{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:25:23Z","timestamp":1786112723484,"version":"build-2736575974"},"reference-count":25,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003484","name":"Heinrich Heine University D\u00fcsseldorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003484","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ilse-Bagel Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Neonatal hypoglycemia is the most common metabolic disorder in newborns and may lead to adverse neurodevelopment. The role of alternative substrates, such as beta-hydroxybutyrate (BOHB), during neonatal hypoglycemia is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine BOHB in neonates with and without hypoglycemia risk factors across different feeding regimens and to estimate the potential to guide discontinuation of blood glucose (BG) screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study (May 2020 to September 2022). Standardized BG and BOHB measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single-center tertiary hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Eight hundred ninety-five neonates with (n = 752) and without (n = 143, controls) hypoglycemia risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes measures<\/jats:title>\n                    <jats:p>Comparison of BG and combined BG + BOHB values and percentiles across different risk factors and feeding regimens. Ketonemia was defined as BOHB &amp;gt; 0.5\u2005mmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 516 neonates with BOHB measurements at \u226524\u2005hours of age, 107 (20.7%) had ketonemia. Ketonemia was more frequent in controls than in at-risk neonates (28.2% [33\/117] vs 18.6% [74\/399], P = .023) and in neonates receiving exclusively breastmilk than in exclusively formula-fed neonates (34% [16\/47] vs 3% [1\/39], P &amp;lt; .001). BG and BG + BOHB percentile trajectories diverged more over time in controls, large-for-gestational-age neonates, and infants of diabetic mothers than in small-for-gestational and\/or fetal-growth-restricted, preterm, or perinatally stressed neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neonates with hypoglycemia risk factors and those receiving formula developed less ketonemia. The low overall incidence of ketonemia and its dependence on feeding regimen\u2014particularly among at-risk neonates\u2014limit the utility of BOHB, alone or in combination with BG, as a broadly applicable marker for determining when hypoglycemia screening can be safely discontinued.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag300","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:41:40Z","timestamp":1784893300000},"source":"Crossref","is-referenced-by-count":1,"title":["Physiology and diagnostic potential of beta-hydroxybutyrate in neonatal glycemia\u2014a prospective cohort study"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-0633","authenticated-orcid":false,"given":"Henrike","family":"Hoermann","sequence":"first","affiliation":[{"name":"Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University 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