{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:33:49Z","timestamp":1790822029215,"version":"4.1.0"},"reference-count":46,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministero Dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","award":["2015JHLY35"],"award-info":[{"award-number":["2015JHLY35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>There is little information on cognitive function in Silver\u2013Russell syndrome (SRS), and no neuroimaging studies are available so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess cognitive function and brain volumes in patients with SRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Setting<\/jats:title><jats:p>Wechsler Intelligence Scale and brain magnetic resonance on a 3-Tesla scanner with Voxel-based morphometry analysis were performed between 2016 and 2018 in a single tertiary university center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Partecipants<\/jats:title><jats:p>38 white subjects with clinical diagnosis of SRS confirmed by molecular analysis: 30 of these patients (mean age 12.6 \u00b1 10 years) were enrolled for cognitive assessment; 23 of the 30 performed neuroimaging sequences. A control group of 33 school-aged children performed cognitive assessment while 65 age and sex-matched volunteers were included for the neuroradiological assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcomes<\/jats:title><jats:p>Intelligence quotient, Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI), Processing Speed Index, and brain volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean overall IQ score was 87.2 \u00b1 17, and it was significantly lower in the maternal uniparental disomy of chromosome 7 (mUPD7) group at the age of 6 to 16 years compared to loss of methylation on chromosome 11p15 (11p15 LOM) group and to controls. VCI, PRI, and WMI were significantly higher in 11p15 LOM group and in control group than in mUPD7 group at the age of 6 to 16 years. There were no significant differences in cognitive scores between 11p15 LOM school-aged patients and the control group. SRS patients showed lower brain volume compared to controls at the frontal\/temporal poles and globi pallidi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with mUPD7 had an impaired cognitive profile. The brain volume at the frontal\/temporal lobes and at the globi pallidi was reduced in patients with SRS.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgz151","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T18:31:29Z","timestamp":1572460289000},"page":"e1478-e1488","source":"Crossref","is-referenced-by-count":7,"title":["Cognitive Profiles and Brain Volume Are Affected in Patients with Silver\u2013Russell Syndrome"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-1919","authenticated-orcid":false,"given":"Giuseppa","family":"Patti","sequence":"first","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"De Mori","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Tortora","sequence":"additional","affiliation":[{"name":"Pediatric Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariasavina","family":"Severino","sequence":"additional","affiliation":[{"name":"Pediatric Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Calevo","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Russo","sequence":"additional","affiliation":[{"name":"Cytogenetic and Molecular Genetics Laboratory, Istituto Auxologico Italiano, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Confalonieri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan F","family":"Thiabat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Casalini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Morana","sequence":"additional","affiliation":[{"name":"Pediatric Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Pediatric Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Antonio","family":"Ramenghi","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Maghnie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascia","family":"Di Iorgi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"issue":"12","key":"2021122209575316300_CIT0001","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1136\/adc.2010.190165","article-title":"Silver\u2013Russell syndrome","volume":"96","author":"Wakeling","year":"2011","journal-title":"Arch Dis Child."},{"issue":"2","key":"2021122209575316300_CIT0002","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrendo.2016.138","article-title":"Diagnosis and management of Silver\u2013Russell syndrome: first international consensus statement","volume":"13","author":"Wakeling","year":"2017","journal-title":"Nat Rev Endocrinol."},{"key":"2021122209575316300_CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcp.2018.12.007","article-title":"Next generation sequencing and imprinting disorders: current applications and future perspectives: lessons from Silver\u2013Russell syndrome","volume":"44","author":"Neuheuser","year":"2019","journal-title":"Mol Cell Probes."},{"issue":"2","key":"2021122209575316300_CIT0004","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/gim.2017.105","article-title":"Genetic disruption of the oncogenic HMGA2-PLAG1-IGF2 pathway causes fetal growth restriction","volume":"20","author":"Abi Habib","year":"2018","journal-title":"Genet Med."},{"issue":"7","key":"2021122209575316300_CIT0005","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1210\/jc.2017-02152","article-title":"Chromosome 14q32.2 imprinted region disruption as an alternative molecular diagnosis of Silver\u2013Russell syndrome","volume":"103","author":"Geoffron","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021122209575316300_CIT0006","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/ajmg.a.33398","article-title":"Chromosome 11p15 duplication in Silver\u2013Russell syndrome due to a maternally inherited translocation t(11;15)","volume":"152A","author":"Eggermann","year":"2010","journal-title":"Am J Med Genet A."