{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:05:03Z","timestamp":1789477503303,"version":"build-2803163510"},"reference-count":28,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012264","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23 DK136931"],"award-info":[{"award-number":["K23 DK136931"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Approximately 20% of patients with chronic pancreatitis achieve insulin independence one year after total pancreatectomy with islet autotransplantation (TPIAT), an outcome associated with younger age and lower pretransplant glycated hemoglobin A1c (HbA1c). The contribution of diabetes-related genetics to TPIAT outcomes is unknown. Genetic risk scores (GRS) are associated with C-peptide levels in type 1 (T1D) and type 2 (T2D) diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to evaluate whether T1D and T2D GRS and partitioned metabolic polygenic scores (PGS) are associated with diabetes before TPIAT and metabolic outcomes 1 year after transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We genotyped 318 patients with chronic pancreatitis undergoing TPIAT in the multicenter Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIAT using a global screening array. Regression models assessed associations of T1D- and T2D-GRS and metabolic PGS with diabetes outcomes 1 year after TPIAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants were ages 29 \u00b1 17 years, 61% female, 84% non-Hispanic White, and 13% had diabetes prior to transplant. T2D-GRS was higher among those with pre-TPIAT diabetes (\u22120.6 \u00b1 0.3 vs \u22120.8 \u00b1 0.2; P = .003) and was associated with higher pretransplant HbA1c (\u03b2 = 0.19% per 1 SD [95% CI, 0.04-0.33]; P = 0.011). Adjusted for genotype-derived ancestry and islet equivalents\/kg, the \u03b2-cell PGS was associated with higher insulin dose (\u03b2=0.05 units\/kg\/day per 1 SD [95% CI, 0.01-0.09]; P = .016) and higher insulin dose\u2013adjusted A1c (IDAA1c) (\u03b2 = 0.34 [95% CI, 0.03-0.67]; P = .029) 1 year post transplant. The lipodystrophy PGS was associated with higher IDAA1c (\u03b2 = 0.38 [95% CI, 0.06-0.69]; P = .019) and lower fasting C-peptide (\u03b2 = \u22120.09 [95% CI, \u20130.18 to 0]; P = .041) at 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T2D genetic risk is associated with diabetes prior to TPIAT, and \u03b2-cell and lipodystrophy PGS are associated with post-TPIAT diabetes outcomes. Diabetes-related genetics may influence transplantation outcomes and inform metabolic heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag355","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:22:16Z","timestamp":1788520936000},"source":"Crossref","is-referenced-by-count":0,"title":["Diabetes-related genetics and outcomes after total pancreatectomy with islet autotransplantation"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-6542","authenticated-orcid":false,"given":"Taylor M","family":"Triolo","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-9745","authenticated-orcid":false,"given":"Anne A","family":"Eaton","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Health Data Science, University of Minnesota School of Public Health , Minneapolis, MN 55414 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Virginia School of Medicine , Charlottesville, VA 22908 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-6673","authenticated-orcid":false,"given":"Piotr","family":"Witkowski","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Chicago , Chicago, IL 60637 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu-El-Haija","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center , Cincinnati, OH 45229 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A","family":"Ahmad","sequence":"additional","affiliation":[{"name":"University of Cincinnati Department of Surgery, , Cincinnati, OH 45221 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Prakash","family":"Mokshagundam","sequence":"additional","affiliation":[{"name":"University of Louisville Department of Medicine, , Louisville, KY 40292 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-1478","authenticated-orcid":false,"given":"Martin","family":"Wijkstrom","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Department of Surgery, , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-9572","authenticated-orcid":false,"given":"Bashoo","family":"Naziruddin","sequence":"additional","affiliation":[{"name":"Baylor Simmons Transplant Institute , Dallas, TX 75246 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-3521","authenticated-orcid":false,"given":"Vikesh K","family":"Singh","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medical Institutions Division of Gastroenterology, , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Posselt","sequence":"additional","affiliation":[{"name":"University of California at San Francisco Department of Surgery, , San Francisco, CA 94143 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-3326","authenticated-orcid":false,"given":"Jaimie D","family":"Nathan","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital Department of Pediatric Abdominal Transplant and Hepatopancreatobiliary Surgery, , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Morgan","sequence":"additional","affiliation":[{"name":"NYU Langone Health , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F","family":"Lara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, University of Cincinnati Medical Center, Cincinnati, OH 45221 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B","family":"Gardner","sequence":"additional","affiliation":[{"name":"Dartmouth-Hitchcock Medical Center Section of Gastroenterology and Hepatology, Department of Medicine, , , NH 03756,","place":["Lebanon USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-8334","authenticated-orcid":false,"given":"Suna","family":"Onengut-Gumuscu","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Virginia School of Medicine , Charlottesville, VA 22908 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-9484","authenticated-orcid":false,"given":"Andrea K","family":"Steck","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 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