851","article-title":"A case of severe TBCE-negative hypoparathyroidism-retardation-dysmorphism syndrome: case report and literature review","volume":"176","author":"Ryabets-Lienhard","year":"2018","journal-title":"Am J Med Genet A"},{"issue":"10","key":"2026101519571487700_dgag226-B8","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1136\/adc.65.10.1113","article-title":"Short stature, mental retardation, and hypoparathyroidism: a new syndrome","volume":"65","author":"Richardson","year":"1990","journal-title":"Arch Dis Child"},{"issue":"2","key":"2026101519571487700_dgag226-B9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/adc.66.2.193","article-title":"A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features","volume":"66","author":"Sanjad","year":"1991","journal-title":"Arch Dis Child"},{"issue":"2","key":"2026101519571487700_dgag226-B10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s10875-022-01380-9","article-title":"Hypoparathyroidism-retardation-dysmorphism syndrome due to a variant in the tubulin-specific chaperone E gene as a cause of combined immune deficiency","volume":"43","author":"David","year":"2023","journal-title":"J Clin Immunol"},{"issue":"9","key":"2026101519571487700_dgag226-B11","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1210\/clinem\/dgad147","article-title":"Expanding the phenotypic spectrum of Kenny-Caffey syndrome","volume":"108","author":"Schigt","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026101519571487700_dgag226-B12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ng1012","article-title":"Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome","volume":"32","author":"Parvari","year":"2002","journal-title":"Nat Genet"},{"issue":"12","key":"2026101519571487700_dgag226-B13","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1002\/ajmg.a.61896","article-title":"Overlapping phenotype comprising Kenny-Caffey type 2 and Sanjad-Sakati syndromes: the first case report","volume":"182","author":"Cavole","year":"2020","journal-title":"Am J Med Genet A"},{"key":"2026101519571487700_dgag226-B14","first-page":"76","article-title":"WHO child growth standards based on length\/height, weight and age","volume":"450","author":"Group WMGRS","year":"2006","journal-title":"Acta Paediatr Suppl"},{"issue":"4","key":"2026101519571487700_dgag226-B15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.200208001","article-title":"Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease","volume":"159","author":"Bommel","year":"2002","journal-title":"J Cell Biol"},{"key":"2026101519571487700_dgag226-B16","author":"Human Protein Atlas"},{"issue":"8","key":"2026101519571487700_dgag226-B17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1530\/EC-17-0234","article-title":"Impact of intercurrent illness on calcium homeostasis in children with hypoparathyroidism: a case series","volume":"6","author":"Chinoy","year":"2017","journal-title":"Endocr Connect"},{"issue":"12","key":"2026101519571487700_dgag226-B18","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jbmr.4716","article-title":"Management of hypoparathyroidism","volume":"37","author":"Khan","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2026101519571487700_dgag226-B19","article-title":"Recombinant PTH infusion in a child with Sanjad-Sakati syndrome refractory to conventional therapy","volume":"2","author":"Bali","year":"2024","journal-title":"JCEM Case Rep"},{"issue":"2","key":"2026101519571487700_dgag226-B20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpeds.2011.09.022","article-title":"Recombinant parathyroid hormone therapy for severe neonatal hypoparathyroidism","volume":"160","author":"Cho","year":"2012","journal-title":"J Pediatr"},{"key":"2026101519571487700_dgag226-B21","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2016.00172","article-title":"Review of hypoparathyroidism","volume":"7","author":"Abate","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2026101519571487700_dgag226-B22","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1210\/jc.2015-3907","article-title":"Management of hypoparathyroidism: summary statement and guidelines","volume":"101","author":"Brandi","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026101519571487700_dgag226-B23","first-page":"2084","article-title":"Nephrocalcinosis in hypoparathyroidism and the role of calcium supplementation in Sanjad-Sakati syndrome","volume":"102","author":"Bieber","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101519571487700_dgag226-B24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2147\/IJGM.S40930","article-title":"Neurological manifestations in children with Sanjad-Sakati syndrome","volume":"6","author":"Elhassanien","year":"2013","journal-title":"Int J Gen Med"},{"issue":"2","key":"2026101519571487700_dgag226-B25","first-page":"41","article-title":"Autoimmune thyroiditis associated with Sanjad-Sakati syndrome: a call for regular thyroid screening","volume":"16","author":"Anteet","year":"2016","journal-title":"Sudan J