{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:05:22Z","timestamp":1789517122187,"version":"build-2803163510"},"reference-count":70,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the availability of multiple highly effective pharmacologic therapies for osteoporosis, fracture rates in the United States have plateaued or increased in recent years. At the same time, individuals with osteoporosis are exposed to an abundance of digital health information and frequently seek guidance on nutrition, exercise, and other lifestyle strategies to improve bone health. Many endocrinologists, however, may have limited time or expertise to address these questions comprehensively during routine clinical encounters. Current clinical practice guidelines provide valuable direction on selecting pharmacotherapy based on fracture risk, yet they offer limited guidance on how to personalize treatment plans by integrating patient values, beliefs, and preferences. The aim of this manuscript is to equip clinicians with practical, preference-sensitive strategies to address common concerns raised by postmenopausal women with osteoporosis, including evidence-based guidance on nutrition and on safe, effective resistance, impact, and balance-focused exercises for bone health and fall prevention. We also outline suggested approaches for responding to common concerns among patients who are reluctant to initiate pharmacologic therapy. Through 2 illustrative cases, we highlight how clinicians can integrate pharmacologic options with evidence-based lifestyle guidance and engage patients in shared decision making to develop individualized, goal-concordant care plans. Our goal is to provide clinicians with tools that support more effective, patient-centered conversations and ultimately improve the quality of osteoporosis care.<\/jats:p>","DOI":"10.1210\/clinem\/dgag257","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:18:27Z","timestamp":1782548307000},"page":"2946-2959","source":"Crossref","is-referenced-by-count":0,"title":["Approach to personalizing the treatment of osteoporosis"],"prefix":"10.1210","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3028-6411","authenticated-orcid":false,"given":"Gina","family":"Woods","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, San Diego , La Jolla, CA 92093 ,","place":["USA"]},{"name":"VA San Diego Healthcare System , San Diego, CA 92161 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennalee S","family":"Wooldridge","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System , San Diego, CA 92161 ,","place":["USA"]},{"name":"Department of Psychiatry, University of California, San Diego , La Jolla, CA 92093 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie M","family":"Weaver","sequence":"additional","affiliation":[{"name":"School of Exercise and Nutrition Science, San Diego State University , San Diego, CA 92182 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora","family":"Giangregorio","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Sciences, University of Waterloo , Waterloo, ON N2L 3G1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"issue":"2","key":"2026091519582084700_dgag257-B1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/JS9.0000000000000883","article-title":"Trends in prevalence of fractures among adults in the United States, 1999\u20132020: a population-based study","volume":"110","author":"Xu","year":"2024","journal-title":"Int J Surg"},{"issue":"9","key":"2026091519582084700_dgag257-B2","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1210\/clinem\/dgae840","article-title":"Trends in osteoporosis drug therapy receipt among commercial and medicare advantage enrollees in the United States, 2011-2022","volume":"110","author":"Everhart","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"key":"2026091519582084700_dgag257-B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-025-10090-y","article-title":"Individual and community-level determinants of osteoporosis treatment following fracture among medicare beneficiaries","author":"Wu","year":"2025","journal-title":"J Gen Intern Med"},{"issue":"6","key":"2026091519582084700_dgag257-B4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/03630242.2025.2523258","article-title":"Accessing information on menopause transition and the role of digital health technologies: a narrative review","volume":"65","author":"Osborne","year":"2025","journal-title":"Women Health"},{"key":"2026091519582084700_dgag257-B5","doi-asserted-by":"crossref","DOI":"10.1016\/j.pec.2023.107809","article-title":"Effect of age on U.S. gynecologic patients\u2019 use of social media for women's health information","volume":"114","author":"Bringley","year":"2023","journal-title":"Patient Educ Couns"},{"issue":"3","key":"2026091519582084700_dgag257-B6","doi-asserted-by":"crossref","first-page":"e11240","DOI":"10.2196\/11240","article-title":"Electronic health behaviors among US adults with chronic disease: