{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:12:14Z","timestamp":1784214734565,"version":"3.55.0"},"reference-count":29,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019603","name":"American University of Beirut, Lebanon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"WHO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EMRO"},{"name":"EMRPPH","award":["EMIER1409518"],"award-info":[{"award-number":["EMIER1409518"]}]},{"name":"Scholars in HeAlth Research"},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["D43 TW009118"],"award-info":[{"award-number":["D43 TW009118"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_21003"],"award-info":[{"award-number":["MC_PC_21003"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_21001"],"award-info":[{"award-number":["MC_PC_21001"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022419","name":"NIHR Southampton Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203319"],"award-info":[{"award-number":["NIHR203319"]}],"id":[{"id":"10.13039\/501100022419","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["NIHR305844"],"award-info":[{"award-number":["NIHR305844"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Hypovitaminosis D during pregnancy is common and may have adverse maternal and neonatal effects. While randomized trials show that supplementation improves biochemical vitamin D status, the optimal dose and its effects on neonatal bone outcomes remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effects of 2 vitamin D supplementation doses during pregnancy on maternal and neonatal serum 25-hydroxyvitamin D (25(OH)D) at delivery, and on neonatal bone mineral content.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this double-blind trial, pregnant women \u226417.5 weeks' gestation with baseline 25(OH)D 10 to 30\u2005ng\/mL were randomized to receive either 20 000\u2005IU\/week or 10 000\u2005IU every 2 weeks (equivalent to 714\u2005IU\/day) vitamin D3. Primary outcomes were the proportion of women achieving a 25(OH)D level \u226520\u2005ng\/mL at delivery and neonatal bone mineral content (BMC) at \u223c1 month of age. We used liquid chromatography tandem mass spectrometry (standard LC\u2013MS\/MS) at a CDC-certified laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and ninety-two maternal neonatal pairs had complete biochemical data and 67 neonates had evaluable DXA scans. A significantly higher proportion (100%) of women and neonates (77%) in the higher dose group achieved 25(OH)D levels \u226520\u2005ng\/mL at delivery, compared with the lower dose group (85% and 40%, respectively, P = .001). Mean 25(OH)D in mothers and neonates at delivery followed a similar pattern (P = .001). However, neonatal subtotal whole-body BMC did not differ between groups (45.9 \u00b1 8.5 vs 42.2 \u00b1 7.1\u2005g, respectively; P = .059), nor did neonatal bone mineral density or bone area. We did not identify any safety concerns related to supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher dose vitamin D supplementation safely achieved biochemical sufficiency in mothers and neonates without measurable effect on neonatal bone outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag245","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:41:30Z","timestamp":1784029290000},"source":"Crossref","is-referenced-by-count":0,"title":["Maternal and neonatal outcomes of vitamin D supplementation in hypovitaminosis D pregnancy: preg-D randomized trial"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-986X","authenticated-orcid":false,"given":"Marlene","family":"Chakhtoura","sequence":"first","affiliation":[{"name":"Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut Medical Center , Beirut 6044\/C8 ,","place":["Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar H","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, American University of Beirut Medical Center , Beirut 6044\/C8 ,","place":["Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ajjour","sequence":"additional","affiliation":[{"name":"Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut Medical Center , Beirut 6044\/C8 ,","place":["Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9467-5062","authenticated-orcid":false,"given":"Maya","family":"Rahme","sequence":"additional","affiliation":[{"name":"Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of 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