},{"issue":"3","key":"2021122209575316300_CIT0007","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000437061","article-title":"Familial 1.3-Mb 11p15.5p15.4 duplication in three generations causing Silver\u2013Russell and Beckwith\u2013Wiedemann Syndromes","volume":"6","author":"Vals","year":"2015","journal-title":"Mol Syndromol."},{"issue":"7","key":"2021122209575316300_CIT0008","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jmedgenet-2014-102979","article-title":"A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver\u2013Russell syndrome","volume":"52","author":"Azzi","year":"2015","journal-title":"J Med Genet."},{"issue":"6","key":"2021122209575316300_CIT0009","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/adc.71.6.490","article-title":"Cognitive abilities associated with the Silver\u2013Russell syndrome","volume":"71","author":"Lai","year":"1994","journal-title":"Arch Dis Child."},{"issue":"5","key":"2021122209575316300_CIT0010","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1469-8749.2004.tb00495.x","article-title":"Cognitive development in Silver\u2013Russell syndrome: a sibling-controlled study","volume":"46","author":"Noeker","year":"2004","journal-title":"Dev Med Child Neurol."},{"issue":"7","key":"2021122209575316300_CIT0011","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1073\/pnas.1019726108","article-title":"The vulnerable developing brain","volume":"108","author":"Giussani","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021122209575316300_CIT0012","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1515\/jpm-2013-0128","article-title":"Cerebroplacental doppler ratio and placental histopathological features in pregnancies complicated by fetal growth restriction","volume":"42","author":"Spinillo","year":"2014","journal-title":"J Perinat Med."},{"issue":"1","key":"2021122209575316300_CIT0013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000020969","article-title":"Intrauterine growth retardation and fetal cardiac function","volume":"15","author":"Severi","year":"2000","journal-title":"Fetal Diagn Ther."},{"issue":"4","key":"2021122209575316300_CIT0014","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000438451","article-title":"Brain-sparing in intrauterine growth restriction: considerations for the neonatologist","volume":"108","author":"Cohen","year":"2015","journal-title":"Neonatology."},{"issue":"10","key":"2021122209575316300_CIT0015","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/aje\/kwn233","article-title":"What is spared by fetal brain-sparing? Fetal circulatory redistribution and behavioral problems in the general population","volume":"168","author":"Roza","year":"2008","journal-title":"Am J Epidemiol."},{"issue":"4","key":"2021122209575316300_CIT0016","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J Physiol."},{"issue":"5","key":"2021122209575316300_CIT0017","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/1933719110388847","article-title":"Cerebral maturation in IUGR and appropriate for gestational age preterm babies","volume":"18","author":"Ramenghi","year":"2011","journal-title":"Reprod Sci."},{"issue":"3","key":"2021122209575316300_CIT0018","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1530\/EJE-11-0964","article-title":"Post-receptor IGF1 insensitivity restricted to the MAPK pathway in a Silver\u2013Russell syndrome patient with hypomethylation at the imprinting control region on chromosome 11","volume":"166","author":"Montenegro","year":"2012","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"2021122209575316300_CIT0019","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2337\/db11-1300","article-title":"The critical role of metabolic pathways in aging","volume":"61","author":"Barzilai","year":"2012","journal-title":"Diabetes."},{"key":"2021122209575316300_CIT0020","doi-asserted-by":"crossref","first-page":"1178626419842176","DOI":"10.1177\/1178626419842176","article-title":"The role of insulin-like growth factors and insulin-like growth factor-binding proteins in the nervous system","volume":"12","author":"Lewitt","year":"2019","journal-title":"Biochem Insights."},{"issue":"1","key":"2021122209575316300_CIT0021","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1073\/pnas.85.1.265","article-title":"Differential expression of insulin-like growth factor genes in rat central nervous system","volume":"85","author":"Rotwein","year":"1988","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021122209575316300_CIT0022","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.yfrne.2012.06.002","article-title":"Neurodevelopmental effects of insulin-like growth factor signaling","volume":"33","author":"O\u2019Kusky","year":"2012","journal-title":"Front Neuroendocrinol."},{"issue":"9","key":"2021122209575316300_CIT0023","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1210\/mend-4-9-1386","article-title":"Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression","volume":"4","author":"Bondy","year":"1990","journal-title":"Mol Endocrinol."},{"issue":"5","key":"2021122209575316300_CIT0024","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1210\/endo.135.5.7525251","article-title":"Insulin-like growth factors cross the blood-brain barrier","volume":"135","author":"Reinhardt","year":"1994","journal-title":"Endocrinology."},{"issue":"1","key":"2021122209575316300_CIT0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/edrv.22.1.0419","article-title":"The somatomedin hypothesis: 2001","volume":"22","author":"Le Roith","year":"2001","journal-title":"Endocr Rev."},{"issue":"Pt 1","key":"2021122209575316300_CIT0026","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/brain\/awr305","article-title":"Effect of growth hormone deficiency on brain structure, motor function and cognition","volume":"135","author":"Webb","year":"2012","journal-title":"Brain."