{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:33:33Z","timestamp":1787672013850,"version":"build-2736575974"},"reference-count":44,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001034","name":"ALF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning, \u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M24-0287"],"award-info":[{"award-number":["M24-0287"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs l\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","award":["GLS-1021811"],"award-info":[{"award-number":["GLS-1021811"]}],"id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS-999075"],"award-info":[{"award-number":["SLS-999075"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2023-02144"],"award-info":[{"award-number":["2023-02144"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","award":["2024-0678"],"award-info":[{"award-number":["2024-0678"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","award":["2025-0583"],"award-info":[{"award-number":["2025-0583"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Secondary diabetes mellitus occurs in 30% to 50% of patients with acromegaly despite a lean phenotype, whereas type 2 diabetes mellitus (T2DM) is associated with adiposity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We compared mortality, morbidity, and treatment patterns between patients with acromegaly-associated diabetes (ACRO-DM) and T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Nationwide, retrospective, matched-cohort study in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ACRO-DM group included patients with an acromegaly diagnosis in the Patient Register, with diabetes registered in the National Diabetes Register (NDR) or a dispensed glucose-lowering drug in the Prescribed Drug Register. Controls with T2DM from the NDR were matched 10:1 for sex, age, calendar year, and diabetes duration. We derived mortality and morbidity outcomes from the Death and Patient Registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 348 patients with ACRO-DM and 3480 with T2DM. Mean (SD) age was 60.3 (13.2) and 59.5 (15.6) years, whereas diabetes duration was 2.8 (5.8) and 3.0 (7.1) years in ACRO-DM and T2DM, respectively. Baseline cardiovascular morbidity was more common in ACRO-DM than T2DM group (61% vs 43%), including hypertension (48% vs 29%), heart failure (11% vs 5%), arrhythmia (13% vs 9%), and stroke (8% vs 5%).<\/jats:p>\n                    <jats:p>The hazard ratio (HR) for overall mortality was 1.18 (95% CI, 0.96-1.46) in ACRO-DM compared with T2DM group. The ACRO-DM group had a higher risk of cardiovascular morbidity (HR = 1.55; 95% CI, 1.24-1.94), with increased hazards for venous thromboembolism, specifically pulmonary, and arrhythmia, whereas cardiovascular mortality was not increased (HR = 1.12; 95% CI, 0.78-1.60).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The risk of cardiovascular morbidity was increased in patients with ACRO-DM compared to T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag322","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:12:46Z","timestamp":1786101166000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular morbidity and mortality in acromegaly-associated diabetes: a Swedish nationwide study"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7768-2515","authenticated-orcid":false,"given":"Angelo","family":"Milioto","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg , 413 46 Gothenburg ,","place":["Sweden"]},{"name":"Department of Endocrinology, Sahlgrenska University Hospital , 413 46 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Ragnarsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg , 413 46 Gothenburg ,","place":["Sweden"]},{"name":"Department of Endocrinology, Sahlgrenska University Hospital , 413 46 Gothenburg ,","place":["Sweden"]},{"name":"Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg , 413 45 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Ferone","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Internal Medicine and Medical Specialties, School of Medical and Pharmaceutical Sciences, University of Genova , 16132 Genoa ,","place":["Italy"]},{"name":"Endocrinology Unit, IRCCS Ospedale Policlinico San Martino , 16132 Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-589X","authenticated-orcid":false,"given":"Martin","family":"Adiels","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg , 413 20 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Gustav","family":"Smith","sequence":"additional","affiliation":[{"name":"The Wallenberg Laboratory\/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital , 413 45 Gothenburg ,","place":["Sweden"]},{"name":"Department of Cardiology, Clinical Sciences, Lund University and Sk\u00e5ne University Hospital , 221 85 Lund ,","place":["Sweden"]},{"name":"Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University , 221 85 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-6605","authenticated-orcid":false,"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , 413 45 Gothenburg ,","place":["Sweden"]},{"name":"Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital, \u00d6stra Hospital, Region V\u00e4stra G\u00f6taland , 416 85 Gothenburg 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