cross-sectional survey","volume":"21","author":"Madrigal","year":"2019","journal-title":"J Med Internet Res"},{"issue":"3","key":"2026091519582084700_dgag257-B7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.eprac.2021.12.012","article-title":"An assessment of nutrition education in endocrinology fellowship programs in the United States","volume":"28","author":"Bassin","year":"2022","journal-title":"Endocr Pract"},{"issue":"8","key":"2026091519582084700_dgag257-B8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0330861","article-title":"Health care professionals\u2019 attitudes, behaviours and barriers toward exercise promotion among patients: a systematic review","volume":"20","author":"Avsar","year":"2025","journal-title":"PLoS One"},{"issue":"9","key":"2026091519582084700_dgag257-B9","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00198-025-07614-x","article-title":"OsteoStrong and bone health: a scoping review","volume":"36","author":"Kabra","year":"2025","journal-title":"Osteoporos Int"},{"issue":"7023","key":"2026091519582084700_dgag257-B10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.312.7023.71","article-title":"Evidence based medicine: what it is and what it isn\u2019t","volume":"312","author":"Sackett","year":"1996","journal-title":"BMJ"},{"issue":"7","key":"2026091519582084700_dgag257-B11","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00198-019-04913-y","article-title":"Evidence of patient beliefs, values, and preferences is not provided in osteoporosis clinical practice guidelines","volume":"30","author":"Sale","year":"2019","journal-title":"Osteoporos Int"},{"issue":"11","key":"2026091519582084700_dgag257-B12","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11606-008-0772-0","article-title":"Patient decision to initiate therapy for osteoporosis: the influence of knowledge and beliefs","volume":"23","author":"Yood","year":"2008","journal-title":"J Gen Intern Med"},{"issue":"12","key":"2026091519582084700_dgag257-B13","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1185\/030079907X242890","article-title":"The impact of osteoporosis medication beliefs and side-effect experiences on non-adherence to oral bisphosphonates","volume":"23","author":"McHorney","year":"2007","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"2026091519582084700_dgag257-B14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11914-013-0133-8","article-title":"Adherence with medications used to treat osteoporosis: behavioral insights","volume":"11","author":"Schousboe","year":"2013","journal-title":"Curr Osteoporos Rep"},{"key":"2026091519582084700_dgag257-B15"},{"key":"2026091519582084700_dgag257-B16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fnbeh.2014.00076","article-title":"Does temporal discounting explain unhealthy behavior? A systematic review and reinforcement learning perspective","volume":"8","author":"Story","year":"2014","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"2026091519582084700_dgag257-B17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/17437190701492437","article-title":"Temporal self-regulation theory: a model for individual health behavior","volume":"1","author":"Hall","year":"2007","journal-title":"Health Psychol Rev"},{"issue":"2","key":"2026091519582084700_dgag257-B18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pec.2013.07.012","article-title":"Motivational interviewing in medical care settings: a systematic review and meta-analysis of randomized controlled trials","volume":"93","author":"Lundahl","year":"2013","journal-title":"Patient Educ Couns"},{"issue":"1","key":"2026091519582084700_dgag257-B19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/1742395313495572","article-title":"The components of action planning and their associations with behavior and health outcomes","volume":"10","author":"Lorig","year":"2014","journal-title":"Chronic Illn"},{"issue":"4","key":"2026091519582084700_dgag257-B20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF01663995","article-title":"Analysis of self-efficacy theory of behavioral change","volume":"1","author":"Bandura","year":"1977","journal-title":"Cogn Ther Res"},{"issue":"19","key":"2026091519582084700_dgag257-B21","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1001\/jama.2018.14854","volume":"320","author":"Piercy KL, Troiano RP, Ballard RM","year":"2018","journal-title":"JAMA"},{"issue":"6","key":"2026091519582084700_dgag257-B22","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1080\/02640414.2017.1329549","article-title":"Effectiveness of peers in delivering programs or motivating older people to increase their participation in physical activity: systematic review and meta-analysis","volume":"36","author":"Burton","year":"2018","journal-title":"J Sports Sci"},{"issue":"1","key":"2026091519582084700_dgag257-B23","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1186\/s12889-015-2270-8","article-title":"Understanding for whom, under what conditions, and how