},{"key":"2021122209575316300_CIT0027","first-page":"8","article-title":"A multi-method approach to the molecular diagnosis of overt and borderline 11p15.5 defects underlying Silver\u2013Russell and Beckwith-Wiedemann syndromes","author":"Russo","year":"2016","journal-title":"Clin Epigenetics"},{"key":"2021122209575316300_CIT0028","volume-title":"Wechsler Preschool and Primary Scale of Intelligence.","author":"Wechsler","year":"2003","edition":"3"},{"issue":"6","key":"2021122209575316300_CIT0029","first-page":"2225","article-title":"Clinical manifestations and metabolic outcomes of seven adults with Silver\u2013Russell syndrome","volume":"103","author":"Patti","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021122209575316300_CIT0030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-3476(99)70089-2","article-title":"Patterns of cognitive functioning in school-aged children with Noonan syndrome associated with variability in phenotypic expression","volume":"135","author":"van der Burgt","year":"1999","journal-title":"J Pediatr."},{"issue":"5","key":"2021122209575316300_CIT0031","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1086\/508902","article-title":"Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia","volume":"79","author":"Feuk","year":"2006","journal-title":"Am J Hum Genet."},{"key":"2021122209575316300_CIT0032","first-page":"1","article-title":"Intellectual functioning in Silver\u2013Russell syndrome: first study in adults","author":"Burgevin","year":"2019","journal-title":"Appl Neuropsychol Adult"},{"key":"2021122209575316300_CIT0033","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2019.01.012","article-title":"Predicting text reading skills at age 8\u202fyears in children born preterm and at term","volume":"130","author":"Borchers","year":"2019","journal-title":"Early Hum Dev."},{"issue":"1","key":"2021122209575316300_CIT0034","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrendo.2016.127","article-title":"Long-term metabolic risk among children born premature or small for gestational age","volume":"13","author":"Mericq","year":"2017","journal-title":"Nat Rev Endocrinol."},{"key":"2021122209575316300_CIT0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jpeds.2017.04.018","article-title":"Targeted next generation sequencing approach in patients referred for Silver\u2013Russell syndrome testing increases the mutation detection rate and provides decisive information for clinical management","volume":"187","author":"Meyer","year":"2017","journal-title":"J Pediatr."},{"issue":"18","key":"2021122209575316300_CIT0036","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJM199610313351805","article-title":"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene","volume":"335","author":"Woods","year":"1996","journal-title":"N Engl J Med."},{"issue":"3","key":"2021122209575316300_CIT0037","first-page":"113","article-title":"IGF1R mutation analysis in short children with Silver\u2013Russell syndrome features","volume":"2","author":"Soellner","year":"2013","journal-title":"J Pediatr Genet."},{"key":"2021122209575316300_CIT0038","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2016.03.056","article-title":"The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity","volume":"325","author":"Dyer","year":"2016","journal-title":"Neuroscience."},{"issue":"3","key":"2021122209575316300_CIT0039","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0306-4522(98)00143-2","article-title":"Insulin-like growth factor-1 ameliorates age-related behavioral deficits","volume":"87","author":"Markowska","year":"1998","journal-title":"Neuroscience."},{"issue":"4","key":"2021122209575316300_CIT0040","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0306-4522(01)00378-5","article-title":"Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis","volume":"107","author":"Lichtenwalner","year":"2001","journal-title":"Neuroscience."},{"issue":"2","key":"2021122209575316300_CIT0041","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/GCO.0b013e32835e0e9c","article-title":"Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction","volume":"25","author":"Hernandez-Andrade","year":"2013","journal-title":"Curr Opin Obstet Gynecol."},{"issue":"5","key":"2021122209575316300_CIT0042","doi-asserted-by":"crossref","first-page":"474.e1","DOI":"10.1016\/j.ajog.2009.05.028","article-title":"Cerebral blood perfusion and neurobehavioral performance in full-term small-for-gestational-age fetuses","volume":"201","author":"Cruz-Martinez","year":"2009","journal-title":"Am J Obstet Gynecol."},{"issue":"5","key":"2021122209575316300_CIT0043","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.braindev.2013.06.006","article-title":"Comparison of changes in cerebral and systemic perfusion between appropriate- and small-for-gestational-age infants during the first three days after birth","volume":"36","author":"Ishii","year":"2014","journal-title":"Brain Dev."},{"key":"2021122209575316300_CIT0044","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fnins.2016.00560","article-title":"Structural brain network reorganization and social cognition related to adverse perinatal condition from infancy to early adolescence","volume":"10","author":"Mu\u00f1oz-Moreno","year":"2016","journal-title":"Front Neurosci."},{"key":"2021122209575316300_CIT0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.01.043","article-title":"Epigenetic modifications in the nervous system and their impact upon cognitive impairments","volume":"80","author":"Rudenko","year":"2014","journal-title":"Neuropharmacology."},{"key":"2021122209575316300_CIT0046","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.conb.2019.04.012","article-title":"New subtypes of allele-specific epigenetic effects: implications for brain development, function and disease","volume":"59","author":"Kravitz","year":"2019","journal-title":"Curr Opin Neurobiol."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgz151\/30326286\/dgz151.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/4\/e1478\/41860154\/jcem_105_4_e1478.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/4\/e1478\/41860154\/jcem_105_4_e1478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T23:39:38Z","timestamp":1721950778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/4\/e1478\/5609177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,10,29]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgz151","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2019,10,29]]}}}