{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:52:30Z","timestamp":1787727150014,"version":"build-2784847793"},"reference-count":37,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102093"],"award-info":[{"award-number":["82102093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["CSTB2025NSCQ-GPX1138"],"award-info":[{"award-number":["CSTB2025NSCQ-GPX1138"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate 68Ga-pentixafor positron emission tomography\/computed tomography (PET\/CT) in the surgical management of primary aldosteronism (PA), with emphasis on its relationship with adrenal venous sampling (AVS), KCNJ5 mutation status, tracer uptake, and postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In this retrospective single-center cohort study, 929 consecutive patients with suspected PA were screened from November 2021 to February 2025. The final cohort included 162 patients who underwent unilateral adrenalectomy and 6-month follow-up; 83 also underwent AVS. Patients treated before September 2024 followed an AVS-guided pathway, and those treated thereafter followed a PET\/CT-guided pathway. Outcomes were assessed by PA Surgical Outcome criteria. Firth logistic regression, overlap weighting, paired PET\/CT-vs-AVS analysis, and genotype-stratified analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical and biochemical complete success did not differ significantly between the PET-guided and AVS-guided groups. Among patients with both tests, unilateral PET\/CT showed high positive predictive value vs AVS (56\/57, 98.2%), but 26 of 82 AVS-confirmed unilateral PA cases had negative or bilateral PET findings. All KCNJ5-mutated patients in the PET-status cohort were PET-positive, whereas 22 of 52 KCNJ5-nonmutated patients were PET-negative. KCNJ5 mutation and CT lesion size were independently associated with PET positivity. The maximum standardized uptake value (SUVmax) lateralization index was associated with biochemical complete success, including within KCNJ5-nonmutated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>68Ga-pentixafor PET\/CT provides strong rule-in information when uptake is clearly unilateral. Negative or bilateral PET\/CT findings, particularly in patients with small or KCNJ5-nonmutated lesions, should be interpreted cautiously and should not preclude AVS-based evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag301","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:11:04Z","timestamp":1785323464000},"source":"Crossref","is-referenced-by-count":1,"title":["KCNJ5-dependent 68Ga-pentixafor positron emission tomography\/computed tomography in primary aldosteronism surgery"],"prefix":"10.1210","author":[{"given":"Zhengjie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Bai","sequence":"additional","affiliation":[{"name":"The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongpeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-6445","authenticated-orcid":false,"given":"Qifu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-3208","authenticated-orcid":false,"given":"Hua","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of 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