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collaboration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to assess pancreatic and hepatic steatosis (PS\/HS) association with residual insulin secretion and insulin resistance in individuals with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pancreatic\/liver fat fractions (PFF\/LFF) in magnetic resonance imaging (MRI) were used as a proxy for PS and HS in 170 participants. Insulin secretion was estimated by HOMA2-B, C-peptide response 6\u2005minutes after an intravenous bolus of 0.5\u2005mg glucagon (\u0394C-Pe), and fasting proinsulin to C-peptide ratio (PI:C). Insulin resistance was estimated by HOMA2-IR, Adipo-IR, and intravenous insulin (0.05\u2005IU\/kg) tolerance test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PFF did not correlate with measures of insulin secretion, but it correlated with fasting indices of insulin resistance among women (HOMA2-IR, R = 0.26, P = .017; Adipo-IR, R = 0.29, P = .007). Both LFF and PFF correlated with BMI (R = 0.43 and R = 0.34, respectively, P &amp;lt; .001) but not with each other (R = 0.10, P = .215). Unlike PS, HS was associated with higher HOMA2-IR, Adipo-IR, HOMA2-B, PI:C, and glucagon, after adjustment with confounders. Participants with PS without HS had lower fasting C-peptide, HOMA2-IR, HOMA2-B, Adipo-IR, glucagon, and triglycerides (P &amp;lt; .05) compared to those having HS without PS. Cluster-based subgroups of diabetes did not differ in PF (P = .071).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within this cohort, pancreatic fat was more strongly associated with adiposity than with the investigated measures of \u03b2-cell function or insulin resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag416","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:51:26Z","timestamp":1792065086000},"source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic steatosis is not associated with impaired insulin secretion among individuals with diabetes"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0846-4434","authenticated-orcid":false,"given":"Aleksi","family":"Laitinen","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine Finland and Research Program of Clinical and Molecular Medicine, University of Helsinki , 00290 Helsinki ,","place":["Finland"]},{"name":"Department of Endocrinology, Vaasa Central Hospital, Wellbeing Services Area of Ostrobothnia , 65130 Vaasa ,","place":["Finland"]},{"name":"Department of Endocrinology, Turku University Hospital , 20520 Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-1475","authenticated-orcid":false,"given":"Katarina","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Radiology, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital , 00290 Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-6762","authenticated-orcid":false,"given":"Aki J","family":"K\u00e4r\u00e4j\u00e4m\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Vaasa Central Hospital, Wellbeing Services of County of Ostrobothnia , 65130 Vaasa ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-5611","authenticated-orcid":false,"given":"Annemari","family":"K\u00e4r\u00e4j\u00e4m\u00e4ki","sequence":"additional","affiliation":[{"name":"Diabetes Unit of Ostrobothnia, Wellbeing Services County of Ostrobothnia , 65100 Vaasa ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"H\u00e4ggblom","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery, Vaasa Central Hospital, Wellbeing Services of County of Ostrobothnia , 65130 Vaasa ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-3873","authenticated-orcid":false,"given":"Liisa","family":"Hakaste","sequence":"additional","affiliation":[{"name":"Institute for Molecular 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