Paediatr"},{"issue":"2","key":"2026101519571487700_dgag226-B26","doi-asserted-by":"crossref","first-page":"e907","DOI":"10.1210\/clinem\/dgaa807","article-title":"Multiple endocrine deficiencies are common in hypoparathyroidism-retardation-dysmorphism syndrome","volume":"106","author":"David","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026101519571487700_dgag226-B27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000488352","article-title":"Sanjad-Sakati syndrome: oral health care","volume":"27","author":"Hassona","year":"2018","journal-title":"Med Princ Pract"},{"issue":"9","key":"2026101519571487700_dgag226-B28","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.15537\/1658-3175.4463","article-title":"Prevalence of type 1 diabetes mellitus in Saudi Arabian children and adolescents","volume":"29","author":"Al-Herbish","year":"2008","journal-title":"Saudi Med J"},{"issue":"8","key":"2026101519571487700_dgag226-B29","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/pedi.13454","article-title":"ISPAD clinical practice consensus guidelines 2022: definition, epidemiology, and classification of diabetes in children and adolescents","volume":"23","author":"Libman","year":"2022","journal-title":"Pediatr Diabetes"},{"key":"2026101519571487700_dgag226-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07435800.2024.2388606","article-title":"Monogenic diabetes: a comprehensive overview and therapeutic management of subtypes of Mody","volume":"50","author":"Sharma","year":"2024","journal-title":"Endocr Res"},{"key":"2026101519571487700_dgag226-B31","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109381","article-title":"Type 1 diabetes onset and COVID-19 infection in a child with Sanjad-Sakati syndrome: a case from Kuwait","volume":"186","author":"Othman","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"2026101519571487700_dgag226-B32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.26719\/2009.15.2.345","article-title":"Sanjad-Sakati syndrome\/Kenny-Caffey syndrome type 1: a study of 21 cases in Kuwait","volume":"15","author":"Naguib","year":"2009","journal-title":"East Mediterr Health J"},{"issue":"1","key":"2026101519571487700_dgag226-B33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/imr.12110","article-title":"Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapse","volume":"256","author":"Soares","year":"2013","journal-title":"Immunol Rev"},{"issue":"7","key":"2026101519571487700_dgag226-B34","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1083\/jcb.201811131","article-title":"The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells","volume":"218","author":"S\u00e1ez","year":"2019","journal-title":"J Cell Biol"},{"issue":"4","key":"2026101519571487700_dgag226-B35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1203\/PDR.0b013e31813cbf2d","article-title":"Hypoparathyroidism, retardation, and dysmorphism syndrome: impaired early growth and increased susceptibility to severe infections due to hyposplenism and impaired polymorphonuclear cell functions","volume":"62","author":"Hershkovitz","year":"2007","journal-title":"Pediatr Res"},{"issue":"2","key":"2026101519571487700_dgag226-B36","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11325-021-02463-4","article-title":"Sanjad-Sakati syndrome and sleep-disordered breathing: an undisclosed association","volume":"26","author":"Al-Yaarubi","year":"2022","journal-title":"Sleep Breath"},{"issue":"10","key":"2026101519571487700_dgag226-B37","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s12098-015-1857-5","article-title":"Sleep disordered breathing in children","volume":"82","author":"Grime","year":"2015","journal-title":"Indian J Pediatr"},{"issue":"3","key":"2026101519571487700_dgag226-B38","first-page":"476","article-title":"Kenny-Caffey syndrome with severe respiratory and gastrointestinal involvement: expanding the clinical phenotype","volume":"5","author":"Christodoulou","year":"2015","journal-title":"Quant Imaging Med Surg"},{"issue":"2","key":"2026101519571487700_dgag226-B39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jpedsurg.2009.12.004","article-title":"Visceral myopathy causing chronic intestinal pseudoobstruction and intestinal failure in a child with Sanjad-Sakati syndrome","volume":"45","author":"Pal","year":"2010","journal-title":"J Pediatr Surg"},{"key":"2026101519571487700_dgag226-B40","article-title":"Sanjad-Sakati syndrome and its association with superior mesenteric artery syndrome","volume":"2014","author":"AlAyed","year":"2014","journal-title":"Case Rep Pediatr"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag226\/68504431\/dgag226.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/11\/3075\/68504431\/dgag226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/11\/3075\/68504431\/dgag226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:57:27Z","timestamp":1792108647000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/11\/3075\/8705112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6,10]]},"published-print":{"date-parts":[[2026,10,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag226","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,6,10]]}}}