{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:13:23Z","timestamp":1788970403065,"version":"build-2803163510"},"reference-count":80,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK109932"],"award-info":[{"award-number":["R01 DK109932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 MH120568"],"award-info":[{"award-number":["K24 MH120568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK040561"],"award-info":[{"award-number":["P30DK040561"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018644","name":"Boston Nutrition Obesity Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018644","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Massachusetts General Hospital Department of Medicine Eleanor"},{"name":"Miles Shore Fellowship Award"},{"DOI":"10.13039\/100015334","name":"Endocrine Fellows Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001102"],"award-info":[{"award-number":["UL1TR001102"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Oxytocin (OXT) is an anorexigenic, anxiolytic, and antidepressant neurohormone under investigation for obesity treatment. Mechanisms underlying OXT psychological effects are not fully understood, and human data on OXT modulation of the thyroid axis are lacking. Our 8-week trial of intranasal OXT in adults with obesity showed improved mental health\u2013related quality of life (MHQoL) measured by the Short-Form 36 Health Survey vs placebo. Increased T4 and decreased T3 have been linked to depression. The free (bioactive) T3 (fT3)\/free T4 (fT4) ratio, a marker of thyroid function in euthyroid patients, is associated with improved mental health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether 6 weeks of intranasal OXT vs placebo modulates (1) the thyroid axis and (2) the relationship between fT3\/fT4 and MHQoL changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Eight-week randomized clinical trial, secondary analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary academic center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Sixty-one adults with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Eight weeks of intranasal OXT (24 IU) 4\u00d7 daily or placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Pre- and posttreatment fasting thyroid hormones (week 6) and MHQoL (week 8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six weeks of intranasal OXT vs placebo impacted fT3\/fT4 (treatment \u00d7 time P = .045), with an increase in the OXT group (P = .048) and no change in the placebo group (P = .406). TSH, fT4, and fT3 did not change (P \u2265 .154). OXT vs placebo impacted the relationship between fT3\/fT4 (6 weeks) and MHQoL (8 weeks) changes (treatment \u00d7 \u0394[fT3\/fT4] P = .023); increased fT3\/fT4 was positively associated with MHQoL improvement (trend-level P = .088).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prolonged OXT vs placebo increased fT3\/fT4 and impacted the relationship between fT3\/fT4 and MHQoL changes, with a trend-level positive correlation between fT3\/fT4 and MHQoL change scores. OXT action on fT3\/fT4 may underpin OXT-induced mental health benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>NCT03043053.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag291","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:37:01Z","timestamp":1788867421000},"source":"Crossref","is-referenced-by-count":0,"title":["Oxytocin-induced changes in free T3\/free T4 ratio and relationship with quality of life in adults with obesity"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-2541","authenticated-orcid":false,"given":"Francesca","family":"Galbiati","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Division of 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Department of Medicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Muhammed","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Plessow","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco , San Francisco, CA 94143 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