{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:58:36Z","timestamp":1791853116934,"version":"4.3.4"},"reference-count":48,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is a common disorder characterized by upper airway collapse requiring nocturnal ventilatory assistance. Multiple studies have investigated the relationship between acromegaly and OSA, reporting discordant results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To conduct a meta-analysis on the risk for OSA in acromegaly, and in particular to assess the role of disease activity and the effect of treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Study Selection<\/jats:title>\n                    <jats:p>A search through literature databases retrieved 21 articles for a total of 24 studies (n = 734). Selected outcomes were OSA prevalence and apnea-hypopnea index (AHI) in studies comparing acromegalic patients with active (ACT) vs inactive (INACT) disease and pretreatment and posttreatment measures. Factors used for moderator and meta-regression analysis included the percentage of patients with severe OSA, patient sex, age, body mass index, levels of insulin-like growth factor 1, disease duration and follow-up, and therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>OSA prevalence was similar in patients with acromegaly who had ACT and INACT disease (ES = \u22120.16; 95% CI, \u22120.47 to 0.15; number of studies [k] = 10; P = 0.32). In addition, AHI was similar in ACT and INACT acromegaly patients (ES = \u22120.03; 95% CI, \u22120.49 to 0.43; k = 6; P = 0.89). When AHI was compared before and after treatment in patients with acromegaly (median follow-up of 6 months), a significant improvement was observed after treatment (ES = \u22120.36; 95% CI, \u22120.49 to \u22120.23; k = 10; P &amp;lt; 0.0001). In moderator analysis, the percentage of patients with severe OSA in the populations significantly influenced the difference in OSA prevalence (P = 0.038) and AHI (P = 0.04) in ACT vs INACT patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prevalence of OSA and AHI is similar in ACT and INACT patients in cross-sectional studies. However, when AHI was measured longitudinally before and after treatment, a significant improvement was observed after treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgz116","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T16:32:34Z","timestamp":1573662754000},"page":"e23-e31","source":"Crossref","is-referenced-by-count":47,"title":["Obstructive Sleep Apnea in Acromegaly and the Effect of Treatment: A Systematic Review and Meta-Analysis"],"prefix":"10.1210","volume":"105","author":[{"given":"Matteo","family":"Parolin","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"},{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dassie","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"},{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Alessio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Wennberg","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rossato","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"},{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Vettor","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"},{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Maffei","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"},{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4335-8411","authenticated-orcid":false,"given":"Claudio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Padua, via Giustiniani 2, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"issue":"11","key":"2021122102022198600_CIT0001","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1172\/JCI39375","article-title":"Acromegaly pathogenesis and treatment","volume":"119","author":"Melmed","year":"2009","journal-title":"J Clin Invest."},{"issue":"24","key":"2021122102022198600_CIT0002","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: Acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N Engl J Med."},{"issue":"1","key":"2021122102022198600_CIT0003","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11102-017-0797-7","article-title":"Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities","volume":"20","author":"Pivonello","year":"2017","journal-title":"Pituitary."},{"issue":"1","key":"2021122102022198600_CIT0004","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/er.2002-0022","article-title":"Systemic complications of acromegaly: epidemiology, pathogenesis, and management","volume":"25","author":"Colao","year":"2004","journal-title":"Endocr Rev."},{"issue":"188","key":"2021122102022198600_CIT0005","first-page":"517","article-title":"Lung function in acromegaly","volume":"47","author":"Harrison","year":"1978","journal-title":"Q J Med."},{"issue":"7","key":"2021122102022198600_CIT0006","doi-asserted-by":"crossref","first-page":"527","DOI":"10.7326\/0003-4819-115-7-527","article-title":"Sleep apnea in acromegaly","volume":"115","author":"Grunstein","year":"1991","journal-title":"Ann Intern Med."},{"issue":"6218","key":"2021122102022198600_CIT0007","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.280.6218.894","article-title":"Sleep apnoea in acromegaly","volume":"280","author":"Perks","year":"1980","journal-title":"Br Med J."},{"issue":"7","key":"2021122102022198600_CIT0008","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1056\/NEJMcp012849","article-title":"Clinical practice. 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