{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:25:15Z","timestamp":1790958315669,"version":"4.1.0"},"reference-count":41,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the results of patient-reported outcome measures (PROMs) by disease activity in a national cohort of females with a prolactinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Females with prolactinoma included in the PRolaCT or ProlaC study were assessed cross-sectionally, comparing patients with active (prolactin above upper limit of normal [ULN]) and controlled (prolactin &amp;lt; ULN) disease. Disease and treatment characteristics were reported. Patients completed PROMs on symptoms (modified PRO-CTCAE), health-related quality of life (HR-QoL) (SF-36), anxiety and depressive symptoms (Hospital Anxiety and Depression Scale (HADS)), and disease burden (Leiden Bother and Needs Questionnaire for patients with Pituitary disease [LBNQ-Pituitary]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 450 females with a prolactinoma were included (active: n = 223, controlled: n = 227); most (97.0%) were treated with dopamine agonists (DAs). Fatigue was the most prevalent symptom in both patients with active and controlled disease (92.6%, and 86.4%, respectively) followed by concentration problems (79.0%, and 64.5%, respectively) (modified PRO-CTCAE, LBNQ-Pituitary). Anxiety and depressive symptoms were worse in patients with active compared to controlled disease (HADS-Anxiety: 8.0 \u00b1 4.5 vs 6.4 \u00b1 4.5 P &amp;lt; .001. HADS-Depression: 6.4 \u00b1 5.0 vs 4.7 \u00b1 4.4 P &amp;lt; .001). Disease burden was higher in patients with active compared to controlled disease (LBNQ-Pituitary: Total Bother 24.4 \u00b1 22.9 vs 16.4 \u00b1 17.9; P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Females with a prolactinoma were most affected by fatigue and cognitive complaints. Although patients with active disease perceived more burden than patients with controlled disease, symptoms including fatigue and psychological and cognitive complaints were prevalent despite disease control. Therefore, improvement of treatment and rehabilitation strategies is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag331","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:21:32Z","timestamp":1786620092000},"source":"Crossref","is-referenced-by-count":2,"title":["The Dutch prolactinoma cohort studies: cross-sectional analysis of females focusing on the patient's perspective"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-0679","authenticated-orcid":false,"given":"Victoria R","family":"van Trigt","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-4037","authenticated-orcid":false,"given":"Iris C M","family":"Pelsma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-8273","authenticated-orcid":false,"given":"Ingrid M","family":"Zandbergen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Neurosurgical Center Holland, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3549-0184","authenticated-orcid":false,"given":"Leontine E H","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-7580","authenticated-orcid":false,"given":"Olaf M","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-2070","authenticated-orcid":false,"given":"Amir H","family":"Zamanipoor Najafabadi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2154-4923","authenticated-orcid":false,"given":"Saskia","family":"le Cessie","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]},{"name":"Department of Biomedical Data Science, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-509X","authenticated-orcid":false,"given":"M Elske","family":"van den Akker-van Marle","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science, Unit Medical Decision Making, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-2509","authenticated-orcid":false,"given":"Madeleine L","family":"Drent","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Amsterdam Gastroenterology, Endocrinology and Metabolism, (AGEM), Amsterdam UMC, University of Amsterdam , 1105 AZ Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-5140","authenticated-orcid":false,"given":"Dirk Jan","family":"Stenvers","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Amsterdam Gastroenterology, Endocrinology and Metabolism, (AGEM), Amsterdam UMC, University of Amsterdam , 1105 AZ Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid I L","family":"Berk-Planken","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Franciscus Gasthuis and Vlietland Hospital , Rotterdam\/Schiedam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"van den Berge","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Admiraal de Ruyter Hospital , Goes\/Vlissingen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-8672","authenticated-orcid":false,"given":"Merel","family":"van Andel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haaglanden Medical Center , 2512 VA The Hague ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty","family":"Kapiteijn","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Reinier de Graaf Hospital , 2600 GA Delft ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne G H A","family":"Swinnen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rijnstate Hospital , Arnhem, 6800 TA ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3400-734X","authenticated-orcid":false,"given":"Aline M E","family":"Stades","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine and Endocrinology, University Medical Center Utrecht , 3508 GA Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-391X","authenticated-orcid":false,"given":"Richard A","family":"Feelders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center , 3015 GD Rotterdam ,","place":["the Netherlands"]},{"name":"Division of Endocrinology, Diabetes and Metabolism, New York University Langone Medical Center , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0977-5690","authenticated-orcid":false,"given":"Annenienke C","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center , 6525 GA Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-8070","authenticated-orcid":false,"given":"Jantien","family":"Hoogmoed","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Amsterdam UMC, University of Amsterdam , 1105 AZ Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-009X","authenticated-orcid":false,"given":"Melanie M","family":"van der Klauw","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-9866","authenticated-orcid":false,"given":"Alberto M","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Amsterdam Gastroenterology, Endocrinology and Metabolism, (AGEM), Amsterdam UMC, University of Amsterdam , 1105 AZ Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-8701","authenticated-orcid":false,"given":"Cornelie D","family":"Andela","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-7515","authenticated-orcid":false,"given":"Marco J T","family":"Verstegen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Neurosurgical Center Holland, Leiden University Medical Center , Leiden, ZA 2333 ,","place":["the 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