{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:04:20Z","timestamp":1786489460080,"version":"build-2736575974"},"reference-count":85,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Human reproduction is mainly governed from the hypothalamic\u2013adrenal\u2013gonadal (HPG) axis, which controls both ovarian morphology and function. Disturbances in the secretion of other anterior pituitary hormones (and their respective endocrine axes) interfere with HPG activity and have been linked to fertility problems. In normal pregnancy, maintenance of homeostasis is associated with continuous changes in pituitary morphology and function, which need to be considered during hormone replacement in patients with hypopituitarism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We conducted a systematic PubMed literature review from 1969 to 2019, with the following keywords: fertility and hypopituitarism, pregnancy and hypopituitarism, and ovulation induction and hypopituitarism. Case reports or single-case series of up to 2 patients\/4 pregnancies were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven publications described data on fertility (n = 6) and\/or pregnancy (n = 7) in women with hypopituitarism. Women with hypopituitarism often need assisted reproductive treatment, with pregnancy rates ranging from 47% to 100%. In patients achieving pregnancy, live birth rate ranged from 61% to 100%. While glucocorticoids, levothyroxine, and desmopressin are safely prescribed during pregnancy, growth hormone treatment regimens vary significantly between countries, and several publications support a positive effect in women seeking fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this first systematic review on fertility, ovulation induction, and pregnancy in patients with hypopituitarism, we show that while literature is scarce, birth rates are high in patients achieving pregnancy. However, prospective studies are needed for evaluating outcomes in relationship to treatment patterns. Replacement therapy in hypopituitarism should always mimic normal physiology, and this becomes challenging with changing demands during pregnancy evolution.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgz112","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T20:32:32Z","timestamp":1572035552000},"page":"e53-e65","source":"Crossref","is-referenced-by-count":46,"title":["Fertility and Pregnancy in Women With Hypopituitarism: A Systematic Literature Review"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-1959","authenticated-orcid":false,"given":"Greisa","family":"Vila","sequence":"first","affiliation":[{"name":"Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, 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\u201cclonidine-negative\u201d patients with unexplained infertility","volume":"626","author":"Blumenfeld","year":"1991","journal-title":"Ann N Y Acad Sci."},{"issue":"2","key":"2021122017515013700_CIT0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/oxfordjournals.humrep.a138483","article-title":"Growth hormone co-treatment for ovulation induction may enhance conception in the co-treatment and succeeding cycles, in clonidine negative but not clonidine positive patients","volume":"9","author":"Blumenfeld","year":"1994","journal-title":"Hum Reprod."},{"issue":"6 Pt 1","key":"2021122017515013700_CIT0036","first-page":"E1014","article-title":"Placental growth hormone as a potential regulator of maternal IGF-I during human pregnancy","volume":"258","author":"Caufriez","year":"1990","journal-title":"Am J Physiol."},{"issue":"2","key":"2021122017515013700_CIT0037","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1210\/jcem-71-2-520","article-title":"Perinatal 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Steril."},{"key":"2021122017515013700_CIT0050","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/humrep\/8.suppl_2.184","article-title":"Pulsatile administration of gonadotrophin releasing hormone and oral administration of naltrexone in hypothalamic amenorrhoea","volume":"8","author":"Leyendecker","year":"1993","journal-title":"Hum Reprod."},{"issue":"4","key":"2021122017515013700_CIT0051","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0015-0282(16)46573-8","article-title":"Partial hypopituitarism and hyperprolactinemia: successful induction of ovulation with bromocriptine and human menopausal gonadotropins","volume":"38","author":"Dawood","year":"1982","journal-title":"Fertil Steril."},{"issue":"1","key":"2021122017515013700_CIT0052","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1507\/endocrj.K10E-208","article-title":"Successful pregnancy and delivery in a patient with adult GH deficiency: role of GH replacement 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