{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:05:12Z","timestamp":1791929112530,"version":"4.3.4"},"reference-count":32,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T00:00:00Z","timestamp":1572652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Interdisciplinary Clinical Research Project of Peking University First Hospital","award":["2017CR27"],"award-info":[{"award-number":["2017CR27"]}]},{"name":"Thyroid Research Program of Young and Middle-aged Physicians","award":["2017N14"],"award-info":[{"award-number":["2017N14"]}]},{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Developments","doi-asserted-by":"crossref","award":["2018-4-4077"],"award-info":[{"award-number":["2018-4-4077"]}],"id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The impact of mild TSH elevation (2.5\u20134.08 mIU\/L) on pregnancy outcomes is unclear. The treatment strategy for mild TSH elevation is dependent on thyroid peroxidase antibody (TPOAb) status according to the guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effects of mild thyroid dysfunction combined with TPOAb status in the first trimester on pregnancy outcomes and the impact of levothyroxine (L-T4) treatment on pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The study retrospectively evaluated 3562 pregnant women. A total of 3296 untreated women were divided into 4 subgroups: group A: 4.08 &amp;lt; TSH &amp;lt;10 mIU\/L, TPOAb+\/-; group B: 2.5 &amp;lt; TSH \u2264 4.08 mIU\/L, TPOAb+; group C: 2.5 &amp;lt; TSH \u2264 4.08 mIU\/L, TPOAb\u2013; and group D: 0.23 \u2264 TSH \u2264 2.5 mIU\/L, TPOAb+\/-. The other 266 women with L-T4 treatment were divided into TSH 4.08 to 10 mIU\/L and 2.5 to 4.08 mIU\/L subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was conducted at Peking University First Hospital in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>A total of 3562 pregnant women were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The incidence of pregnancy outcomes in the untreated subgroups (groups A-D) and treated subgroups were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Miscarriage and maternal composite outcome risks were 3.53 (1.85\u20136.75) and 2.19 (1.26\u20133.81) times greater in group A; 1.58 (1.17\u20132.13) and 1.27 (1.04\u20131.54) times greater in group C than in group D. L-T4 improved the miscarriage risk in the TSH 4.08 to 10 and 2.5 to 4.08 mIU\/L groups but doubled the risk of gestational diabetes mellitus in the TSH 2.5 to 4.08 mIU\/L treated group compared with the untreated group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TSH 2.5 to 4.08 mIU\/L combined with TPOAb\u2013 during early pregnancy was associated with miscarriages and maternal composite outcomes. The advantages and disadvantages of L-T4 administration in TSH 2.5 to 4.08 mIU\/L pregnant women remain uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgz167","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T19:16:10Z","timestamp":1572722170000},"page":"e368-e380","source":"Crossref","is-referenced-by-count":32,"title":["The Impact of Thyroid Function and TPOAb in the First Trimester on Pregnancy Outcomes: A Retrospective Study in Peking"],"prefix":"10.1210","volume":"105","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, 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