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Clinical Research Centers","award":["M01RR00069"],"award-info":[{"award-number":["M01RR00069"]}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23AR075099"],"award-info":[{"award-number":["K23AR075099"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Fracture risk in people with type 1 diabetes (T1D) is higher than their peers without diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare bone mineral density (BMD) across the lifespan in individuals with T1D and age- and sex-matched healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Subjects (5\u201371 years) with T1D and matched controls from ongoing research studies at Barbara Davis Center for Diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or other participants<\/jats:title>\n                  <jats:p>Participants with lumbar spine BMD by dual X-ray absorptiometry (DXA) were divided into 2 groups: children \u226420 years and adults &amp;gt;20 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>None.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Comparison of BMD by diabetes status across age groups and sex using a linear least squares model adjusted for age and body mass index (body mass index (BMI) for adults; and BMI z-score in children).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lumbar spine BMD from 194 patients with T1D and 156 controls were analyzed. There was no difference in age- and BMI-adjusted lumbar spine BMD between patients with T1D and controls: among male children (least squares mean \u00b1 standard error of the mean [LSM \u00b1 SEM]; 0.80 \u00b1 0.01 vs 0.80 \u00b1 0.02 g\/cm2, P = .98) or adults (1.01 \u00b1 0.03 vs 1.01 \u00b1 0.03 g\/cm2, P = .95), and female children (0.78 \u00b1 0.02 vs 0.81 \u00b1 0.02 g\/cm2, P = .23) or adults (0.98 \u00b1 0.02 vs 1.01 \u00b1 0.02 g\/cm2, P = .19). Lumbar spine (0.98 \u00b1 0.02 vs 1.04 \u00b1 0.02 g\/cm2, P = .05), femoral neck (0.71 \u00b1 0.02 vs 0.79 \u00b1 0.02 g\/cm2, P = .003), and total hip (0.84 \u00b1 0.02 vs 0.91 \u00b1 0.02, P = .005) BMD was lower among postmenopausal women with T1D than postmenopausal women without diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Across age groups, lumbar spine BMD was similar in patients with T1D compared with age- and sex-matched participants without diabetes, except postmenopausal females with T1D had lower lumbar spine, femoral neck, and total hip BMD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgz153","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T04:59:38Z","timestamp":1572670778000},"page":"746-753","source":"Crossref","is-referenced-by-count":33,"title":["Bone Mineral Density across the Lifespan in Patients 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