group-based physical activity interventions are successful: a realist review","volume":"15","author":"Harden","year":"2015","journal-title":"BMC Public Health"},{"issue":"7","key":"2026091519582084700_dgag257-B24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7326\/0003-4819-126-7-199704010-00001","article-title":"Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women","volume":"126","author":"Curhan","year":"1997","journal-title":"Ann Intern Med"},{"issue":"6","key":"2026091519582084700_dgag257-B25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/nutrit\/nuz002","article-title":"A proposed nutrient density score that includes food groups and nutrients to better align with dietary guidance","volume":"77","author":"Drewnowski","year":"2019","journal-title":"Nutr Rev"},{"issue":"4","key":"2026091519582084700_dgag257-B26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/NT.0000000000000691","article-title":"Sorting dietary advice for bone health","volume":"59","author":"Weaver","year":"2024","journal-title":"Nutr Today"},{"issue":"7","key":"2026091519582084700_dgag257-B27","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3945\/jn.115.227256","article-title":"Soluble corn fiber increases calcium absorption associated with shifts in the gut microbiome: a randomized dose-response trial in free-living pubertal females","volume":"146","author":"Whisner","year":"2016","journal-title":"J Nutr"},{"issue":"7","key":"2026091519582084700_dgag257-B28","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026091519582084700_dgag257-B29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/jbmr.3958","article-title":"Effects of supplemental vitamin D on bone health outcomes in women and men in the VITamin D and OmegA-3 TriaL (VITAL)","volume":"35","author":"LeBoff","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"18","key":"2026091519582084700_dgag257-B30","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1001\/jama.2020.16909","article-title":"Effect of vitamin D supplementation, Omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH randomized clinical trial","volume":"324","author":"Bischoff-Ferrari","year":"2020","journal-title":"JAMA"},{"issue":"6","key":"2026091519582084700_dgag257-B31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11914-024-00893-z","article-title":"Vitamin D-do diet recommendations for health remain strong?","volume":"22","author":"Weaver","year":"2024","journal-title":"Curr Osteoporos Rep"},{"issue":"8","key":"2026091519582084700_dgag257-B32","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1210\/clinem\/dgae290","article-title":"Vitamin D for the prevention of disease: an endocrine society clinical practice guideline","volume":"109","author":"Demay","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2026091519582084700_dgag257-B33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/advances\/nmab044","article-title":"Perspective: framework for developing recommended intakes of bioactive dietary substances","volume":"12","author":"Yates","year":"2021","journal-title":"Adv Nutr"},{"issue":"17","key":"2026091519582084700_dgag257-B34","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1001\/jama.2017.15006","article-title":"Comparisons of interventions for preventing falls in older adults: a systematic review and meta-analysis","volume":"318","author":"Tricco","year":"2017","journal-title":"JAMA"},{"issue":"10","key":"2026091519582084700_dgag257-B35","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1111\/jgs.17375","article-title":"Interventions for preventing falls and fall-related fractures in community-dwelling older adults: a systematic review and network meta-analysis","volume":"69","author":"Dautzenberg","year":"2021","journal-title":"J Am Geriatr Soc"},{"key":"2026091519582084700_dgag257-B36","article-title":"Exercise for preventing falls in older people living in the community","volume":"1","author":"Sherrington","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2026091519582084700_dgag257-B37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jama.2024.4166","article-title":"Interventions to prevent falls in older adults: updated evidence report and systematic review for the US preventive services task force","volume":"332","author":"Guirguis-Blake","year":"2024","journal-title":"JAMA"},{"key":"2026091519582084700_dgag257-B38","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111151","article-title":"Comparative effectiveness of exercise interventions for preventing falls in older adults: a secondary analysis of a systematic review with network meta-analysis","volume":"143","author":"Sibley","year":"2021","journal-title":"Exp Gerontol"},{"issue":"15","key":"2026091519582084700_dgag257-B39","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/bjsports-2019-101512","article-title":"Exercise for preventing falls in older people living in the community: an abridged Cochrane systematic review","volume":"54","author":"Sherrington","year":"2020","journal-title":"Br