{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:45:08Z","timestamp":1792640708803,"version":"4.5.0"},"reference-count":22,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DPVD randomized"},{"DOI":"10.13039\/100030790","name":"Kitakyushu Medical Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030790","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["25K14421"],"award-info":[{"award-number":["25K14421"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Active vitamin D analogs increase bone mineral density (BMD), but interindividual variability in skeletal response remains unexplained. Emerging evidence suggests that skeletal remodeling is influenced by systemic metabolic status. Therefore, we examined whether metabolic state, defined by glycemic trajectory, modifies skeletal responsiveness to eldecalcitol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc cohort analysis used data from the Diabetes Prevention with Vitamin D randomized, placebo-controlled trial. Among 1256 individuals with prediabetes, 1164 participants with longitudinal BMD measurements were included. Longitudinal changes in lumbar spine BMD over 3 years were analyzed using a linear mixed-effects model, including treatment group, glycemic trajectory (incident type 2 diabetes, persistent prediabetes, or regression to normoglycemia), time, and their interaction terms. Multivariable linear regression was used to identify baseline factors associated with the 3-year percentage change in lumbar spine BMD in the eldecalcitol group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lumbar spine BMD trajectories differed according to treatment assignment and glycemic trajectory (treatment-by-trajectory-by-time interaction, P = .0307). Among participants receiving eldecalcitol, 3-year BMD increases were progressively greater with more favorable glycemic trajectories (4.6% in those who progressed to type 2 diabetes, 7.3% in those with persistent prediabetes, and 9.2% in those who regressed to normoglycemia; trajectory-by-time interaction, P = .0098), whereas no significant differences across glycemic trajectories were observed in the placebo group (P = .772). In addition, a lower baseline HbA1c was independently associated with a greater 3-year increase in lumbar spine BMD (\u03b2 = \u22125.15 percentage points per 1% higher HbA1c; 95% CI, \u22128.34 to \u22121.95; P = .002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that metabolic status influences skeletal response to active vitamin D therapy and support the concept of bone\u2013metabolic coupling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag396","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:26:14Z","timestamp":1790425574000},"source":"Crossref","is-referenced-by-count":1,"title":["Metabolic status modifies skeletal response to active vitamin D: a post hoc analysis of the Diabetes Prevention with Vitamin D (DPVD) randomized trial"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-4871","authenticated-orcid":false,"given":"Tetsuya","family":"Kawahara","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Occupational and Environmental Health , Kitakyushu 807-8555 ,","place":["Japan"]},{"name":"Department of Endocrinology and Metabolism, Shinkomonji Hospital , Kitakyushu 800-0057 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shinkomonji Hospital , Kitakyushu 800-0057 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Kanagawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Shinkomonji Hospital , Kitakyushu 800-0057 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagahiro","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Shinkomonji Hospital , Kitakyushu 800-0057 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Honaigo Medical Clinic , Kujigun 319-3526 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Inazu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmaceutical Science, Ritsumeikan University , Kusatsu 525-8527 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Occupational and Environmental Health , Kitakyushu 807-8555 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