{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:06Z","timestamp":1792788546058,"version":"4.5.0"},"reference-count":42,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["003341121"],"award-info":[{"award-number":["003341121"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Vaincre La Mucoviscidose","award":["RC20230503228\/1\/1\/240"],"award-info":[{"award-number":["RC20230503228\/1\/1\/240"]}],"id":[{"id":"https:\/\/ror.org\/00gp9bw49","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Glucose tolerance abnormalities can be detected in preschool and school-age children with cystic fibrosis (CF). There are limited data on the impact of CF transmembrane conductance regulator modulator elexacaftor\/tezacaftor\/ivacaftor (ETI) on their trajectories. We examined continuous glucose monitoring (CGM) metrics before and after ETI initiation across different pediatric age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included participants from the French MODUL-CF real-world study, ages 2 to 18 years, with at least 24\u2005hours of CGM data before initiation of ETI and a second CGM 12 \u00b1 3 months following ETI start. The cohort was stratified into 3 groups based on the age at ETI initiation: &amp;lt;6, 6 to 12, and &amp;gt;12 years. CGM-derived glucose metrics were compared before and after ETI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-eight patients with CF were enrolled, including 13 preschool children, 54 school-age children, and 31 adolescents. At baseline, participants displayed a time in tight glucose range (TITR) of 89.8% (interquartile range [IQR], 84.1% to 93.4%) with 35% of the whole cohort spending &amp;gt;10% of time &amp;gt;140\u2005mg\/dL (TA140). Following treatment, TITR increased by 1.8% (IQR, \u22121.8% to 6.0%; P = .004). This was associated with a 0.4% reduction in mild hyperglycemia (&amp;gt;140\u2005mg\/dL) and a lower coefficient of variation (21.5% [IQR, 19.0% to 24.7%] vs 19.6% [IQR, 17.0% to 22.6%]; P &amp;lt; .001). Those with TA140 \u2264 10% at baseline displayed greater weight gain and improvement of lung function with respect to the group with TA140 &amp;gt; 10%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ETI is associated with improvement of CGM glucose in children and adolescents with CF. TA140 before ETI initiation may impact the trajectory of clinically relevant outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag358","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:07:38Z","timestamp":1788178058000},"source":"Crossref","is-referenced-by-count":0,"title":["Continuous glucose monitoring to track metabolic changes in youths with cystic fibrosis before and after initiation of elexacaftor\/tezacaftor\/ivacaftor therapy"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-3056","authenticated-orcid":false,"given":"Alfonso","family":"Galderisi","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology and Diabetes Service-H\u00f4pital Universitaire Robert-Debr\u00e9, Universit\u00e9 Paris Cite , Paris 75019 ,","place":["France"]},{"name":"Department of Pediatrics, Yale University , New Haven, CT 06510 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