{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:06Z","timestamp":1792788486586,"version":"4.5.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017521","name":"Esteve","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017521","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HRA pharma","id":[{"id":"https:\/\/ror.org\/059jy0w68","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Mild autonomous cortisol secretion (MACS) is associated with increased mortality, mainly because of cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Here we investigated the effects of cortisol-lowering medical treatment on blood pressure regulation, cardiac fat depots, heart function and morphology, and other cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this secondary analysis of our prospective, open-label, single-center study at the Medical University of Vienna, we investigated 15 patients with MACS (12 women; age 59 [53-64] years) before and after 12 weeks of treatment with evening doses of metyrapone (500 mg at 6 Pm and 250 mg at 10 Pm). Cardiac fat stores, morphology, and myocardial function were evaluated using cardiac magnetic resonance imaging and spectroscopy. Orthostatic blood pressure regulation was measured by standardized protocols. Lipidomics, renin-angiotensin-aldosterone-system activity and branched-chain amino acid (BCAA) concentrations were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean supine systolic (137 [121-139] vs 122 [115-129] mmHg; P = 0.041) and diastolic (89 [80-93] vs 75 [71-86] mmHg; P = .045) blood pressure decreased after treatment in patients without changes in concomitant antihypertensive medication. Epicardial fat was lower at follow-up compared to baseline (1032.70 [894.23-1482.90] vs 929.37 [736.12-1317.15] mm2; P = .022). No changes in paracardial and intramyocardial fat, as well as in cardiac function and morphology were observed. The aldosterone-to-angiotensin II ratio was lower at follow-up (1.56 [0.87-2.82] vs 1.21 [0.98-1.92]; P = .042) and alterations in lipid profiles, but not in BCAA levels, were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with evening doses of metyrapone improved blood pressure and reduced epicardial adipose tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag228","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:32:07Z","timestamp":1781004727000},"page":"3050-3061","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4626-1314","authenticated-orcid":false,"given":"Helena","family":"Niziolek","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Just","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-4011","authenticated-orcid":false,"given":"Clemens","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tosin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5537-506X","authenticated-orcid":false,"given":"Hansj\u00f6rg","family":"Habisch","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz , Graz 8010 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-0971","authenticated-orcid":false,"given":"Paul","family":"Fellinger","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-5737","authenticated-orcid":false,"given":"Hannes","family":"Beiglb\u00f6ck","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Poledniczek","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Bellach","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-6873","authenticated-orcid":false,"given":"Anton","family":"Luger","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-4105","authenticated-orcid":false,"given":"Alexandra","family":"Kautzky-Willer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Trattnig","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Zeyda","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-706X","authenticated-orcid":false,"given":"Thomas","family":"Scherer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-7610","authenticated-orcid":false,"given":"Marie Helene","family":"Schernthaner-Reiter","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian W","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-1959","authenticated-orcid":false,"given":"Greisa","family":"Vila","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-9879","authenticated-orcid":false,"given":"Andreas","family":"Kammerlander","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-5231","authenticated-orcid":false,"given":"Tobias","family":"Madl","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz , Graz 8010 ,","place":["Austria"]},{"name":"BioTechMed-Graz , Graz 8010 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Leutner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Krssak","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-7274","authenticated-orcid":false,"given":"Michael","family":"Krebs","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-734X","authenticated-orcid":false,"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna 1090 ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"issue":"7","key":"2026101519584276500_dgag228-B1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S2213-8587(22)00100-0","article-title":"Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study","volume":"10","author":"Deutschbein","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"8","key":"2026101519584276500_dgag228-B2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41574-024-00984-y","article-title":"Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches","volume":"20","author":"Prete","year":"2024","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"2026101519584276500_dgag228-B3","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1210\/clinem\/dgae204","article-title":"Enhanced chronic inflammation and increased branched-chain amino acids in adrenal disorders: a cross-sectional