{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:46:52Z","timestamp":1784126812333,"version":"3.55.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Rays of Hope Center for Breast Cancer Research"},{"name":"Springfield"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Insulin resistance is a risk factor for breast cancer recurrence. How exercise training changes fasting and postglucose insulin resistance in breast cancer survivors is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate exercise-induced changes in postglucose ingestion insulin concentrations, insulin resistance, and their associations with cancer-relevant biomarkers in breast cancer survivors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>The University of Massachusetts Kinesiology Department.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>15 postmenopausal breast cancer survivors not meeting the physical activity guidelines (150 min\/week of exercise).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>A supervised 12-week aerobic exercise program (60 min\/day, 3\u20134 days\/week).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Postglucose ingestion insulin was determined by peak insulin and area under the insulin curve (iAUC) during a 5-sample oral glucose tolerance test. Insulin sensitivity was estimated from the Matsuda composite insulin sensitivity index (C-ISI). Changes in fitness and body composition were determined from submaximal VO2peak and dual energy X-ray absorptiometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants averaged 156.8 \u00b1 16.6 min\/week of supervised exercise. Estimated VO2peak significantly increased (+2.8 \u00b1 1.4 mL\/kg\/min, P &amp;lt; .05) and body weight significantly decreased (\u20131.1 \u00b1 0.8 kg, P &amp;lt; .05) following the intervention. There were no differences in fasting insulin, iAUC, C-ISI, or peak insulin following the intervention. Insulin was only significantly lower 120 min following glucose consumption (68.8 \u00b1 34.5 vs 56.2 \u00b1 31.9 uU\/mL, P &amp;lt; .05), and there was a significant interaction with past\/present aromatase inhibitor (AI) use for peak insulin (\u201311.99 non-AI vs +13.91 AI uU\/mL) and iAUC (-24.03 non-AI vs +32.73 AI uU\/mL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Exercise training had limited overall benefits on insulin concentrations following glucose ingestion in breast cancer survivors but was strongly influenced by AI use.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgz213","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T07:50:49Z","timestamp":1574236249000},"page":"e1958-e1966","source":"Crossref","is-referenced-by-count":9,"title":["Metrics of Diabetes Risk Are Only Minimally Improved by Exercise Training in Postmenopausal Breast Cancer Survivors"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-174X","authenticated-orcid":false,"given":"Richard","family":"Viskochil","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of Massachusetts, Amherst, MA, US"},{"name":"Huntsman Cancer Institute, Salt Lake City, UT, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Blankenship","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Massachusetts, Amherst, MA, US"},{"name":"Anschutz Medical Center, Denver CO, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Makari-Judson","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Baystate Medical Center, Springfield, MA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Staudenmayer","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patty S","family":"Freedson","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Massachusetts, Amherst, MA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E","family":"Hankinson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst MA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Massachusetts, Amherst, MA, US"},{"name":"Department of Health and Exercise Science, Colorado State University, Ft. 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