J Sports Med"},{"issue":"24","key":"2026091519582084700_dgag257-B40","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br J Sports Med"},{"issue":"9","key":"2026091519582084700_dgag257-B41","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac205","article-title":"World guidelines for falls prevention and management for older adults: a global initiative","volume":"51","author":"Montero-Odasso","year":"2022","journal-title":"Age Ageing"},{"issue":"1","key":"2026091519582084700_dgag257-B42","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1532-5415.2010.03234.x","article-title":"Summary of the updated American geriatrics society\/British geriatrics society clinical practice guideline for prevention of falls in older persons","volume":"59","author":"Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"2026091519582084700_dgag257-B43","article-title":"The effect of exercise intensity on bone in postmenopausal women (part 1): a systematic review","volume":"143","author":"Kistler-Fischbacher","year":"2021","journal-title":"Bone"},{"issue":"2","key":"2026091519582084700_dgag257-B44","doi-asserted-by":"crossref","DOI":"10.1093\/ptj\/pzaa221","article-title":"Progressive resistance training for improving health-related outcomes in people at risk of fracture: a systematic review and meta-analysis of randomized controlled trials","volume":"101","author":"Ponzano","year":"2021","journal-title":"Phys Ther"},{"issue":"6","key":"2026091519582084700_dgag257-B45","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s40279-021-01432-x","article-title":"The effect of impact exercise (alone or multicomponent intervention) on health-related outcomes in individuals at risk of fractures: a systematic review and meta-analysis of randomized controlled trials","volume":"51","author":"Rodrigues","year":"2021","journal-title":"Sports Med"},{"issue":"1","key":"2026091519582084700_dgag257-B46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.11005\/jbm.2021.28.1.27","article-title":"Physical activity and bone health in men: a systematic review and meta-analysis","volume":"28","author":"Ashe","year":"2021","journal-title":"J Bone Metab"},{"issue":"5","key":"2026091519582084700_dgag257-B47","first-page":"886","article-title":"The effects of walking or Nordic Walking in adults 50 years and older at elevated risk of fractures: a systematic review and meta-analysis","volume":"29","author":"Rodrigues","year":"2021","journal-title":"J Aging Phys Act"},{"key":"2026091519582084700_dgag257-B48","article-title":"The effect of exercise intensity on bone in postmenopausal women (part 2): a meta-analysis","volume":"143","author":"Kistler-Fischbacher","year":"2021","journal-title":"Bone"},{"issue":"7","key":"2026091519582084700_dgag257-B49","first-page":"CD000333","article-title":"Exercise for preventing and treating osteoporosis in postmenopausal women","volume":"2011","author":"Howe","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"2026091519582084700_dgag257-B50","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1249\/MSS.0000000000003897","article-title":"American college of sports medicine position stand. Resistance training prescription for muscle function, hypertrophy, and physical performance in healthy adults: an overview of reviews","volume":"58","author":"Currier","year":"2026","journal-title":"Med Sci Sports Exerc"},{"issue":"6","key":"2026091519582084700_dgag257-B51","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1159\/000519511","article-title":"Does whole-body vibration training have a concurrent effect on bone and muscle health? A systematic review and meta-analysis","volume":"68","author":"Harijanto","year":"2022","journal-title":"Gerontology"},{"issue":"6","key":"2026091519582084700_dgag257-B52","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.16772","article-title":"Weighted vest use or resistance exercise to offset weight loss\u2013associated bone loss in older adults: a randomized clinical trial","volume":"8","author":"Beavers","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"3","key":"2026091519582084700_dgag257-B53","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00198-014-2881-4","article-title":"Too fit to fracture: outcomes of a Delphi consensus process on physical activity and exercise recommendations for adults with osteoporosis with or without vertebral fractures","volume":"26","author":"Giangregorio","year":"2015","journal-title":"Osteoporos Int"},{"issue":"1","key":"2026091519582084700_dgag257-B54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jbmr.534","article-title":"Bone mineral density loss in relation to the final menstrual period in a multi-ethic cohort: results from the study of Women's health across the nation (SWAN)","volume":"27","author":"Greendale","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2026091519582084700_dgag257-B55","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/jbmr\/zjae119","article-title":"Goal-directed