{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:05:17Z","timestamp":1789747517800,"version":"4.0.1"},"reference-count":42,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advances in research enable precision medicine for rare metabolic diseases. The approval of therapies as melanocortin-4 receptor agonists for the treatment of hyperphagia and obesity in monogenic disorders (proopiomelanocortin, proprotein convertase subtilisin\/kexin type 1, and leptin receptor deficiencies) and Bardet\u2013Biedl syndrome, affecting fewer than 1 in 20 000 to 1 000 000 individuals, represents a major advance. These therapies have transformative potential but introduce new responsibilities due to limited patient numbers and lack of long-term data. Equitable access to diagnosis and treatment, expert care, and structured monitoring systems facilitate efficient use of resources and can address gaps in knowledge. This article outlines a European expert consensus recommending the designation of centers of expertise to coordinate the diagnosis and treatment of patients with monogenic obesity. The need for structured care protocols based on continued analysis of real-world databases to optimize therapy in a responsible manner is emphasized. The goals are (1) early and precise diagnosis, (2) access for eligible patients to therapy, (3) continuous evaluation of treatment response allowing discontinuation when there is no measurable clinical benefit, and (4) provision of clinical care by trained and experienced professionals.<\/jats:p>","DOI":"10.1210\/clinem\/dgag330","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:14:03Z","timestamp":1786702443000},"source":"Crossref","is-referenced-by-count":0,"title":["Precision medicine in patients with rare forms of genetic obesity: necessity for coordinated and structured care"],"prefix":"10.1210","author":[{"given":"Karine","family":"Cl\u00e9ment","sequence":"first","affiliation":[{"name":"Sorbonne University, INSERM, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit , 75013 Paris ,","place":["France"]},{"name":"Assistance Publique-Hopitaux de Paris, Nutrition Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , 75013 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