{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:44:51Z","timestamp":1792169091477,"version":"4.4.0"},"reference-count":36,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple endocrine neoplasia type 1 (MEN1) is an uncommon, autosomal dominant inherited endocrine tumor predisposition syndrome. The most common manifestations of MEN1 are primary hyperparathyroidism, pancreatic neuroendocrine tumors, and pituitary adenomas. Individuals with MEN1 benefit from lifelong surveillance, with the aim of detecting MEN1 manifestations early. The ideal time point for interventions needs to be carefully selected in the context of the syndrome. Published guidelines help clinicians to navigate the management and follow-up of individuals with MEN1. This article aims to explore some of the nuance in the investigation and management of this often complex condition from an endocrinologist's point of view, through exploration of 4 clinical case vignettes.<\/jats:p>","DOI":"10.1210\/clinem\/dgag414","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:48:01Z","timestamp":1791632881000},"source":"Crossref","is-referenced-by-count":0,"title":["Approach to the patient with MEN1 syndrome"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1553-0237","authenticated-orcid":false,"given":"Anna L","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne NHS Hospitals Foundation Trust , Newcastle upon Tyne NE1\u00a04LP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4101-9432","authenticated-orcid":false,"given":"M\u00e1rta","family":"Korbonits","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London , London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"issue":"8","key":"2026101611472343100_dgag414-B1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S2213-8587(25)00119-6","article-title":"Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice","volume":"13","author":"Brandi","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2026101611472343100_dgag414-B2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ando.2023.09.003","article-title":"French guidelines from the GTE, AFCE and ENDOCAN-RENATEN (Groupe d'etude des Tumeurs Endocrines\/Association Francophone de Chirurgie Endocrinienne\/Reseau national de prise en charge des tumeurs endocrines) for the screening, diagnosis and management of Multiple Endocrine Neoplasia Type 1","volume":"85","author":"Goudet","year":"2024","journal-title":"Ann Endocrinol (Paris)"},{"issue":"3","key":"2026101611472343100_dgag414-B3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1158\/1078-0432.CCR-0938-3","article-title":"Meningiomas may be a component tumor of multiple endocrine neoplasia type 1","volume":"10","author":"Asgharian","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"6","key":"2026101611472343100_dgag414-B4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMc1406028","article-title":"Breast-cancer predisposition in multiple endocrine neoplasia type 1","volume":"371","author":"Dreijerink","year":"2014","journal-title":"N Engl J Med"},{"issue":"10","key":"2026101611472343100_dgag414-B5","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.celrep.2017.02.025","article-title":"Enhancer-mediated oncogenic function of the menin tumor suppressor in breast cancer","volume":"18","author":"Dreijerink","year":"2017","journal-title":"Cell Rep"},{"issue":"5311","key":"2026101611472343100_dgag414-B6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"issue":"7","key":"2026101611472343100_dgag414-B7","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/6.7.1177","article-title":"Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1","volume":"6","author":"Lemmens","year":"1997","journal-title":"Hum Mol Genet"},{"issue":"6","key":"2026101611472343100_dgag414-B8","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1093\/ejendo\/lvaf247","article-title":"New directions in MEN1 management: navigating the new clinical practice guidelines","volume":"193","author":"Papalou","year":"2025","journal-title":"Eur J Endocrinol"},{"key":"2026101611472343100_dgag414-B9","author":"NHS England"},{"key":"2026101611472343100_dgag414-B10","author":"Durkie"},{"issue":"1","key":"2026101611472343100_dgag414-B11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/pch\/pxab070","article-title":"Understanding genetic variants of uncertain significance","volume":"27","author":"Joynt","year":"2022","journal-title":"Paediatr Child Health"},{"key":"2026101611472343100_dgag414-B12","author":"Association for Multiple Endocrine Neoplasia 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