osteoporosis treatment: ASBMR\/BHOF task force position statement 2024","volume":"39","author":"Cosman","year":"2024","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2026091519582084700_dgag257-B56","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1210\/clinem\/dgaa048","article-title":"Pharmacological management of osteoporosis in postmenopausal women: an endocrine society guideline update","volume":"105","author":"Shoback","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"2026091519582084700_dgag257-B57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/GL-2020-0524SUPPL","article-title":"American Association of Clinical Endocrinologists\/AMERICAN College of Endocrinology Clinical Practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update","volume":"26","author":"Camacho","year":"2020","journal-title":"Endocr Pract"},{"issue":"2","key":"2026091519582084700_dgag257-B58","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00198-015-3249-0","article-title":"Disparities in osteoporosis treatments","volume":"27","author":"Liu","year":"2016","journal-title":"Osteoporos Int J"},{"issue":"7","key":"2026091519582084700_dgag257-B59","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00198-019-04952-5","article-title":"Factors affecting willingness to get assessed and treated for osteoporosis","volume":"30","author":"Roh","year":"2019","journal-title":"Osteoporos Int J"},{"issue":"12","key":"2026091519582084700_dgag257-B60","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1089\/jwh.2016.6263","article-title":"Reasons for not treating women with postmenopausal osteoporosis with prescription medications: physicians\u2019 and patients\u2019 perspectives","volume":"26","author":"Weaver","year":"2017","journal-title":"J Womens Health"},{"issue":"16","key":"2026091519582084700_dgag257-B61","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N Engl J Med"},{"issue":"7","key":"2026091519582084700_dgag257-B62","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"2026091519582084700_dgag257-B63","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/jbmr\/zjae196","article-title":"Verifying the effectiveness of romosozumab re-administration on bone mineral density","volume":"40","author":"Kobayakawa","year":"2025","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2026091519582084700_dgag257-B64","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1359\/jbmr.060312","article-title":"Effects of conjugated equine estrogen on risk of fractures and BMD in postmenopausal women with hysterectomy: results from the women's health initiative randomized trial","volume":"21","author":"Jackson","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"13","key":"2026091519582084700_dgag257-B65","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1001\/jama.290.13.1729","article-title":"Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's health initiative randomized trial","volume":"290","author":"Cauley","year":"2003","journal-title":"JAMA"},{"issue":"1","key":"2026091519582084700_dgag257-B66","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/13697137.2021.1957818","article-title":"Hormone therapy for postmenopausal osteoporosis management","volume":"25","author":"Jiang","year":"2022","journal-title":"Climacteric J Int Menopause Soc"},{"issue":"23","key":"2026091519582084700_dgag257-B67","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1001\/jama.281.23.2189","article-title":"The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple outcomes of raloxifene evaluation","volume":"281","author":"Cummings","year":"1999","journal-title":"JAMA"},{"issue":"10","key":"2026091519582084700_dgag257-B68","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1097\/GME.0000000000000694","article-title":"Effect of conjugated estrogens\/bazedoxifene on postmenopausal bone loss: pooled analysis of two randomized trials","volume":"23","author":"Gallagher","year":"2016","journal-title":"Menopause"},{"issue":"5","key":"2026091519582084700_dgag257-B69","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/AOG.0b013e31828c5974","article-title":"Breast effects of bazedoxifene-conjugated estrogens: a randomized controlled trial","volume":"121","author":"Pinkerton","year":"2013","journal-title":"Obstet Gynecol"},{"key":"2026091519582084700_dgag257-B70","author":"Fabian"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag257\/68631393\/dgag257.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/10\/2946\/68631393\/dgag257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/111\/10\/2946\/68631393\/dgag257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:58:33Z","timestamp":1789516713000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/111\/10\/2946\/8719394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":70,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,6,27]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag257","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,6,27]]}}}