{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:55:38Z","timestamp":1791478538238,"version":"4.3.4"},"reference-count":49,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Fatty pancreas is associated with obesity and metabolic alterations and may coexist with pancreatic structural remodeling. However, its contribution to \u03b2-cell dysfunction remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the relationship between pancreatic fat, tissue remodeling, and \u03b2-cell function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study in individuals with ultrasound-detected pancreatic hyperechogenicity without prior diagnosis of diabetes. Pancreatic fat was quantified by magnetic resonance imaging (MRI)-derived proton density fat fraction, while tissue stiffness was assessed by shear wave elastography. Metabolic phenotyping was based on oral glucose tolerance test (OGTT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>We recruited 29 individuals with ultrasound-detected fatty pancreas (F\/M 16\/13, age 54 \u00b1 10.4 years) and assessed glucose tolerance with OGTT: 75.9% exhibited normal glucose tolerance (n = 22), while 24.1% had impaired glucose tolerance (n = 7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MRI-derived pancreatic fat fraction was positively correlated with anthropometric measures (body mass index \u03c1 = 0.43, P = .02) and \u03b2-cell function (\u03b2-cell glucose sensitivity \u03c1 = 0.40, P = .03). Pancreatic stiffness correlated negatively with body weight (\u03c1 = \u22120.38, P = .04), did not correlate with pancreatic fat fraction (\u03c1 = \u22120.15, P = .44), and was correlated inversely with the potentiation factor ratio 1 (\u03c1 = \u22120.44, P = .02), a measure of non\u2013glucose-dependent amplification of insulin secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intrapancreatic fat and pancreatic stiffness appear to reflect distinct pathophysiological processes, with potentially different relationships to systemic metabolic status and \u03b2-cell function. These findings support a more nuanced view of pancreatic structural alterations as heterogeneous markers of metabolic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag399","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:33:22Z","timestamp":1790508802000},"source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic fat and stiffness reflect distinct features of pancreatic remodeling and \u03b2-cell function"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3644-8063","authenticated-orcid":false,"given":"Sara Sofia","family":"De Lucia","sequence":"first","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3621-6298","authenticated-orcid":false,"given":"Gea","family":"Ciccarelli","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]},{"name":"Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]},{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1065-6030","authenticated-orcid":false,"given":"Giulia","family":"Gliozzo","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-5193","authenticated-orcid":false,"given":"Gianfranco","family":"Di Giuseppe","sequence":"additional","affiliation":[{"name":"Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Soldovieri","sequence":"additional","affiliation":[{"name":"Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Gentile","sequence":"additional","affiliation":[{"name":"Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4672-2881","authenticated-orcid":false,"given":"Enza","family":"Genco","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnostics, Oncologic Radiotherapy, and Hematology, Abdominopelvic Radiology, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnostics, Oncologic Radiotherapy, and Hematology, Abdominopelvic Radiology, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0814-9542","authenticated-orcid":false,"given":"Maria Assunta","family":"Zocco","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-1065","authenticated-orcid":false,"given":"Maria Elena","family":"Ainora","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8296-168X","authenticated-orcid":false,"given":"Giorgio","family":"Esposto","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sposato","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-1730","authenticated-orcid":false,"given":"Roberto","family":"Bizzotto","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, CNR , Padua 35127 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giaccari","sequence":"additional","affiliation":[{"name":"Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]},{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-6924","authenticated-orcid":false,"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]},{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3668-8906","authenticated-orcid":false,"given":"Enrico Celestino","family":"Nista","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-9576","authenticated-orcid":false,"given":"Teresa","family":"Mezza","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]},{"name":"Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome 00168 ,","place":["Italy"]},{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026100812171068700_dgag399-B1","first-page":"S49","article-title":"Nonalcoholic fatty pancreas disease","volume":"34 Suppl 1","author":"Shah","year":"2019","journal-title":"Nutr Clin Pract"},{"issue":"1","key":"2026100812171068700_dgag399-B2","doi-asserted-by":"crossref","DOI":"10.1002\/ueg2.70185","article-title":"International multidisciplinary consensus report on definitions, diagnostic criteria, and management of fatty pancreas: a joint statement endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG","volume":"14","author":"Vujasinovic","year":"2026","journal-title":"United European Gastroenterol 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