{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:39:02Z","timestamp":1792575542645,"version":"4.5.0"},"reference-count":0,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Bariatric metabolic surgery has potent effects on glucose metabolism, with increases in insulin sensitivity and insulin secretion contributing to both improved glycemia and\/or remission of type 2 diabetes (T2D) and development of hypoglycemia (post-bariatric hypoglycemia, PBH). Previous studies suggest GH secretion and\/or action are altered after bariatric surgery and may mediate early post-surgical improvements in glycemic control. Given the importance of GH signaling in glucose metabolism, we hypothesized that reductions in GH signaling and\/or action could also contribute to PBH.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n Assessment of GH responses to two distinct stimuli: (1) experimental hypoglycemia induced by hyperinsulinemic hypoglycemic clamp and (2) glucagon stimulation.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Academic medical center<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS<\/jats:title>\n Individuals with history of Roux-en-Y gastric bypass (RYGB) with PBH (n=20), without hypoglycemia (n=20), and weight-matched non-surgical controls (n=10).<\/jats:p>\n <\/jats:sec>\n \n Main outcomes<\/jats:title>\n GH responses were assessed (1) during experimental hypoglycemia and (2) after glucagon stimulation. Plasma GH receptor (GHR) and insulin-like growth factors and binding proteins were also measured.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Glucagon-stimulated GH levels were 5\u20136 times higher in both post-RYGB groups vs. controls at 120 minutes: control: 481\u00b1137 pg\/ml; RYGB non-hypo 2521 \u00b1 678 pg\/ml; PBH: 3018 \u00b1137pg\/ml (control vs RYGB non-hypo p=0.02; control vs PBH; p=0.005). In contrast, PBH participants showed lower GH responses to experimental hypoglycemia. Additionally, plasma GHR and IGF-1 levels were reduced in PBH vs. controls.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We find that plasma GH response to 2 distinct experimental stimuli differed in participants with a history of bariatric surgery. However, these patterns did not differ in those with and without PBH. Further studies will be required to determine if tissue-level alterations in GH action contribute to improved glycemic control after bariatric surgery.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/clinem\/dgag428","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:41:26Z","timestamp":1792496486000},"source":"Crossref","is-referenced-by-count":0,"title":["Dysregulation of Growth Hormone Axis after Roux-en-Y Gastric Bypass"],"prefix":"10.1210","author":[{"given":"Lei","family":"Pei","sequence":"first","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Cummings","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamayle","family":"Saeed","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Amore","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Farahmandsadr","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ferraz-Bannitz","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C","family":"Simonson","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston MA"},{"name":"Division of Endocrinology, Diabetes and Hypertension; Brigham and Women\u2019s Hospital , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-3429","authenticated-orcid":false,"given":"Mary-Elizabeth","family":"Patti","sequence":"additional","affiliation":[{"name":"Research Division, Joslin Diabetes Center , Boston, MA"},{"name":"Harvard Medical School , Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,10,21]]},"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag428\/72208134\/dgag428.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgag428\/72208134\/dgag428.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:41:03Z","timestamp":1792572063000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article\/doi\/10.1210\/clinem\/dgag428\/8957486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgag428","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"article-number":"dgag428"}}