{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:47:16Z","timestamp":1787878036047,"version":"build-2784847793"},"reference-count":58,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01AG080516"],"award-info":[{"award-number":["1R01AG080516"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Aging","award":["UL1TR001105"],"award-info":[{"award-number":["UL1TR001105"]}]},{"name":"National Center for Advancing Translational Science, National Institutes of Health"},{"name":"Center for Translational Medicine, The University of Texas Southwestern Medical Center"},{"name":"academic and health care centers"},{"DOI":"10.13039\/100006108","name":"the National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgen-dependent prostate pathology, including prostate cancer and benign prostatic hyperplasia, differs in prevalence and phenotype across races\/ethnicities. Adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) are relevant to several androgen-dependent pathologies, but data on their race\/ethnic variations are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male participants in the multiethnic cross-sectional Dallas Heart Study-2 were included. Serum androstenedione, testosterone, and 11-oxyandrogens were quantified simultaneously using liquid chromatography-tandem mass spectrometry and were compared across races, adjusting for age, body mass index (BMI), and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1025 men (mean age 51 \u00b1 10 years), 478 (47%) were Black, 375 (37%) White, 141 (14%) Hispanic, and 31 (3%) other races. Androgen concentrations varied with race\/ethnicity: testosterone medians (interquartile ranges): 338 (248-465), 347 (287-428), and 307 (232-422) ng\/dL; 11-ketotestosterone: 27 (16-46), 24 (15-41), and 21 (13-36) ng\/dL in Black, Hispanic, and White men, respectively (P &amp;lt; .01 for both). Compared with White men with similar age and BMI, Black men had higher concentrations of testosterone (\u03b2 = 47.06 \u00b1 13.05\u2005ng\/dL), 11-ketotestosterone (\u03b2 = 7.30 \u00b1 1.90\u2005ng\/dL), androstenedione, and 11-oxy-androstenedione, while Hispanic men had higher 11-ketoandrostenedione and 11-ketotestosterone (P &amp;lt; .05 for all). Race- and age-adjusted concentrations of testosterone and androstenedione decreased with BMI, whereas all 11-oxyandrogens increased with BMI (P &amp;lt; .05). After adjusting for race and BMI, 11\u03b2-hydroxyandrostenedione increased with age (P &amp;lt; .001), while all other androgens remained stable across ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circulating 11-ketotestosterone concentrations were higher in Black and Hispanic men than in White men with similar age and BMI. Interethnic variability in systemic androgens might contribute to differences in androgen-related pathologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag335","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:13:25Z","timestamp":1786702405000},"source":"Crossref","is-referenced-by-count":1,"title":["Racial and ethnic differences in classic and 11-oxygenated androgens in men"],"prefix":"10.1210","author":[{"given":"Peeradon","family":"Vibhatavata","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]},{"name":"Division of Endocrinology and Metabolism, Faculty of Medicine, Thammasat University , Pathum Thani 12120 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaelin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juilee","family":"Rege","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E","family":"Rainey","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-3474","authenticated-orcid":false,"given":"Nima","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL 33136 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Auchus","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-6190","authenticated-orcid":false,"given":"Adina F","family":"Turcu","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"6","key":"2026082709370839100_dgag335-B1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/UPJ.0000000000000859","article-title":"Racial differences in benign prostatic hyperplasia diagnosis and management in the United States veteran population","volume":"12","author":"Tram","year":"2025","journal-title":"Urol Pract"},{"issue":"2","key":"2026082709370839100_dgag335-B2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5534\/wjmh.210070","article-title":"Racial differences in prostate cancer characteristics and cancer-specific mortality: an overview","volume":"40","author":"Hinata","year":"2022","journal-title":"World J Mens Health"},{"issue":"2","key":"2026082709370839100_dgag335-B3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0039-128X(92)90032-5","article-title":"Racial\/ethnic variations in male testosterone levels: a probable contributor to group differences in health","volume":"57","author":"Ellis","year":"1992","journal-title":"Steroids"},{"issue":"1","key":"2026082709370839100_dgag335-B4","first-page":"45","article-title":"Serum testosterone levels in healthy young black and white men","volume":"76","author":"Ross","year":"1986","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"2026082709370839100_dgag335-B5","first-page":"1041","article-title":"Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. 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