study","volume":"110","author":"Kittithaworn","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026101519584276500_dgag228-B4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S2213-8587(13)70211-0","article-title":"Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing's syndrome: a 15-year retrospective study","volume":"2","author":"Di Dalmazi","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"2026101519584276500_dgag228-B5","doi-asserted-by":"crossref","first-page":"E2144","DOI":"10.1210\/jc.2014-1783","article-title":"Cardiac structure and function in Cushing's syndrome: a cardiac magnetic resonance imaging study","volume":"99","author":"Kamenick\u00fd","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2026101519584276500_dgag228-B6","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ejendo\/lvae145","article-title":"Cardiovascular status in endogenous cortisol excess: the prospective CV-CORT-EX study","volume":"191","author":"Morbach","year":"2024","journal-title":"Eur J Endocrinol"},{"issue":"18","key":"2026101519584276500_dgag228-B7","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.jacc.2018.07.096","article-title":"Cushing syndrome is associated with subclinical LV dysfunction and increased epicardial adipose tissue","volume":"72","author":"Maurice","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026101519584276500_dgag228-B8","first-page":"3505","article-title":"Epicardial and pericardial adiposity without myocardial steatosis in cushing syndrome","volume":"106","author":"Wolf","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026101519584276500_dgag228-B9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s12020-013-9902-5","article-title":"Epicardial fat thickness and left ventricular mass in subjects with adrenal incidentaloma","volume":"44","author":"Iacobellis","year":"2013","journal-title":"Endocrine"},{"issue":"20","key":"2026101519584276500_dgag228-B10","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.jacc.2018.03.509","article-title":"Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium","volume":"71","author":"Packer","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"2026101519584276500_dgag228-B11","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000582","article-title":"Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations","volume":"3","author":"Fitzgibbons","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"20","key":"2026101519584276500_dgag228-B12","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1161\/01.CIR.0000099542.57313.C5","article-title":"Human epicardial adipose tissue is a source of inflammatory mediators","volume":"108","author":"Mazurek","year":"2003","journal-title":"Circulation"},{"issue":"11","key":"2026101519584276500_dgag228-B13","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCRESAHA.116.306842","article-title":"Lipid use and misuse by the heart","volume":"118","author":"Schulze","year":"2016","journal-title":"Circ Res"},{"issue":"17","key":"2026101519584276500_dgag228-B14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S2213-8587(25)00062-2","article-title":"Surgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomised controlled trial","volume":"13","author":"Tabarin","year":"2025;","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"6","key":"2026101519584276500_dgag228-B15","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/SLA.0000000000006183","article-title":"Adrenalectomy improves body weight, glucose, and blood pressure control in patients with mild autonomous cortisol secretion: results of an randomized controlled trial by the co-work of adrenal research (COAR) study","volume":"279","author":"Koh","year":"2024","journal-title":"Ann Surg"},{"key":"2026101519584276500_dgag228-B16","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2026.103775","article-title":"Metabolic effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a prospective proof-of-concept trial","volume":"92","author":"Niziolek","year":"2026","journal-title":"eClinicalMedicine"},{"issue":"1","key":"2026101519584276500_dgag228-B17","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European network for the study of adrenal tumors","volume":"189","author":"Fassnacht","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"2026101519584276500_dgag228-B18","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1210\/jc.2017-00823","article-title":"Resetting the abnormal circadian cortisol rhythm in adrenal incidentaloma patients with mild autonomous cortisol secretion","volume":"102","author":"Debono","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101519584276500_dgag228-B19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2016.05.033","article-title":"Epicardial and paracardial adipose tissue volume and attenuation\u2014association with high-risk coronary plaque on computed tomographic angiography in the ROMICAT II trial","volume":"251","author":"Lu","year":"2016","journal-title":"Atherosclerosis"},{"issue":"7","key":"2026101519584276500_dgag228-B20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"4","key":"2026101519584276500_dgag228-B21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10334-003-0029-1","article-title":"1H NMR relaxation times of skeletal muscle metabolites at 3 T","volume":"16","author":"Krss\u00e1k","year":"2004","journal-title":"Magma N. Y. N"},{"issue":"1","key":"2026101519584276500_dgag228-B22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1530\/EJE-19-0086","article-title":"Identifying a disease-specific renin-angiotensin-aldosterone system fingerprint in patients with primary adrenal insufficiency","volume":"181","author":"Wolf","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2026101519584276500_dgag228-B23","doi-asserted-by":"crossref","DOI":"10.1530\/EC-24-0617","article-title":"Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing's syndrome","volume":"14","author":"Wolf","year":"2025","journal-title":"Endocr Connect"},{"issue":"1","key":"2026101519584276500_dgag228-B24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40168-024-01774-4","article-title":"Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes-secondary analysis of a randomized placebo-controlled parallel intervention trial","volume":"12","author":"Lackner","year":"2024","journal-title":"Microbiome"},{"issue":"4","key":"2026101519584276500_dgag228-B25","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.12739","article-title":"A branched-chain amino acid-based metabolic score can predict liver fat in children and adolescents with severe obesity","volume":"16","author":"Lischka","year":"2021","journal-title":"Pediatr Obes"},{"key":"2026101519584276500_dgag228-B26","doi-asserted-by":"crossref","unstructured":"Niziolek H, Just I, Baumgartner C, et al \u00a0Supplemental material for \u201cCardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis\u201d. Mendeley Data. 2026. 10.17632\/WG7B9TK5Z3.1","DOI":"10.1210\/clinem\/dgag228"},{"key":"2026101519584276500_dgag228-B27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.898084","article-title":"Adrenalectomy improves blood pressure and metabolic control in patients with possible autonomous cortisol secretion: results of a RCT","volume":"13","author":"Morelli","year":"2022","journal-title":"Front. Endocrinol"},{"issue":"3","key":"2026101519584276500_dgag228-B28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/cen.70056","article-title":"Efficacy and tolerability of metyrapone in mild autonomous cortisol secretion: real-world findings from clinical practice","volume":"104","author":"Berry","year":"2025","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10","key":"2026101519584276500_dgag228-B29","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1210\/jc.2016-2216","article-title":"Effects of hydrocortisone on the regulation of blood pressure: results from a randomized controlled trial","volume":"101","author":"Werumeus Buning","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026101519584276500_dgag228-B30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/HJH.0000000000000415","article-title":"The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications","volume":"33","author":"Isidori","year":"2015","journal-title":"J Hypertens"},{"issue":"1","key":"2026101519584276500_dgag228-B31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1530\/JOE-11-0178","article-title":"The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function","volume":"211","author":"Vinson","year":"2011","journal-title":"J Endocrinol"},{"issue":"9","key":"2026101519584276500_dgag228-B32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41569-022-00679-9","article-title":"Epicardial adipose tissue in contemporary cardiology","volume":"19","author":"Iacobellis","year":"2022","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"2026101519584276500_dgag228-B33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12933-015-0289-x","article-title":"Impact of long-term steroid therapy on epicardial and pericardial fat deposition: a cardiac MRI study","volume":"14","author":"Kitterer","year":"2015","journal-title":"Cardiovasc Diabetol"},{"issue":"14","key":"2026101519584276500_dgag228-B34","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1177\/2047487317717820","article-title":"Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate","volume":"24","author":"Christensen","year":"2017","journal-title":"Eur J Prev Cardiol"},{"issue":"Suppl. 1","key":"2026101519584276500_dgag228-B35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000314213","article-title":"Pathophysiology of dyslipidemia in Cushing's syndrome","volume":"92","author":"Arnaldi","year":"2010","journal-title":"Neuroendocrinology"},{"issue":"3","key":"2026101519584276500_dgag228-B36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/SLA.0b013e31819a47d2","article-title":"Surgical versus conservative management for subclinical cushing syndrome in adrenal incidentalomas: a prospective randomized study","volume":"249","author":"Toniato","year":"2009","journal-title":"Ann Surg"},{"issue":"6","key":"2026101519584276500_dgag228-B37","doi-asserted-by":"crossref","first-page":"R283","DOI":"10.1530\/EJE-16-0465","article-title":"THERAPY OF ENDOCRINE DISEASE: improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and subclinical Cushing's syndrome: a systematic review and meta-analysis","volume":"175","author":"Bancos","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026101519584276500_dgag228-B38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/clinem\/dgae392","article-title":"High LDL particle and APOB concentrations in patients with adrenal cortical adenomas","volume":"110","author":"Sandooja","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026101519584276500_dgag228-B39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/EJE-17-0109","article-title":"Cortisol-related metabolic alterations assessed by mass spectrometry assay in patients with Cushing's syndrome","volume":"177","author":"Di Dalmazi","year":"2017","journal-title":"Eur J Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag228\/68508628\/dgag228.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/11\/3050\/68508628\/dgag228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/11\/3050\/68508628\/dgag228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:58:52Z","timestamp":1792108732000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/11\/3050\/8705575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6,11]]},"published-print":{"date-parts":[[2026,10,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag228","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,6,11]]}}}